umuD:Quickview: Difference between revisions
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LexA regulon. Autocleavage removes the first 24 amino acids to form UmuD', required for mutageneic translesion synthesis (TLS). UmuD and UmuD' are | LexA regulon. Autocleavage removes the first 24 amino acids to form UmuD', required for mutageneic translesion synthesis (TLS). UmuD and UmuD' are intrinsically disordered proteins (IDPs) that can nonetheless form stable dimers (Simon, 2008)<ref name='PMID:18216271'/>.<ref name='LIB:EcoGene'/> A monomeric variant of UmuD has been identified that is active for cleavage to form UmuD' and for other functions <ref name='PMID:21118802'/>. | ||
Revision as of 22:46, 21 February 2011
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| Quickview | Gene | Gene Product(s) | Expression | Evolution | On One Page |
| References | Suggestions |
See Help:Quickview for help with entering information in the Quickview table.
| Standard Name |
umuD |
|---|---|
| Gene Synonym(s) |
ECK1171, b1183, JW1172, uvm[1] |
| Product Desc. |
SOS mutagenesis; error-prone repair; processed to UmuD'; forms complex with UmuC[2][3]; Component of DNA polymerase V[3] DNA polymerase V subunit, capable of translesion synthesis; inducible mutagenesis; error-prone repair; UmuDC single-stranded binding protein with RecA-coated DNA; intrinsic AP lyase activity[4] |
| Product Synonyms(s) | |
| Function from GO |
<GO_nr /> |
| Knock-Out Phenotype | |
| Regulation/Expression | |
| Regulation/Activity | |
| Quick Links | |
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Notes
LexA regulon. Autocleavage removes the first 24 amino acids to form UmuD', required for mutageneic translesion synthesis (TLS). UmuD and UmuD' are intrinsically disordered proteins (IDPs) that can nonetheless form stable dimers (Simon, 2008)[5].[4] A monomeric variant of UmuD has been identified that is active for cleavage to form UmuD' and for other functions [6].
References
- ↑ 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
- ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
- ↑ Simon, SM et al. (2008) Regulation of Escherichia coli SOS mutagenesis by dimeric intrinsically disordered umuD gene products. Proc. Natl. Acad. Sci. U.S.A. 105 1152-7 PubMed
- ↑ Ollivierre, JN et al. (2011) The dimeric SOS mutagenesis protein UmuD is active as a monomer. J. Biol. Chem. 286 3607-17 PubMed