htpX:Gene Product(s): Difference between revisions

Standard name	HtpX product
Synonyms	predicted endopeptidase product^[1], B1829 product^[2]^[1], HtpX product^[2]^[1]
Product description	heat shock protein, integral membrane protein^[2]^[3]
EC number (for enzymes)
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Notes

Function

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Gene Ontology

Qualifier	GO ID	GO term name	Reference(s)	Evidence Code	with/from	Aspect	Notes	Status
	GO:0008233	peptidase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0645	F	Seeded from EcoCyc 12.5 ^[4]	complete
	GO:0008237	metallopeptidase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0482	F	Seeded from EcoCyc 12.5 ^[4]	complete
	GO:0008270	zinc ion binding	GO_REF:0000020	IEA: Inferred from Electronic Annotation	HAMAP:MF_00188	F	Seeded from EcoCyc 12.5 ^[4]	complete
	GO:0008270	zinc ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR009481	F	Seeded from EcoCyc 12.5 ^[4]	complete
	GO:0006950	response to stress	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0346	P	Seeded from EcoCyc 12.5 ^[4]	complete
	GO:0004222	metalloendopeptidase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001915	F	Seeded from EcoCyc 12.5 ^[4]	complete
	GO:0004222	metalloendopeptidase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR009481	F	Seeded from EcoCyc 12.5 ^[4]	complete
	GO:0006508	proteolysis	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001915	P	Seeded from EcoCyc 12.5 ^[4]	complete
	GO:0004222	metalloendopeptidase activity	GO_REF:0000020	IEA: Inferred from Electronic Annotation	HAMAP:MF_00188	F	Seeded from EcoCyc 12.5 ^[4]	complete
	GO:0009266	response to temperature stimulus				P	Seeded from EcoCyc 11.1^[3].	required fields missing
	GO:0004222	metalloendopeptidase activity	PMID:16076848^[5]	IDA: Inferred from Direct Assay		F		complete
	GO:0008270	zinc ion binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0862	F	Seeded from EcoCyc 12.5 ^[4]	complete
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Interactions

Partner Type	Partner	Notes
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Notes

HtpX is ATP-independent and introduces endoproteolytic cuts in abnormal membrane proteins

Localization

Compartment	Description	Evidence
plasma membrane
plasma membrane	C-terminus localized in the cytoplasm with 4 predicted transmembrane domains	Daley et al. (2005) ^[6]
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Notes

Structure and Physical Properties

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Physical Properties

Sequence	at EcoCyc MMRIALFLLT NLAVMVVFGL VLSLTGIQSS SVQGLMIMAL LFGFGGSFVS LLMSKWMALR SVGGEVIEQP RNERERWLVN TVATQARQAG IAMPQVAIYH APDINAFATG ARRDASLVAV STGLLQNMSP DEAEAVIAHE ISHIANGDMV TMTLIQGVVN TFVIFISRIL AQLAAGFMGG NRDEGEESNG NPLIYFAVAT VLELVFGILA SIITMWFSRH REFHADAGSA KLVGREKMIA ALQRLKTSYE PQEATSMMAL CINGKSKSLS ELFMTHPPLD KRIEALRTGE YLK
Mol. Wt	31.92 kDa (calc) ^[2]
pI
Extinction coefficient	22460 - 22585 (calc based on 4 Y, 3 W, and 1 C residues)
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Domains/Motifs/Modification Sites

Type	Residues	Description	Notes
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Structure

Structure Type	Organism	Accession	Residues covered	Notes
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Notes

Gene Product Resources

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Resource type	Source	Notes/Reference
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Notes

Accessions in Other Databases

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Database	Accession	Notes
EcoCyc (EcoliWiki Page)	EcoCyc:EG10462-MONOMER
UniProt (EcoliWiki Page)	UniProt:P23894
PFAM (EcoliWiki Page)	PFAM:PF06509
RefSeq (EcoliWiki Page)	RefSeq:NP_416343
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Notes

Links

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Name	URL	Comments
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References

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↑ ^1.0 ^1.1 ^1.2 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
↑ ^2.0 ^2.1 ^2.2 ^2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^3.0 ^3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^4.00 ^4.01 ^4.02 ^4.03 ^4.04 ^4.05 ^4.06 ^4.07 ^4.08 ^4.09 EcoCyc (release 12.5; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ Sakoh, M et al. (2005) Proteolytic activity of HtpX, a membrane-bound and stress-controlled protease from Escherichia coli. J. Biol. Chem. 280 33305-10 PubMed
↑ Daley, DO et al. (2005) Global topology analysis of the Escherichia coli inner membrane proteome. Science 308 1321-3 PubMed

htpX:Gene Product(s): Difference between revisions

Revision as of 21:52, 2 October 2008

Nomenclature

Notes

Function

Notes

Localization

Notes

Structure and Physical Properties

Notes

Gene Product Resources

Notes

Accessions in Other Databases

Notes

Links

References

Categories

Navigation menu

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 HAMAP:MF_00188
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+F
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+Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
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+complete
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+[[Category:GO:0008270_!_zinc_ion_binding]][http://gowiki.tamu.edu/wiki/index.php/Category:GO:0008270_!_zinc_ion_binding GO:0008270]
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+zinc ion binding
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+IEA: Inferred from Electronic Annotation
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+InterPro:IPR009481
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htpX:Gene Product(s): Difference between revisions

Revision as of 21:52, 2 October 2008

Nomenclature

Notes

Function

Notes

Localization

Notes

Structure and Physical Properties

Notes

Gene Product Resources

Notes

Accessions in Other Databases

Notes

Links

References

Categories

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