arnT:Gene Product(s): Difference between revisions

Standard name	ArnT
Synonyms	4-amino-4-deoxy-L-arabinose transferase^[1], B2257^[2]^[1], YfbI^[2]^[1], ArnT^[2]^[1], PmrK^[2]^[1], Orf5^[2]^[1]
Product description	4-amino-4-deoxy-L-arabinose (L-Ara4N) transferase^[2]^[3] 4-amino-4-deoxy-L-arabinose(Ara4N):Lipid A transferase; modifies lipid A phosphates with aminoarabinose and confers resistance to polymyxin B and cationic antimicrobial peptides; glycolipid donor is undecaprenyl phosphate-alpha-L-Ara4N^[4]
EC number (for enzymes)
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Notes

Function

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Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier	GO ID	GO term name	Reference(s)	Evidence Code	with/from	Aspect	Notes	Status
	GO:0016757	transferase activity, transferring glycosyl groups	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0328	F	Seeded from EcoCyc ^[5]	complete
	GO:0016740	transferase activity	GO_REF:0000004 GO_REF:0000020	IEA: Inferred from Electronic Annotation	SP_KW:KW-0808 HAMAP:MF_01165	F	Seeded from EcoCyc 12.5 ^[6]	complete
	GO:0016021	integral to membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0812	C	Seeded from EcoCyc ^[5]	complete
	GO:0016020	membrane	GO_REF:0000002 GO_REF:0000004 GO_REF:0000004	IEA: Inferred from Electronic Annotation	InterPro:IPR003342 SP_KW:KW-0397 SP_KW:KW-0472	C	Seeded from EcoCyc 12.5 ^[6]	complete
	GO:0009245	lipid A biosynthetic process	GO_REF:0000004 GO_REF:0000020	IEA: Inferred from Electronic Annotation	SP_KW:KW-0441 HAMAP:MF_01165	P	Seeded from EcoCyc 12.5 ^[6]	complete
	GO:0009103	lipopolysaccharide biosynthetic process	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0448	P	Seeded from EcoCyc 12.5 ^[6]	complete
	GO:0008610	lipid biosynthetic process	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0444	P	Seeded from EcoCyc ^[5]	complete
	GO:0006493	protein amino acid O-linked glycosylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR003342	P	Seeded from EcoCyc ^[5]	complete
	GO:0000030	mannosyltransferase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR003342	F	Seeded from EcoCyc ^[5]	complete
	GO:0009103	lipopolysaccharide biosynthetic process	PMID:11535605^[7]	IMP: Inferred from Mutant Phenotype		P	Seeded from EcoCyc 12.5 ^[6]	complete
	GO:0010041	response to iron(III) ion	PMID:12139617^[8]	IGI: Inferred from Genetic Interaction	UniProtKB:P30843	P	Seeded from EcoCyc 12.5 ^[6]	complete
	GO:0010041	response to iron(III) ion	PMID:15322361^[9]	IEP: Inferred from Expression Pattern		P	Seeded from EcoCyc 12.5 ^[6]	complete
	GO:0016763	transferase activity, transferring pentosyl groups	PMID:17928292^[10]	IMP: Inferred from Mutant Phenotype		F	Seeded from EcoCyc ^[5]	complete
	GO:0006950	response to stress				P	Seeded from EcoCyc 11.1^[3].	required fields missing
	GO:0005886	plasma membrane	GO_REF:0000020 GO_REF:0000004 GO_REF:0000004 GO_REF:0000023	IEA: Inferred from Electronic Annotation	HAMAP:MF_01165 SP_KW:KW-0997 SP_KW:KW-1003 SP_SL:SL-0037	C	Seeded from EcoCyc ^[5]	complete
	GO:0000030	mannosyltransferase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR003342	F	Seeded from EcoCyc	complete
	GO:0005886	plasma membrane	GO_REF:0000020 GO_REF:0000004 GO_REF:0000004 GO_REF:0000023	IEA: Inferred from Electronic Annotation	HAMAP:MF_01165 SP_KW:KW-0997 SP_KW:KW-1003 SP_SL:SL-0037	C	Seeded from EcoCyc	complete
	GO:0006493	protein amino acid O-linked glycosylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR003342	P	Seeded from EcoCyc	complete
	GO:0008610	lipid biosynthetic process	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0444	P	Seeded from EcoCyc	complete
	GO:0009103	lipopolysaccharide biosynthetic process	GO_REF:0000004 PMID:11535605^[7]	IMP: Inferred from Mutant Phenotype	SP_KW:KW-0448	P	Seeded from EcoCyc	complete
	GO:0009245	lipid A biosynthetic process	GO_REF:0000020 GO_REF:0000004	IEA: Inferred from Electronic Annotation	HAMAP:MF_01165 SP_KW:KW-0441	P	Seeded from EcoCyc	complete
	GO:0010041	response to iron(III) ion	PMID:12139617^[8] PMID:15322361^[9]	IEP: Inferred from Expression Pattern	UniProtKB:P30843	P	Seeded from EcoCyc	complete
	GO:0016020	membrane	GO_REF:0000002 GO_REF:0000004	IEA: Inferred from Electronic Annotation	InterPro:IPR003342 SP_KW:KW-0472	C	Seeded from EcoCyc	complete
	GO:0016021	integral to membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0812	C	Seeded from EcoCyc	complete
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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type	Partner	Notes	References	Evidence
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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment	Description	Evidence	Notes
plasma membrane			From EcoCyc^[3]
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Notes

Structure and Physical Properties

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Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Sequence	at EcoCyc MKSVRYLIGL FAFIACYYLL PISTRLLWQP DETRYAEISR EMLASGDWIV PHLLGLRYFE KPIAGYWINS IGQWLFGANN FGVRAGVIFA TLLTAALVTW FTLRLWRDKR LALLATVIYL SLFIVYAIGT YAVLDPFIAF WLVAGMCSFW LAMQAQTWKG KSAGFLLLGI TCGMGVMTKG FLALAVPVLS VLPWVATQKR WKDLFIYGWL AVISCVLTVL PWGLAIAQRE PNFWHYFFWV EHIQRFALDD AQHRAPFWYY VPVIIAGSLP WLGLLPGALY TGWKNRKHSA TVYLLSWTIM PLLFFSVAKG KLPTYILSCF ASLAMLMAHY ALLAAKNNPL ALRINGWINI AFGVTGIIAT FVVSPWGPMN TPVWQTFESY KVFCAWSIFS LWAFFGWYTL TNVEKTWPFA ALCPLGLALL VGFSIPDRVM EGKHPQFFVE MTQESLQPSR YILTDSVGVA AGLAWSLQRD DIIMYRQTGE LKYGLNYPDA KGRFVSGDEF ANWLNQHRQE GIITLVLSVD RDEDINSLAI PPADAIDRQE RLVLIQYRPK
Length	550
Mol. Wt	62.54 kDa (calc) ^[2]
pI
Extinction coefficient	189760 - 190635 (calc based on 24 Y, 28 W, and 7 C residues)
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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type	Residues	Description	Notes
Domain	7 - 29	Predicted membrane-spanning helix.	TMD predicted by TMHMM^[11]
Domain	82 - 104	Predicted membrane-spanning helix.	TMD predicted by TMHMM^[11]
Domain	111 - 133	Predicted membrane-spanning helix.	TMD predicted by TMHMM^[11]
Domain	137 - 154	Predicted membrane-spanning helix.	TMD predicted by TMHMM^[11]
Domain	167 - 189	Predicted membrane-spanning helix.	TMD predicted by TMHMM^[11]
Domain	204 - 226	Predicted membrane-spanning helix.	TMD predicted by TMHMM^[11]
Domain	257 - 279	Predicted membrane-spanning helix.	TMD predicted by TMHMM^[11]
Domain	289 - 308	Predicted membrane-spanning helix.	TMD predicted by TMHMM^[11]
Domain	315 - 334	Predicted membrane-spanning helix.	TMD predicted by TMHMM^[11]
Domain	344 - 366	Predicted membrane-spanning helix.	TMD predicted by TMHMM^[11]
Domain	379 - 401	Predicted membrane-spanning helix.	TMD predicted by TMHMM^[11]
Domain	406 - 425	Predicted membrane-spanning helix.	TMD predicted by TMHMM^[11]
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<motif_map/>

Click the image to view raw output from TMHMM.

Structure See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

Models

View models at:

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type	Source	Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
EcoCyc (EcoliWiki Page)	EcoCyc:G7170-MONOMER
UniProt (EcoliWiki Page)	UniProt:P76473
PFAM (EcoliWiki Page)	PFAM:PF02366
RefSeq (EcoliWiki Page)	RefSeq:NP_416760
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Notes

Links

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Name	URL	Comments
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References

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↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^3.0 ^3.1 ^3.2 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 EcoCyc (release 13.0; 2009) Keseler, IM et al. (2009) Nucleic Acids Res. 37(Database issue):D464-70
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 EcoCyc (release 12.5; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^7.0 ^7.1 Trent, MS et al. (2001) Accumulation of a polyisoprene-linked amino sugar in polymyxin-resistant Salmonella typhimurium and Escherichia coli: structural characterization and transfer to lipid A in the periplasm. J Biol Chem 276 43132-44 PubMed
↑ ^8.0 ^8.1 Chamnongpol, S et al. (2002) Fe(III)-mediated cellular toxicity. Mol. Microbiol. 45 711-9 PubMed
↑ ^9.0 ^9.1 Hagiwara, D et al. (2004) A Genome-wide view of the Escherichia coli BasS-BasR two-component system implicated in iron-responses. Biosci. Biotechnol. Biochem. 68 1758-67 PubMed
↑ Yan, A et al. (2007) An undecaprenyl phosphate-aminoarabinose flippase required for polymyxin resistance in Escherichia coli. J Biol Chem 282 36077-89 PubMed
↑ ^11.00 ^11.01 ^11.02 ^11.03 ^11.04 ^11.05 ^11.06 ^11.07 ^11.08 ^11.09 ^11.10 ^11.11 Krogh, A et al. (2001) Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes. J. Mol. Biol. 305 567-80 PubMed

arnT:Gene Product(s): Difference between revisions

Revision as of 22:15, 21 May 2009

Nomenclature

Notes

Function

Notes

Localization

Notes

Structure and Physical Properties

Notes

Gene Product Resources

Notes

Accessions in Other Databases

Notes

Links

References

Categories

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 InterPro:IPR003342<br />SP_KW:KW-0472
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+C
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+Seeded from EcoCyc
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+complete
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+GO:0016021
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+integral to membrane
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+GO_REF:0000004
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+IEA: Inferred from Electronic Annotation
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+SP_KW:KW-0812
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 C

arnT:Gene Product(s): Difference between revisions

Revision as of 22:15, 21 May 2009

Nomenclature

Notes

Function

Notes

Localization

Notes

Structure and Physical Properties

Notes

Gene Product Resources

Notes

Accessions in Other Databases

Notes

Links

References

Categories

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