clcA:Gene Product(s): Difference between revisions

Standard name	ClcA
Synonyms	chloride channel, voltage-gated^[1], B0155^[2]^[1], EriC^[2]^[1], ClcA^[2]^[1], YadQ^[2]^[1]
Product description	EriC chloride ion ClC channel^[2]^[3]
EC number (for enzymes)
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Notes

Function

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Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier	GO ID	GO term name	Reference(s)	Evidence Code	with/from	Aspect	Notes	Status
	GO:0031404	chloride ion binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0868	F	Seeded from EcoCyc 12.5 ^[4]	complete
	GO:0016021	integral to membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0812	C	Seeded from EcoCyc 12.5 ^[4]	complete
	GO:0016020	membrane	GO_REF:0000002 GO_REF:0000004 GO_REF:0000004	IEA: Inferred from Electronic Annotation	InterPro:IPR001807 SP_KW:KW-0397 SP_KW:KW-0472	C	Seeded from EcoCyc 12.5 ^[4]	complete
	GO:0015297	antiporter activity	GO_REF:0000004 GO_REF:0000020	IEA: Inferred from Electronic Annotation	SP_KW:KW-0050 HAMAP:MF_01128	F	Seeded from EcoCyc 12.5 ^[4]	complete
	GO:0006950	response to stress	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0346	P	Seeded from EcoCyc 12.5 ^[4]	complete
	GO:0006821	chloride transport	GO_REF:0000002 GO_REF:0000020	IEA: Inferred from Electronic Annotation	InterPro:IPR001807 HAMAP:MF_01128	P	Seeded from EcoCyc 12.5 ^[4]	complete
	GO:0006811	ion transport	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0406	P	Seeded from EcoCyc 12.5 ^[4]	complete
	GO:0006810	transport	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0813	P	Seeded from EcoCyc 12.5 ^[4]	complete
	GO:0005247	voltage-gated chloride channel activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001807	F	Seeded from EcoCyc 12.5 ^[4]	complete
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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type	Partner	Notes	References	Evidence
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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment	Description	Evidence	Notes
plasma membrane	C-terminus localized in the cytoplasm with 10 predicted transmembrane domains	Daley et al. (2005) ^[5]
plasma membrane			From EcoCyc^[3]
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Notes

Structure and Physical Properties

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Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Sequence	at EcoCyc MKTDTPSLET PQAARLRRRQ LIRQLLERDK TPLAILFMAA VVGTLVGLAA VAFDKGVAWL QNQRMGALVH TADNYPLLLT VAFLCSAVLA MFGYFLVRKY APEAGGSGIP EIEGALEDQR PVRWWRVLPV KFFGGLGTLG GGMVLGREGP TVQIGGNIGR MVLDIFRLKG DEARHTLLAT GAAAGLAAAF NAPLAGILFI IEEMRPQFRY TLISIKAVFI GVIMSTIMYR IFNHEVALID VGKLSDAPLN TLWLYLILGI IFGIFGPIFN KWVLGMQDLL HRVHGGNITK WVLMGGAIGG LCGLLGFVAP ATSGGGFNLI PIATAGNFSM GMLVFIFVAR VITTLLCFSS GAPGGIFAPM LALGTVLGTA FGMVAVELFP QYHLEAGTFA IAGMGALLAA SIRAPLTGII LVLEMTDNYQ LILPMIITGL GATLLAQFTG GKPLYSAILA RTLAKQEAEQ LARSKAASAS ENT
Mol. Wt	50.35 kDa (calc) ^[2]
pI
Extinction coefficient	46410 - 46785 (calc based on 9 Y, 6 W, and 3 C residues)
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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type	Residues	Description	Notes
Domain	210 - 232	Predicted membrane-spanning helix.	TMD predicted by TMHMM^[6]
Domain	252 - 274	Predicted membrane-spanning helix.	TMD predicted by TMHMM^[6]
Domain	287 - 309	Predicted membrane-spanning helix.	TMD predicted by TMHMM^[6]
Domain	319 - 341	Predicted membrane-spanning helix.	TMD predicted by TMHMM^[6]
Domain	354 - 376	Predicted membrane-spanning helix.	TMD predicted by TMHMM^[6]
Domain	391 - 413	Predicted membrane-spanning helix.	TMD predicted by TMHMM^[6]
Domain	418 - 440	Predicted membrane-spanning helix.	TMD predicted by TMHMM^[6]
Domain	31 - 53	Predicted membrane-spanning helix.	TMD predicted by TMHMM^[6]
Domain	75 - 97	Predicted membrane-spanning helix.	TMD predicted by TMHMM^[6]
Domain	124 - 146	Predicted membrane-spanning helix.	TMD predicted by TMHMM^[6]
Domain	179 - 201	Predicted membrane-spanning helix.	TMD predicted by TMHMM^[6]
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Click the image to view raw output from TMHMM.

Structure See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

Models

View models at:

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type	Source	Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
EcoCyc (EcoliWiki Page)	EcoCyc:YADQ-MONOMER
UniProt (EcoliWiki Page)	UniProt:P37019
PFAM (EcoliWiki Page)	PFAM:PF00654
RefSeq (EcoliWiki Page)	RefSeq:NP_414697
ModBase (EcoliWiki Page)	ModBase:P37019
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Notes

Links

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Name	URL	Comments
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References

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↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^3.0 ^3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 ^4.8 EcoCyc (release 12.5; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ Daley, DO et al. (2005) Global topology analysis of the Escherichia coli inner membrane proteome. Science 308 1321-3 PubMed
↑ ^6.00 ^6.01 ^6.02 ^6.03 ^6.04 ^6.05 ^6.06 ^6.07 ^6.08 ^6.09 ^6.10 Krogh, A et al. (2001) Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes. J. Mol. Biol. 305 567-80 PubMed

clcA:Gene Product(s): Difference between revisions

Revision as of 19:22, 16 February 2009

Nomenclature

Notes

Function

Notes

Localization

Notes

Structure and Physical Properties

Notes

Gene Product Resources

Notes

Accessions in Other Databases

Notes

Links

References

Categories

Navigation menu

@@ Line 81: / Line 81: @@
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-[[Category:GO:0031404_!_chloride_ion_binding]][http://gowiki.tamu.edu/wiki/index.php/Category:GO:0031404_!_chloride_ion_binding GO:0031404]
+GO:0031404
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 chloride ion binding
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-[http://www.geneontology.org/cgi-bin/references.cgi#GO_REF:0000004 GO_REF:0000004]
+GO_REF:0000004
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 IEA: Inferred from Electronic Annotation
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-[http://www.uniprot.org/keywords/KW-0868 SP_KW:KW-0868]
+SP_KW:KW-0868
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 F
@@ Line 100: / Line 100: @@
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-[[Category:GO:0016021_!_integral_to_membrane]][http://gowiki.tamu.edu/wiki/index.php/Category:GO:0016021_!_integral_to_membrane GO:0016021]
+GO:0016021
 |
 integral to membrane
 |
-[http://www.geneontology.org/cgi-bin/references.cgi#GO_REF:0000004 GO_REF:0000004]
+GO_REF:0000004
 |
 IEA: Inferred from Electronic Annotation
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-[http://www.uniprot.org/keywords/KW-0812 SP_KW:KW-0812]
+SP_KW:KW-0812
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 C
@@ Line 119: / Line 119: @@
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-[[Category:GO:0016020_!_membrane]][http://gowiki.tamu.edu/wiki/index.php/Category:GO:0016020_!_membrane GO:0016020]
+GO:0016020
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 membrane
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-[http://www.geneontology.org/cgi-bin/references.cgi#GO_REF:0000002 GO_REF:0000002]<br />[http://www.geneontology.org/cgi-bin/references.cgi#GO_REF:0000004 GO_REF:0000004]<br />[http://www.geneontology.org/cgi-bin/references.cgi#GO_REF:0000004 GO_REF:0000004]
+GO_REF:0000002<br />GO_REF:0000004<br />GO_REF:0000004
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 IEA: Inferred from Electronic Annotation
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-[http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR001807 InterPro:IPR001807]<br />[http://www.uniprot.org/keywords/KW-0397 SP_KW:KW-0397]<br />[http://www.uniprot.org/keywords/KW-0472 SP_KW:KW-0472]
+InterPro:IPR001807<br />SP_KW:KW-0397<br />SP_KW:KW-0472
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 C
@@ Line 138: / Line 138: @@
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-[[Category:GO:0015297_!_antiporter_activity]][http://gowiki.tamu.edu/wiki/index.php/Category:GO:0015297_!_antiporter_activity GO:0015297]
+GO:0015297
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 antiporter activity
 |
-[http://www.geneontology.org/cgi-bin/references.cgi#GO_REF:0000004 GO_REF:0000004]<br />[http://www.geneontology.org/cgi-bin/references.cgi#GO_REF:0000020 GO_REF:0000020]
+GO_REF:0000004<br />GO_REF:0000020
 |
 IEA: Inferred from Electronic Annotation
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-[http://www.uniprot.org/keywords/KW-0050 SP_KW:KW-0050]<br />[http://ca.expasy.org/unirule/MF_01128 HAMAP:MF_01128]
+SP_KW:KW-0050<br />HAMAP:MF_01128
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 F
@@ Line 157: / Line 157: @@
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-[[Category:GO:0006950_!_response_to_stress]][http://gowiki.tamu.edu/wiki/index.php/Category:GO:0006950_!_response_to_stress GO:0006950]
+GO:0006950
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 response to stress
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-[http://www.geneontology.org/cgi-bin/references.cgi#GO_REF:0000004 GO_REF:0000004]
+GO_REF:0000004
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 IEA: Inferred from Electronic Annotation
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-[http://www.uniprot.org/keywords/KW-0346 SP_KW:KW-0346]
+SP_KW:KW-0346
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 P
@@ Line 176: / Line 176: @@
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-[[Category:GO:0006821_!_chloride_transport]][http://gowiki.tamu.edu/wiki/index.php/Category:GO:0006821_!_chloride_transport GO:0006821]
+GO:0006821
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 chloride transport
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-[http://www.geneontology.org/cgi-bin/references.cgi#GO_REF:0000002 GO_REF:0000002]<br />[http://www.geneontology.org/cgi-bin/references.cgi#GO_REF:0000020 GO_REF:0000020]
+GO_REF:0000002<br />GO_REF:0000020
 |
 IEA: Inferred from Electronic Annotation
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-[http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR001807 InterPro:IPR001807]<br />[http://ca.expasy.org/unirule/MF_01128 HAMAP:MF_01128]
+InterPro:IPR001807<br />HAMAP:MF_01128
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 P
@@ Line 195: / Line 195: @@
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-[[Category:GO:0006811_!_ion_transport]][http://gowiki.tamu.edu/wiki/index.php/Category:GO:0006811_!_ion_transport GO:0006811]
+GO:0006811
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 ion transport
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-[http://www.geneontology.org/cgi-bin/references.cgi#GO_REF:0000004 GO_REF:0000004]
+GO_REF:0000004
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 IEA: Inferred from Electronic Annotation
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-[http://www.uniprot.org/keywords/KW-0406 SP_KW:KW-0406]
+SP_KW:KW-0406
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 P
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-[[Category:GO:0006810_!_transport]][http://gowiki.tamu.edu/wiki/index.php/Category:GO:0006810_!_transport GO:0006810]
+GO:0006810
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 transport
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-[http://www.geneontology.org/cgi-bin/references.cgi#GO_REF:0000004 GO_REF:0000004]
+GO_REF:0000004
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 IEA: Inferred from Electronic Annotation
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-[http://www.uniprot.org/keywords/KW-0813 SP_KW:KW-0813]
+SP_KW:KW-0813
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 P
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-[[Category:GO:0005247_!_voltage-gated_chloride_channel_activity]][http://gowiki.tamu.edu/wiki/index.php/Category:GO:0005247_!_voltage-gated_chloride_channel_activity GO:0005247]
+GO:0005247
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 voltage-gated chloride channel activity
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-[http://www.geneontology.org/cgi-bin/references.cgi#GO_REF:0000002 GO_REF:0000002]
+GO_REF:0000002
 |
 IEA: Inferred from Electronic Annotation
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-[http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR001807 InterPro:IPR001807]
+InterPro:IPR001807
 |
 F

clcA:Gene Product(s): Difference between revisions

Revision as of 19:22, 16 February 2009

Nomenclature

Notes

Function

Notes

Localization

Notes

Structure and Physical Properties

Notes

Gene Product Resources

Notes

Accessions in Other Databases

Notes

Links

References

Categories

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