clcA:Gene Product(s): Difference between revisions

Standard name	ClcA
Synonyms	chloride channel, voltage-gated^[1], B0155^[2]^[1], EriC^[2]^[1], ClcA^[2]^[1], YadQ^[2]^[1]
Product description	EriC chloride ion ClC channel^[2]^[3] Voltage-gated ClC-type chloride channel; involved in the extreme acid response^[4]
EC number (for enzymes)
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Notes

Function

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Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier	GO ID	GO term name	Reference(s)	Evidence Code	with/from	Aspect	Notes	Status
	GO:0031404	chloride ion binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0868	F	Seeded from EcoCyc ^[5]	complete
	GO:0016021	integral to membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0812	C	Seeded from EcoCyc ^[5]	complete
	GO:0016020	membrane	GO_REF:0000002 GO_REF:0000004 GO_REF:0000004	IEA: Inferred from Electronic Annotation	InterPro:IPR001807 SP_KW:KW-0397 SP_KW:KW-0472	C	Seeded from EcoCyc 12.5 ^[6]	complete
	GO:0015297	antiporter activity	GO_REF:0000004 GO_REF:0000020	IEA: Inferred from Electronic Annotation	SP_KW:KW-0050 HAMAP:MF_01128	F	Seeded from EcoCyc 12.5 ^[6]	complete
	GO:0006950	response to stress	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0346	P	Seeded from EcoCyc ^[5]	complete
	GO:0006821	chloride transport	GO_REF:0000002 GO_REF:0000020	IEA: Inferred from Electronic Annotation	InterPro:IPR001807 HAMAP:MF_01128	P	Seeded from EcoCyc 12.5 ^[6]	complete
	GO:0006811	ion transport	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0406	P	Seeded from EcoCyc ^[5]	complete
	GO:0006810	transport	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0813	P	Seeded from EcoCyc ^[5]	complete
	GO:0005247	voltage-gated chloride channel activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001807	F	Seeded from EcoCyc ^[5]	complete
	GO:0005216	ion channel activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR014743	F	Seeded from EcoCyc ^[5]	complete
	GO:0005886	plasma membrane	GO_REF:0000020 GO_REF:0000004 GO_REF:0000004 GO_REF:0000023	IEA: Inferred from Electronic Annotation	HAMAP:MF_01128 SP_KW:KW-0997 SP_KW:KW-1003 SP_SL:SL-0037	C	Seeded from EcoCyc ^[5]	complete
	GO:0005216	ion channel activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR014743	F	Seeded from EcoCyc	complete
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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type	Partner	Notes	References	Evidence
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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment	Description	Evidence	Notes
plasma membrane	C-terminus localized in the cytoplasm with 10 predicted transmembrane domains	Daley et al. (2005) ^[7]
plasma membrane			From EcoCyc^[3]
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Notes

Structure and Physical Properties

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Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Sequence	at EcoCyc MKTDTPSLET PQAARLRRRQ LIRQLLERDK TPLAILFMAA VVGTLVGLAA VAFDKGVAWL QNQRMGALVH TADNYPLLLT VAFLCSAVLA MFGYFLVRKY APEAGGSGIP EIEGALEDQR PVRWWRVLPV KFFGGLGTLG GGMVLGREGP TVQIGGNIGR MVLDIFRLKG DEARHTLLAT GAAAGLAAAF NAPLAGILFI IEEMRPQFRY TLISIKAVFI GVIMSTIMYR IFNHEVALID VGKLSDAPLN TLWLYLILGI IFGIFGPIFN KWVLGMQDLL HRVHGGNITK WVLMGGAIGG LCGLLGFVAP ATSGGGFNLI PIATAGNFSM GMLVFIFVAR VITTLLCFSS GAPGGIFAPM LALGTVLGTA FGMVAVELFP QYHLEAGTFA IAGMGALLAA SIRAPLTGII LVLEMTDNYQ LILPMIITGL GATLLAQFTG GKPLYSAILA RTLAKQEAEQ LARSKAASAS ENT
Length	473
Mol. Wt	50.35 kDa (calc) ^[2]
pI
Extinction coefficient	46410 - 46785 (calc based on 9 Y, 6 W, and 3 C residues)
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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type	Residues	Description	Notes
Domain	210 - 232	Predicted membrane-spanning helix.	TMD predicted by TMHMM^[8]
Domain	252 - 274	Predicted membrane-spanning helix.	TMD predicted by TMHMM^[8]
Domain	287 - 309	Predicted membrane-spanning helix.	TMD predicted by TMHMM^[8]
Domain	319 - 341	Predicted membrane-spanning helix.	TMD predicted by TMHMM^[8]
Domain	354 - 376	Predicted membrane-spanning helix.	TMD predicted by TMHMM^[8]
Domain	391 - 413	Predicted membrane-spanning helix.	TMD predicted by TMHMM^[8]
Domain	418 - 440	Predicted membrane-spanning helix.	TMD predicted by TMHMM^[8]
Domain	31 - 53	Predicted membrane-spanning helix.	TMD predicted by TMHMM^[8]
Domain	75 - 97	Predicted membrane-spanning helix.	TMD predicted by TMHMM^[8]
Domain	124 - 146	Predicted membrane-spanning helix.	TMD predicted by TMHMM^[8]
Domain	179 - 201	Predicted membrane-spanning helix.	TMD predicted by TMHMM^[8]
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<motif_map/>

Click the image to view raw output from TMHMM.

Structure See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

Models

View models at:

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type	Source	Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
EcoCyc (EcoliWiki Page)	EcoCyc:YADQ-MONOMER
UniProt (EcoliWiki Page)	UniProt:P37019
PFAM (EcoliWiki Page)	PFAM:PF00654
RefSeq (EcoliWiki Page)	RefSeq:NP_414697
ModBase (EcoliWiki Page)	ModBase:P37019
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Notes

Links

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Name	URL	Comments
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References

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↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^3.0 ^3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 EcoCyc (release 13.0; 2009) Keseler, IM et al. (2009) Nucleic Acids Res. 37(Database issue):D464-70
↑ ^6.0 ^6.1 ^6.2 EcoCyc (release 12.5; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ Daley, DO et al. (2005) Global topology analysis of the Escherichia coli inner membrane proteome. Science 308 1321-3 PubMed
↑ ^8.00 ^8.01 ^8.02 ^8.03 ^8.04 ^8.05 ^8.06 ^8.07 ^8.08 ^8.09 ^8.10 Krogh, A et al. (2001) Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes. J. Mol. Biol. 305 567-80 PubMed

clcA:Gene Product(s): Difference between revisions

Revision as of 00:01, 22 May 2009

Nomenclature

Notes

Function

Notes

Localization

Notes

Structure and Physical Properties

Notes

Gene Product Resources

Notes

Accessions in Other Databases

Notes

Links

References

Categories

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 Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
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+complete
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+GO:0005216
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+ion channel activity
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+GO_REF:0000002
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+IEA: Inferred from Electronic Annotation
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+InterPro:IPR014743
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+F
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+Seeded from EcoCyc
 |
 complete

clcA:Gene Product(s): Difference between revisions

Revision as of 00:01, 22 May 2009

Nomenclature

Notes

Function

Notes

Localization

Notes

Structure and Physical Properties

Notes

Gene Product Resources

Notes

Accessions in Other Databases

Notes

Links

References

Categories

Navigation menu

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