thyA:Quickview: Difference between revisions

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===Notes===
===Notes===
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Thymidylate synthase (TS) catalytic mechanism order: TS + dUMP --> TS x dUMP + (6R)-5,10-CH2-H4folate --> TS x dUMP x (6R)-5,10-CH2H4folate --> TS x dTMP x H2folate --> TS x dTMP --> TS.<ref name='LIB:EcoGene'/>





Revision as of 00:43, 3 March 2009

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
References Suggestions
Gene Name

thyA (synonyms: ECK2823, b2827, JW2795)[1]

Product(s)

ThyA product[1]: thymidylate synthetase product, B2827 product, 5,10-methylenetetrahydrofolate:dUMP C-methyltransferase product

Description

thymidylate synthase[2][3]

Component of thymidylate synthase[2]

Knock-Out Phenotype
Regulation/Expression

transcription unit(s): lgt-thyA[2]

Regulation/Activity


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Notes

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Thymidylate synthase (TS) catalytic mechanism order: TS + dUMP --> TS x dUMP + (6R)-5,10-CH2-H4folate --> TS x dUMP x (6R)-5,10-CH2H4folate --> TS x dTMP x H2folate --> TS x dTMP --> TS.[4]



References

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  1. ↑ 1.0 1.1 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.