DNA Replication: Difference between revisions

Revision as of 19:28, 28 June 2010

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Replication of the circular E.coli chromosome occurs bidirectionally from oriC.

There are several models for replication:

After replication, the daughter chromosomes must be segregated using various mechanisms.

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↑ Dingman, CW (1974) Bidirectional chromosome replication: some topological considerations. J. Theor. Biol. 43 187-95 PubMed
↑ Lemon, KP & Grossman, AD (1998) Localization of bacterial DNA polymerase: evidence for a factory model of replication. Science 282 1516-9 PubMed
↑ Lemon, KP & Grossman, AD (2000) Movement of replicating DNA through a stationary replisome. Mol. Cell 6 1321-30 PubMed

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 After replication, the daughter chromosomes must be [[Chromosome Segregation|segregated]] using various mechanisms.
-There are several models explaining how DNA segregates after it is replicated:
-*Extrusion Capture Model<ref name='PMID:11511534'/><ref name='PMID:11169104'/>
-*Sister Chromosome Cohesion Model<ref name='PMID:10886362'/><ref name='PMID:11886555'/><ref name='PMID:15960977'/>
-*Combination<ref name='PMID:12421305'/>
 ==Experimental Resources==