htpX:Gene Product(s): Difference between revisions

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Domain
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32 - 54
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Predicted membrane-spanning helix.
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TMD predicted by [http://www.cbs.dtu.dk/services/TMHMM TMHMM]<ref name='PMID:11152613' />
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Domain
Domain
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32 - 54
158 - 180
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Predicted membrane-spanning helix.
Predicted membrane-spanning helix.

Revision as of 19:55, 21 October 2008

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
Nomenclature Function Interactions Localization Sequence Structure Resources Accessions Links References Suggestions

Nomenclature

Standard name

HtpX product

Synonyms

predicted endopeptidase product[1], B1829 product[2][1], HtpX product[2][1]

Product description

heat shock protein, integral membrane protein[2][3]

EC number (for enzymes)
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Notes

Function

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Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference(s) Evidence Code with/from Aspect Notes Status
GO:0016787

hydrolase activity

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0378

F

Seeded from EcoCyc 12.5 [4]

complete

GO:0016021

integral to membrane

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0812

C

Seeded from EcoCyc 12.5 [4]

complete

GO:0016020

membrane

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0472

C

Seeded from EcoCyc 12.5 [4]

complete

GO:0016020

membrane

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0397

C

Seeded from EcoCyc 12.5 [4]

complete

GO:0008233

peptidase activity

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0645

F

Seeded from EcoCyc 12.5 [4]

complete

GO:0008237

metallopeptidase activity

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0482

F

Seeded from EcoCyc 12.5 [4]

complete

GO:0008270

zinc ion binding

GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00188

F

Seeded from EcoCyc 12.5 [4]

complete

GO:0008270

zinc ion binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR009481

F

Seeded from EcoCyc 12.5 [4]

complete

GO:0008270

zinc ion binding

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0862

F

Seeded from EcoCyc 12.5 [4]

complete

GO:0016020

membrane

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001915

C

Seeded from EcoCyc 12.5 [4]

complete

GO:0006950

response to stress

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0346

P

Seeded from EcoCyc 12.5 [4]

complete

GO:0004222

metalloendopeptidase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001915

F

Seeded from EcoCyc 12.5 [4]

complete

GO:0004222

metalloendopeptidase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR009481

F

Seeded from EcoCyc 12.5 [4]

complete

GO:0006508

proteolysis

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001915

P

Seeded from EcoCyc 12.5 [4]

complete

GO:0004222

metalloendopeptidase activity

GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00188

F

Seeded from EcoCyc 12.5 [4]

complete

GO:0009266

response to temperature stimulus

P

Seeded from EcoCyc 11.1[3].

required fields missing

GO:0004222

metalloendopeptidase activity

PMID:16076848[5]

IDA: Inferred from Direct Assay

F

complete

GO:0046872

metal ion binding

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0479

F

Seeded from EcoCyc 12.5 [4]

complete

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Interactions

Partner Type Partner Notes
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See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Notes

HtpX is ATP-independent and introduces endoproteolytic cuts in abnormal membrane proteins

Localization

Compartment Description Evidence Notes

plasma membrane

plasma membrane

C-terminus localized in the cytoplasm with 4 predicted transmembrane domains

Daley et al. (2005) [6]


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See Help:Product_localization for how to add or edit information in this section of EcoliWiki.


Notes

Structure and Physical Properties

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Physical Properties

Sequence

at EcoCyc 

MMRIALFLLT NLAVMVVFGL VLSLTGIQSS SVQGLMIMAL LFGFGGSFVS LLMSKWMALR
SVGGEVIEQP RNERERWLVN TVATQARQAG IAMPQVAIYH APDINAFATG ARRDASLVAV
STGLLQNMSP DEAEAVIAHE ISHIANGDMV TMTLIQGVVN TFVIFISRIL AQLAAGFMGG
NRDEGEESNG NPLIYFAVAT VLELVFGILA SIITMWFSRH REFHADAGSA KLVGREKMIA
ALQRLKTSYE PQEATSMMAL CINGKSKSLS ELFMTHPPLD KRIEALRTGE YLK
Mol. Wt

31.92 kDa (calc) [2]

pI
Extinction coefficient

22460 - 22585 (calc based on 4 Y, 3 W, and 1 C residues)

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See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Domains/Motifs/Modification Sites

Type Residues Description Notes

Domain

32 - 54

Predicted membrane-spanning helix.

TMD predicted by TMHMM[7]

Domain

5 - 27

Predicted membrane-spanning helix.

TMD predicted by TMHMM[7]

Domain

158 - 180

Predicted membrane-spanning helix.

TMD predicted by TMHMM[7]

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See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

tmhmm.php?gene=htpX&show=pic&.jpg
Click the image to view raw output from TMHMM.

Structure

Structures

<beststructure>htpX 562</beststructure>

Models

View models at:

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See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Notes

Gene Product Resources

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Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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Database Accession Notes

EcoCyc (EcoliWiki Page)

EcoCyc:EG10462-MONOMER

UniProt (EcoliWiki Page)

UniProt:P23894

PFAM (EcoliWiki Page)

PFAM:PF06509

RefSeq (EcoliWiki Page)

RefSeq:NP_416343

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Notes

Links

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Name URL Comments
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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ 4.00 4.01 4.02 4.03 4.04 4.05 4.06 4.07 4.08 4.09 4.10 4.11 4.12 4.13 4.14 4.15 EcoCyc (release 12.5; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  5. ↑ Sakoh, M et al. (2005) Proteolytic activity of HtpX, a membrane-bound and stress-controlled protease from Escherichia coli. J. Biol. Chem. 280 33305-10 PubMed
  6. ↑ Daley, DO et al. (2005) Global topology analysis of the Escherichia coli inner membrane proteome. Science 308 1321-3 PubMed
  7. ↑ 7.0 7.1 7.2 Krogh, A et al. (2001) Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes. J. Mol. Biol. 305 567-80 PubMed


Categories

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