nrdE:Gene Product(s): Difference between revisions

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|-
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!align=left |Standard name
!align=left {{table heading style}} |Standard name
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NrdE  
NrdE  
|-
|-
!align=left |Synonyms
!align=left {{table heading style}} |Synonyms
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ribonucleoside-diphosphate reductase 2, alpha subunit<ref name='LIB:Riley_2006'/>, B2675<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, NrdE<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>  
ribonucleoside-diphosphate reductase 2, alpha subunit<ref name='LIB:Riley_2006'/>, B2675<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, NrdE<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>  
|-
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!align=left |Product description
!align=left {{table heading style}} |Product description
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NrdE<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>;  
NrdE<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>;  
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|-
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!align=left |EC number (for enzymes)
!align=left {{table heading style}} |EC number (for enzymes)
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* [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.17.4.1 1.17.4.1]<ref name='LIB:Riley_2006'/>
* [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.17.4.1 1.17.4.1]<ref name='LIB:Riley_2006'/>
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****************************************************************************************** -->{{Product_GO_help}}
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{|  id="X46aab5f36eaf2"  class=" tableEdit GO_table_product dataTable"   
{|  id="X46aab5f36eaf2"  class=" tableEdit GO_table_product dataTable"   
|-
|- {{table_heading_style}}
!|Qualifier!!GO ID!!GO term name!!Reference(s)!!Evidence Code!!with/from!!Aspect!!Notes!!Status
!|Qualifier!!GO ID!!GO term name!!Reference(s)!!Evidence Code!!with/from!!Aspect!!Notes!!Status
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*  
*  
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{|  id="H46aab5ff885de"  class=" tableEdit Product_interactions_table"   
{|  id="H46aab5ff885de"  class=" tableEdit Product_interactions_table dataTable"   
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|- {{table heading style}}
!|Partner Type!!Partner!!Notes!!References!!Evidence
!|Partner Type!!Partner!!Notes!!References!!Evidence
|-  
|-  
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{|  id="Q46a84d6f6194b"  class=" tableEdit Product_localization_table"   
{|  id="Q46a84d6f6194b"  class=" tableEdit Product_localization_table"   
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!|Compartment!!Description!!Evidence!!Source!!Notes
!|Compartment!!Description!!Evidence!!Source!!Notes


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|-
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!align=left |Sequence
!align=left {{table heading style}} |Sequence
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[http://biocyc.org/ECOLI/sequence-aa?object=NRDE-MONOMER at EcoCyc]  
[http://biocyc.org/ECOLI/sequence-aa?object=NRDE-MONOMER at EcoCyc]  
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LSLTLFFPDT ATTRDINKAQ IYAWRKGIKT LYYIRLRQMA LEGTEIEGCV SCAL</pre>  
LSLTLFFPDT ATTRDINKAQ IYAWRKGIKT LYYIRLRQMA LEGTEIEGCV SCAL</pre>  
|-
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!align=left |Length
!align=left {{table heading style}} |Length
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714
714
|-
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!align=left |Mol. Wt
!align=left {{table heading style}} |Mol. Wt
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80.481 kDa
80.481 kDa
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!align=left |pI
!align=left {{table heading style}} |pI
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6.5 (calculated)
6.5 (calculated)
|-
|-
!align=left |Extinction coefficient
!align=left {{table heading style}} |Extinction coefficient
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88,130 - 89,005 (calc based on 37 Y, 6 W, and 7 C residues)
88,130 - 89,005 (calc based on 37 Y, 6 W, and 7 C residues)
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*  
*  
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{|  id="E46aab602ddd53"  class=" tableEdit Product_motif_table"   
{|  id="E46aab602ddd53"  class=" tableEdit Product_motif_table dataTable"   
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|- {{table heading style}}
!|Type!!Residues!!Description!!Notes
!|Type!!Residues!!Description!!Notes!!References
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Removed (By similarity)
Removed (By similarity)
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[http://www.uniprot.org/uniprot/P39452#section_features UniProt:P39452]  
[http://www.uniprot.org/uniprot/P39452#section_features UniProt:P39452]
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|<span class="tableEdit_editLink plainlinks">[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.25648.E46aab602ddd53&page=25648&pagename={{FULLPAGENAMEE}}&type=&template=Product_motif_table edit table]</span> || || || ||
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|-
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!align=left |Structures
!align=left {{table heading style}} |Structures
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<beststructure>
<beststructure>
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</beststructure>
</beststructure>
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!align=left |Models
!align=left {{table heading style}} |Models
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View models at:
View models at:
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{|  id="P46aab603a7cc5"  class=" tableEdit Product_resource_table"   
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!|Resource type!!Source!!Notes/Reference
!|Resource type!!Source!!Notes/Reference


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{|  id="Q46aab60411ee1"  class=" tableEdit Gene_accessions_table"   
{|  id="Q46aab60411ee1"  class=" tableEdit Gene_accessions_table"   
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!|Database!!Accession!!Notes
!|Database!!Accession!!Notes
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!|Name!!URL!!Comments
!|Name!!URL!!Comments


Revision as of 20:34, 23 February 2010

{{#css:Suppresslinks.css}}<css>h1 .editsection { display:none;} h2 .editsection { display:none;}</css>

Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

NrdE

Synonyms

ribonucleoside-diphosphate reductase 2, alpha subunit[1], B2675[2][1], NrdE[2][1]

Product description

NrdE[2][3];

Component of ribonucleoside-diphosphate reductase 2, α subunit dimer[2][3]; ribonucleoside-diphosphate reductase 2[2][3]

EC number (for enzymes)
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Notes

Function

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Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference(s) Evidence Code with/from Aspect Notes Status
GO:0009263

deoxyribonucleotide biosynthetic process

PMID:7809142[4]

IGI: Inferred from Genetic Interaction

EcoliWiki:nrdA|EcoliWiki:nrdB

P

Seeded from EcoCyc [5]

complete

GO:0000166

nucleotide binding

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0547

F

Seeded from EcoCyc [5]

complete

GO:0003824

catalytic activity

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0021

F

Seeded from EcoCyc [5]

complete

GO:0004748

ribonucleoside-diphosphate reductase activity

GO_REF:0000002
GO_REF:0000002
GO_REF:0000002
GO_REF:0000003

IEA: Inferred from Electronic Annotation

InterPro:IPR000788
InterPro:IPR008926
InterPro:IPR013554
EC:1.17.4.1

F

Seeded from EcoCyc 12.5 [6]

complete

GO:0005515

protein binding

GO_REF:0000002
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR008926
InterPro:IPR013554

F

Seeded from EcoCyc [5]

complete

GO:0005524

ATP binding

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0067

F

Seeded from EcoCyc 12.5 [6]

complete

GO:0005971

ribonucleoside-diphosphate reductase complex

GO_REF:0000002
GO_REF:0000002
GO_REF:0000002
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000788
InterPro:IPR008926
InterPro:IPR013346
InterPro:IPR013554

C

Seeded from EcoCyc 12.5 [6]

complete

GO:0006260

DNA replication

GO_REF:0000002
GO_REF:0000002
GO_REF:0000002
GO_REF:0000004

IEA: Inferred from Electronic Annotation

InterPro:IPR000788
InterPro:IPR008926
InterPro:IPR013554
SP_KW:KW-0235

P

Seeded from EcoCyc 12.5 [6]

complete

GO:0016491

oxidoreductase activity

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0560

F

Seeded from EcoCyc [5]

complete

GO:0005737

cytoplasm

PMID:7809142[4]

ISA: Inferred from Sequence Alignment

UniProtKB:Q08698

C

complete

GO:0055114

oxidation reduction

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0560

P

Seeded from EcoCyc [5]

complete

GO:0015949

nucleobase, nucleoside and nucleotide interconversion

PMID:7809142[4]

IGI: Inferred from Genetic Interaction

EcoliWiki:nrdA|EcoliWiki:nrdB

P

A plasmid expressing nrdEFHI genes from Salmonella was capable of complementing nrdAB- mutations in E. coli.

complete

GO:0005524

ATP binding

GO:0016959

ISA: Inferred from Sequence Alignment

UniProtKB:Q08698

F

complete

Contributes to

GO:0016959

class I ribonucleotide reductase activity

PMID:7809142[4]

IGI: Inferred from Genetic Interaction

EcoliWiki:nrdA|EcoliWiki:nrdB

F

A plasmid expressing nrdEFHI genes from Salmonella was capable of complementing nrdAB- mutations in E. coli.

complete

Contributes to

GO:0004748

ribonucleoside-diphosphate reductase activity

PMID:7809142[4]

IGI: Inferred from Genetic Interaction

EcoliWiki:nrdA|EcoliWiki:nrdB

F

complete

GO:0005971

ribonucleoside-diphosphate reductase complex

PMID:7809142[4]

IGI: Inferred from Genetic Interaction

EcoliWiki:nrdA|EcoliWiki:nrdB

C

complete

GO:0009263

deoxyribonucleotide biosynthetic process

PMID:7809142[4]

IGI: Inferred from Genetic Interaction

EcoliWiki:nrdA|EcoliWiki:nrdB

P

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

Subunits of ribonucleoside-diphosphate reductase 2, α subunit dimer

could be indirect

Protein

intS

PMID:16606699[7]

Experiment(s):EBI-1143641

Protein

tusE

PMID:16606699[7]

Experiment(s):EBI-1143641

Protein

groL

PMID:16606699[7]

Experiment(s):EBI-1143641

Protein

yagA

PMID:16606699[7]

Experiment(s):EBI-1143641

Protein

ygeV

PMID:16606699[7]

Experiment(s):EBI-1143641

Protein

ydcS

PMID:16606699[7]

Experiment(s):EBI-1143641

Protein

ytfM

PMID:16606699[7]

Experiment(s):EBI-1143641

Protein

rplB

PMID:16606699[7]

Experiment(s):EBI-1143641

Protein

Subunits of ribonucleoside-diphosphate reductase 2

could be indirect


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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Source Notes
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Notes

Structure and Physical Properties

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Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Sequence

at EcoCyc 

MATTTAECLT QETMDYHALN AMLNLYDSAG RIQFDKDRQA VDAFIATHVR PNSVTFSSQQ
QRLNWLVNEG YYDESVLNRY SRDFVITLFT HAHTSGFRFQ TFLGAWKFYT SYTLKTFDGK
RYLEDFADRV TMVALTLAQG DETLALQLTD EMLSGRFQPA TPTFLNCGKQ QRGELVSCFL
LRIEDNMESI GRAVNSALQL SKRGGGVAFL LSNLREAGAP IKRIENQSSG VIPVMKMLED
AFSYANQLGA RQGAGAVYLH AHHPDILRFL DTKRENADEK IRIKTLSLGV VIPDITFHLA
KENAQMALFS PYDVERVYGK PFADVAISQH YDELVADERI RKKYLNARDF FQRLAEIQFE
SGYPYIMYED TVNRANPIAG RINMSNLCSE ILQVNSASEY DENLDYTRTG HDISCNLGSL
NIAHTMDSPD FARTVETAVR GLTAVSDMSH IRSVPSIEAG NAASHAIGLG QMNLHGYLAR
EGIAYGSPEA LDFTNLYFYA ITWHALRTSM LLARERGETF AGFKQSRYAS GEYFSQYLQG
NWQPKTAKVG ELFTRSGITL PTREMWAQLR DDVMRYGIYN QNLQAVPPTG SISYINHATS
SIHPIVAKVE IRKEGKTGRV YYPAPFMTNE NLALYQDAYE IGAEKIIDTY AEATRHVDQG
LSLTLFFPDT ATTRDINKAQ IYAWRKGIKT LYYIRLRQMA LEGTEIEGCV SCAL
Length

714

Mol. Wt

80.481 kDa

pI

6.5 (calculated)

Extinction coefficient

88,130 - 89,005 (calc based on 37 Y, 6 W, and 7 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Initiator Methionine

1

Removed (By similarity)

UniProt:P39452


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<motif_map/>

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=nrdE taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

EcoCyc (EcoliWiki Page)

EcoCyc:NRDE-MONOMER

SwissModel (EcoliWiki Page)

SwissModel:P39452

UniProt (EcoliWiki Page)

UniProt:P39452

PFAM (EcoliWiki Page)

PFAM:PF00317

RefSeq (EcoliWiki Page)

RefSeq:NP_417161


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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 3.2 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ 4.0 4.1 4.2 4.3 4.4 4.5 4.6 Jordan, A et al. (1994) A second class I ribonucleotide reductase in Enterobacteriaceae: characterization of the Salmonella typhimurium enzyme. Proc. Natl. Acad. Sci. U.S.A. 91 12892-6 PubMed
  5. ↑ 5.0 5.1 5.2 5.3 5.4 5.5 EcoCyc (release 13.0; 2009) Keseler, IM et al. (2009) Nucleic Acids Res. 37(Database issue):D464-70
  6. ↑ 6.0 6.1 6.2 6.3 EcoCyc (release 12.5; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  7. ↑ 7.0 7.1 7.2 7.3 7.4 7.5 7.6 7.7 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed

Categories

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