metB:Gene Product(s): Difference between revisions

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|-
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!align=left |Standard name
!align=left {{table heading style}} |Standard name
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MetB  
MetB  
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!align=left |Synonyms
!align=left {{table heading style}} |Synonyms
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cystathionine gamma-synthase, PLP-dependent<ref name='LIB:Riley_2006'/>, B3939<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, MetB<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>  
cystathionine gamma-synthase, PLP-dependent<ref name='LIB:Riley_2006'/>, B3939<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, MetB<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>  
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!align=left |Product description
!align=left {{table heading style}} |Product description
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MetB<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>;  
MetB<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>;  
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Cystathionine gamma-synthase; homotetrameric<ref name='LIB:EcoGene'/>
Cystathionine gamma-synthase; homotetrameric<ref name='LIB:EcoGene'/>
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!align=left |EC number (for enzymes)
!align=left {{table heading style}} |EC number (for enzymes)
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  [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.48 2.5.1.48]<ref name='LIB:Riley_2006'/>
  [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.48 2.5.1.48]<ref name='LIB:Riley_2006'/>
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****************************************************************************************** -->{{Product_GO_help}}
****************************************************************************************** -->{{Product_GO_help}}
{|  id="G46ab0f65b0735"  class=" tableEdit GO_table_product dataTable"   
{|  id="G46ab0f65b0735"  class=" tableEdit GO_table_product dataTable"   
|-
|- {{table_heading_style}}
!|Qualifier!!GO ID!!GO term name!!Reference(s)!!Evidence Code!!with/from!!Aspect!!Notes!!Status
!|Qualifier!!GO ID!!GO term name!!Reference(s)!!Evidence Code!!with/from!!Aspect!!Notes!!Status
|-  
|-  
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*  
*  
****************************************************************************************** -->{{Product_interactions_help}}
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{|  id="N46ab0f7bb6241"  class=" tableEdit Product_interactions_table"   
{|  id="N46ab0f7bb6241"  class=" tableEdit Product_interactions_table dataTable"   
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|- {{table heading style}}
!|Partner Type!!Partner!!Notes!!References!!Evidence
!|Partner Type!!Partner!!Notes!!References!!Evidence
|-  
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{|  id="Q46a8976fbf72d"  class=" tableEdit Product_localization_table"   
{|  id="Q46a8976fbf72d"  class=" tableEdit Product_localization_table"   
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|- {{table heading style}}
!|Compartment!!Description!!Evidence!!Source!!Notes
!|Compartment!!Description!!Evidence!!Source!!Notes


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|-
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!align=left |Sequence
!align=left {{table heading style}} |Sequence
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[http://biocyc.org/ECOLI/sequence-aa?object=O-SUCCHOMOSERLYASE-MONOMER at EcoCyc]  
[http://biocyc.org/ECOLI/sequence-aa?object=O-SUCCHOMOSERLYASE-MONOMER at EcoCyc]  
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RISTGIEDGE DLIADLENGF RAANKG</pre>  
RISTGIEDGE DLIADLENGF RAANKG</pre>  
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!align=left |Length
!align=left {{table heading style}} |Length
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386
386
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!align=left |Mol. Wt
!align=left {{table heading style}} |Mol. Wt
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41.55 kDa
41.55 kDa
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!align=left |pI
!align=left {{table heading style}} |pI
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6.4 (calculated)
6.4 (calculated)
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!align=left |Extinction coefficient
!align=left {{table heading style}} |Extinction coefficient
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25,900 - 26,525 (calc based on 10 Y, 2 W, and 5 C residues)
25,900 - 26,525 (calc based on 10 Y, 2 W, and 5 C residues)
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*  
*  
****************************************************************************************** -->{{Product_domains_motifs_help}}
****************************************************************************************** -->{{Product_domains_motifs_help}}
{|  id="B46ab0f7ec82b7"  class=" tableEdit Product_motif_table"   
{|  id="B46ab0f7ec82b7"  class=" tableEdit Product_motif_table dataTable"   
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|- {{table heading style}}
!|Type!!Residues!!Description!!Notes
!|Type!!Residues!!Description!!Notes!!References


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|-
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!align=left |Structures
!align=left {{table heading style}} |Structures
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<beststructure>
<beststructure>
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</beststructure>
</beststructure>
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!align=left |Models
!align=left {{table heading style}} |Models
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View models at:
View models at:
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{|  id="U46ab0f7fa2748"  class=" tableEdit Product_resource_table"   
{|  id="U46ab0f7fa2748"  class=" tableEdit Product_resource_table"   
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!|Resource type!!Source!!Notes/Reference
!|Resource type!!Source!!Notes/Reference


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{|  id="S46ab0f8013cab"  class=" tableEdit Gene_accessions_table"   
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!|Database!!Accession!!Notes
!|Database!!Accession!!Notes
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!|Name!!URL!!Comments
!|Name!!URL!!Comments


Revision as of 20:26, 23 February 2010

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

MetB

Synonyms

cystathionine gamma-synthase, PLP-dependent[1], B3939[2][1], MetB[2][1]

Product description

MetB[2][3];

Component of O-SUCCHOMOSERLYASE-CPLX[2]

Cystathionine gamma-synthase; homotetrameric[4]

EC number (for enzymes) 
2.5.1.48[1]
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Notes

Function

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Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference(s) Evidence Code with/from Aspect Notes Status
GO:0005515

protein binding

PMID:16606699[5]

IPI: Inferred from Physical Interaction

UniProtKB:P18843

F

Seeded from EcoCyc [6]

complete

GO:0003824

catalytic activity

GO_REF:0000002
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR015421
InterPro:IPR015422

F

Seeded from EcoCyc [6]

complete

GO:0003962

cystathionine gamma-synthase activity

GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:2.5.1.48

F

Seeded from EcoCyc [6]

complete

GO:0005737

cytoplasm

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0963

C

Seeded from EcoCyc 12.5 [7]

complete

GO:0006520

amino acid metabolic process

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000277

P

Seeded from EcoCyc [6]

complete

GO:0008652

amino acid biosynthetic process

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0028

P

Seeded from EcoCyc [6]

complete

GO:0009086

methionine biosynthetic process

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0486

P

Seeded from EcoCyc [6]

complete

GO:0016740

transferase activity

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0808

F

Seeded from EcoCyc [6]

complete

GO:0030170

pyridoxal phosphate binding

GO_REF:0000002
GO_REF:0000002
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000277
InterPro:IPR015421
InterPro:IPR015422

F

Seeded from EcoCyc [6]

complete

GO:0009063

amino acid catabolic process

P

Seeded from EcoCyc 11.1[3].

required fields missing

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

Subunits of O-SUCCHOMOSERLYASE-CPLX

could be indirect

Protein

nadE

PMID:16606699[5]

Experiment(s):EBI-1147115
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Notes

metB1 is a mutant brought about by X-ray mutagenesis and is most likely a deletion mutation.

The metB1 mutation causes a requirement for methionine and produces no enzymatic activity. [8]

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Source Notes
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Notes

Structure and Physical Properties

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Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Sequence

at EcoCyc 

MTRKQATIAV RSGLNDDEQY GCVVPPIHLS STYNFTGFNE PRAHDYSRRG NPTRDVVQRA
LAELEGGAGA VLTNTGMSAI HLVTTVFLKP GDLLVAPHDC YGGSYRLFDS LAKRGCYRVL
FVDQGDEQAL RAALAEKPKL VLVESPSNPL LRVVDIAKIC HLAREVGAVS VVDNTFLSPA
LQNPLALGAD LVLHSCTKYL NGHSDVVAGV VIAKDPDVVT ELAWWANNIG VTGGAFDSYL
LLRGLRTLVP RMELAQRNAQ AIVKYLQTQP LVKKLYHPSL PENQGHEIAA RQQKGFGAML
SFELDGDEQT LRRFLGGLSL FTLAESLGGV ESLISHAATM THAGMAPEAR AAAGISETLL
RISTGIEDGE DLIADLENGF RAANKG
Length

386

Mol. Wt

41.55 kDa

pI

6.4 (calculated)

Extinction coefficient

25,900 - 26,525 (calc based on 10 Y, 2 W, and 5 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References
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<motif_map/>

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=metB taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

EcoCyc (EcoliWiki Page)

EcoCyc:O-SUCCHOMOSERLYASE-MONOMER

UniProt (EcoliWiki Page)

UniProt:P00935

PFAM (EcoliWiki Page)

PFAM:PF01053

RefSeq (EcoliWiki Page)

RefSeq:NP_418374


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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ 5.0 5.1 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
  6. ↑ 6.0 6.1 6.2 6.3 6.4 6.5 6.6 6.7 EcoCyc (release 13.0; 2009) Keseler, IM et al. (2009) Nucleic Acids Res. 37(Database issue):D464-70
  7. ↑ EcoCyc (release 12.5; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  8. ↑ Hall, BG (1989) Selection, adaptation, and bacterial operons. Genome 31 265-71 PubMed

Categories

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