cls:Gene Product(s): Difference between revisions

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C
C
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Seeded from EcoCyc
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complete
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GO:0008152
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metabolic process
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GO_REF:0000002
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IEA: Inferred from Electronic Annotation
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InterPro:IPR001736
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P
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Seeded from EcoCyc
Seeded from EcoCyc
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GO:0008152
GO:0008654
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metabolic process
phospholipid biosynthetic process
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GO_REF:0000002
GO_REF:0000020<br />GO_REF:0000004
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IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
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InterPro:IPR001736
HAMAP:MF_00190<br />SP_KW:KW-0594
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P
P

Revision as of 23:03, 21 May 2009

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

Cls

Synonyms

cardiolipin synthase 1[1], B1249[2][1], YciJ[2][1], Nov[2][1], Cls[2][1]

Product description

Cardiolipin synthase; mutants dihydroxybutylphosphonate resistant; novobiocin sensitivity[3]

EC number (for enzymes) 
2.7.8.-[1]
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Notes

Function

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Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference(s) Evidence Code with/from Aspect Notes Status
GO:0016780

phosphotransferase activity, for other substituted phosphate groups

GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00190

F

Seeded from EcoCyc [4]

complete

GO:0016021

integral to membrane

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0812

C

Seeded from EcoCyc [4]

complete

GO:0016740

transferase activity

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0808

F

Seeded from EcoCyc [4]

complete

GO:0016020

membrane

GO_REF:0000004
GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0397
SP_KW:KW-0472

C

Seeded from EcoCyc 12.5 [5]

complete

GO:0003824

catalytic activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001736

F

Seeded from EcoCyc [4]

complete

GO:0008152

metabolic process

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001736

P

Seeded from EcoCyc [4]

complete

GO:0008808

cardiolipin synthase activity

PMID:353047[6]

IMP: Inferred from Mutant Phenotype

F

Seeded from EcoCyc [4]

complete

GO:0005886

plasma membrane

GO_REF:0000020
GO_REF:0000004
GO_REF:0000004
GO_REF:0000023

IEA: Inferred from Electronic Annotation

HAMAP:MF_00190
SP_KW:KW-0997
SP_KW:KW-1003
SP_SL:SL-0037

C

Seeded from EcoCyc [4]

complete

GO:0003824

catalytic activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001736

F

Seeded from EcoCyc

complete

GO:0005886

plasma membrane

GO_REF:0000020
GO_REF:0000004
GO_REF:0000004
GO_REF:0000023

IEA: Inferred from Electronic Annotation

HAMAP:MF_00190
SP_KW:KW-0997
SP_KW:KW-1003
SP_SL:SL-0037

C

Seeded from EcoCyc

complete

GO:0008152

metabolic process

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001736

P

Seeded from EcoCyc

complete

GO:0042493

response to drug

P

Seeded from EcoCyc 11.1[7].

required fields missing

GO:0008808

cardiolipin synthase activity

PMID:353047[6]

IMP: Inferred from Mutant Phenotype

F

complete

GO:0008654

phospholipid biosynthetic process

GO_REF:0000020
GO_REF:0000004

IEA: Inferred from Electronic Annotation

HAMAP:MF_00190
SP_KW:KW-0594

P

Seeded from EcoCyc

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence
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Notes

Required for synthesis of cardiolipin.

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Notes

plasma membrane

From EcoCyc[7]

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Notes

Structure and Physical Properties

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Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Sequence

at EcoCyc 

MTTVYTLVSW LAILGYWLLI AGVTLRILMK RRAVPSAMAW LLIIYILPLV GIIAYLAVGE
LHLGKRRAER ARAMWPSTAK WLNDLKACKH IFAEENSSVA APLFKLCERR QGIAGVKGNQ
LQLMTESDDV MQALIRDIQL ARHNIEMVFY IWQPGGMADQ VAESLMAAAR RGIHCRLMLD
SAGSVAFFRS PWPELMRNAG IEVVEALKVN LMRVFLRRMD LRQHRKMIMI DNYIAYTGSM
NMVDPRYFKQ DAGVGQWIDL MARMEGPIAT AMGIIYSCDW EIETGKRILP PPPDVNIMPF
EQASGHTIHT IASGPGFPED LIHQALLTAA YSAREYLIMT TPYFVPSDDL LHAICTAAQR
GVDVSIILPR KNDSMLVGWA SRAFFTELLA AGVKIYQFEG GLLHTKSVLV DGELSLVGTV
NLDMRSLWLN FEITLAIDDK GFGADLAAVQ DDYISRSRLL DARLWLKRPL WQRVAERLFY
FFSPLL
Length

486

Mol. Wt

54.82 kDa (calc) [2]

pI
Extinction coefficient

93850 - 94475 (calc based on 15 Y, 13 W, and 5 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes

Domain

219 - 246

PLD phosphodiesterase 1

UniProt:P0A6H8

Domain

399 - 426

PLD phosphodiesterase 2

UniProt:P0A6H8

Domain

10 - 29

Predicted membrane-spanning helix.

TMD predicted by TMHMM[8]

Domain

36 - 58

Predicted membrane-spanning helix.

TMD predicted by TMHMM[8]

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<motif_map/>

tmhmm.php?gene=cls&show=pic&.jpg
Click the image to view raw output from TMHMM.

Structure See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure>cls 562</beststructure>

Models

View models at:

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

EcoCyc (EcoliWiki Page)

EcoCyc:CARDIOLIPSYN-MONOMER

UniProt (EcoliWiki Page)

UniProt:P0A6H8

PFAM (EcoliWiki Page)

PFAM:PF00614

RefSeq (EcoliWiki Page)

RefSeq:NP_415765

ModBase (EcoliWiki Page)

ModBase:P0A6H8


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Notes

Links

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Name URL Comments
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References

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  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  4. ↑ 4.0 4.1 4.2 4.3 4.4 4.5 4.6 EcoCyc (release 13.0; 2009) Keseler, IM et al. (2009) Nucleic Acids Res. 37(Database issue):D464-70
  5. ↑ EcoCyc (release 12.5; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  6. ↑ 6.0 6.1 Pluschke, G et al. (1978) Function of phospholipids in Escherichia coli. Characterization of a mutant deficient in cardiolipin synthesis. J. Biol. Chem. 253 5048-55 PubMed
  7. ↑ 7.0 7.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  8. ↑ 8.0 8.1 Krogh, A et al. (2001) Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes. J. Mol. Biol. 305 567-80 PubMed


Categories

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