ilvB:Gene Product(s): Difference between revisions
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Revision as of 18:23, 5 October 2009
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| Quickview | Gene | Gene Product(s) | Expression | Evolution | On One Page |
| Nomenclature | Function | Interactions | Localization | Sequence | Domains | Structure | Resources | Accessions | Links | References | Suggestions |
Nomenclature
See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.
| Standard name |
IlvB |
|---|---|
| Synonyms |
acetolactate synthase I, large subunit[1], B3671[2][1], IlvB[2][1] |
| Product description |
Component of acetohydroxybutanoate synthase I[2] Acetohydroxy acid synthase I (AHAS-I); acetolactate synthase I (ALS-I); valine sensitive; large subunit[4] |
| EC number (for enzymes) | |
| edit table |
Notes
Function
Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.
| Qualifier | GO ID | GO term name | Reference(s) | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0003984 |
acetolactate synthase activity |
IDA: Inferred from Direct Assay |
F |
Seeded from EcoCyc 12.5 [6] |
complete | |||
| GO:0004802 |
transketolase activity |
IDA: Inferred from Direct Assay |
F |
Seeded from EcoCyc [8] |
complete | |||
| GO:0005948 |
acetolactate synthase complex |
IDA: Inferred from Direct Assay |
C |
Seeded from EcoCyc [8] |
complete | |||
| GO:0009097 |
isoleucine biosynthetic process |
IDA: Inferred from Direct Assay |
P |
Seeded from EcoCyc [8] |
complete | |||
| GO:0009099 |
valine biosynthetic process |
IDA: Inferred from Direct Assay |
P |
Seeded from EcoCyc [8] |
complete | |||
| GO:0000287 |
magnesium ion binding |
IEA: Inferred from Electronic Annotation |
InterPro:IPR000399 |
F |
Seeded from EcoCyc [8] |
complete | ||
| GO:0003984 |
acetolactate synthase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc 12.5 [6] |
complete | |||
| GO:0030976 |
thiamin pyrophosphate binding |
GO_REF:0000002 |
IEA: Inferred from Electronic Annotation |
InterPro:IPR000399 |
F |
Seeded from EcoCyc [8] |
complete | |
| GO:0046872 |
metal ion binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc [8] |
complete | |||
| GO:0050660 |
FAD binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc [8] |
complete | |||
| GO:0005737 |
cytoplasm |
C |
Seeded from Riley et al 2006 [1]. |
required fields missing | ||||
| GO:0003824 |
catalytic activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc [8] |
complete | |||
| GO:0008652 |
amino acid biosynthetic process |
IEA: Inferred from Electronic Annotation |
P |
Seeded from EcoCyc [8] |
complete | |||
| GO:0009082 |
branched chain family amino acid biosynthetic process |
IEA: Inferred from Electronic Annotation |
P |
Seeded from EcoCyc [8] |
complete | |||
| GO:0016740 |
transferase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc [8] |
complete | |||
| edit table |
Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.
| Partner Type | Partner | Notes | References | Evidence |
|---|---|---|---|---|
|
Protein |
Subunits of acetohydroxybutanoate synthase I |
could be indirect |
||
|
Protein |
aceE |
Experiment(s):EBI-880536, EBI-886364 | ||
|
Protein |
lpdA |
Experiment(s):EBI-880536, EBI-886364 | ||
|
Protein |
fumA |
Experiment(s):EBI-886364 | ||
|
Protein |
rplL |
Experiment(s):EBI-886364 | ||
|
Protein |
rplM |
Experiment(s):EBI-886364 | ||
|
Protein |
rpsB |
Experiment(s):EBI-886364 | ||
|
Protein |
lpxK |
Experiment(s):EBI-886364 | ||
| edit table |
Notes
Localization
See Help:Product_localization for how to add or edit information in this section of EcoliWiki.
| Compartment | Description | Evidence | Notes |
|---|---|---|---|
| edit table |
Notes
Structure and Physical Properties
Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.
| Sequence |
MASSGTTSTR KRFTGAEFIV HFLEQQGIKI VTGIPGGSIL PVYDALSQST QIRHILARHE QGAGFIAQGM ARTDGKPAVC MACSGPGATN LVTAIADARL DSIPLICITG QVPASMIGTD AFQEVDTYGI SIPITKHNYL VRHIEELPQV MSDAFRIAQS GRPGPVWIDI PKDVQTAVFE IETQPAMAEK AAAPAFSEES IRDAAAMINA AKRPVLYLGG GVINAPARVR ELAEKAQLPT TMTLMALGML PKAHPLSLGM LGMHGVRSTN YILQEADLLI VLGARFDDRA IGKTEQFCPN AKIIHVDIDR AELGKIKQPH VAIQADVDDV LAQLIPLVEA QPRAEWHQLV ADLQREFPCP IPKACDPLSH YGLINAVAAC VDDNAIITTD VGQHQMWTAQ AYPLNRPRQW LTSGGLGTMG FGLPAAIGAA LANPDRKVLC FSGDGSLMMN IQEMATASEN QLDVKIILMN NEALGLVHQQ QSLFYEQGVF AATYPGKINF MQIAAGFGLE TCDLNNEADP QASLQEIINR PGPALIHVRI DAEEKVYPMV PPGAANTEMV GE |
|---|---|
| Length |
562 |
| Mol. Wt |
60.441 kDa |
| pI |
5.3 (calculated) |
| Extinction coefficient |
36,900 - 38,025 (calc based on 10 Y, 4 W, and 9 C residues) |
| edit table |
Domains/Motifs/Modification Sites
|
See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.
|
<motif_map/> |
|
Structure
|
Structure figures
Notes
Gene Product Resources
See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.
| Resource type | Source | Notes/Reference |
|---|---|---|
| edit table |
Notes
Accessions in Other Databases
See Help:Gene_accessions for help with entering information into the Gene Accessions table.
| Database | Accession | Notes |
|---|---|---|
|
| ||
| edit table |
Notes
Links
| Name | URL | Comments |
|---|---|---|
| edit table |
References
See Help:References for how to manage references in EcoliWiki.
- ↑ 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
- ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
- ↑ 5.0 5.1 Vinogradov, V et al. (2006) Acetohydroxyacid synthase isozyme I from Escherichia coli has unique catalytic and regulatory properties. Biochim Biophys Acta 1760 356-63 PubMed
- ↑ 6.0 6.1 EcoCyc (release 12.5; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ 7.0 7.1 Grimminger, H & Umbarger, HE (1979) Acetohydroxy acid synthase I of Escherichia coli: purification and properties. J Bacteriol 137 846-53 PubMed
- ↑ 8.00 8.01 8.02 8.03 8.04 8.05 8.06 8.07 8.08 8.09 8.10 8.11 EcoCyc (release 13.0; 2009) Keseler, IM et al. (2009) Nucleic Acids Res. 37(Database issue):D464-70
- ↑ Eoyang, L & Silverman, PM (1984) Purification and subunit composition of acetohydroxyacid synthase I from Escherichia coli K-12. J Bacteriol 157 184-9 PubMed
- ↑ 10.0 10.1 10.2 10.3 10.4 10.5 10.6 Butland, G et al. (2005) Interaction network containing conserved and essential protein complexes in Escherichia coli. Nature 433 531-7 PubMed
Categories
- GO:0003984 ! acetolactate synthase activity
- GO:0004802 ! transketolase activity
- GO:0005948 ! acetolactate synthase complex
- GO:0009097 ! isoleucine biosynthetic process
- GO:0009099 ! valine biosynthetic process
- GO:0000287 ! magnesium ion binding
- GO:0030976 ! thiamine pyrophosphate binding
- GO:0046872 ! metal ion binding
- GO:0050660 ! flavin adenine dinucleotide binding
- GO:0005737 ! cytoplasm
- GO:0003824 ! catalytic activity
- GO:0008652 ! cellular amino acid biosynthetic process
- GO:0009082 ! branched-chain amino acid biosynthetic process
- GO:0016740 ! transferase activity
- Proteins
- Complex:acetohydroxybutanoate synthase I