groL:Quickview: Difference between revisions

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!align=left {{table_heading_style}} |Function from GO
!align=left {{table_heading_style}} |Function from GO
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'''Molecular Function'''
<GO_nr />
* GO:0005515 protein binding ([http://www.geneontology.org/GO.evidence.shtml IPI])
* GO:0016887 ATPase activity ([http://www.geneontology.org/GO.evidence.shtml IDA])
'''Biological Process'''
* GO:0042963 phage assembly ([http://www.geneontology.org/GO.evidence.shtml IMP])
* GO:0009408 response to heat ([http://www.geneontology.org/GO.evidence.shtml IEP])
'''Cellular Component'''
* GO:0005829 cytosol ([http://www.geneontology.org/GO.evidence.shtml IDA])
 
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!align=left {{table_heading_style}} |Knock-Out Phenotype
!align=left {{table_heading_style}} |Knock-Out Phenotype

Revision as of 19:39, 2 February 2010

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
References Suggestions

See Help:Quickview for help with entering information in the Quickview table.

Standard Name

groL

Gene Synonym(s)

ECK4137, b4143, JW4103, groEL, mopB, groE, hdh, mopA, tabB[1][2]

Product Desc.

GroEL, chaperone Hsp60, peptide-dependent ATPase, heat shock protein[2][3];

Component of GroEL-GroES Chaperonin-CPLX[3]

Chaperonin Cpn60; phage morphogenesis; GroESL large subunit GroEL, weak ATPase; binds Ap4A[4]

Product Synonyms(s)

Cpn60 chaperonin GroEL, large subunit of GroESL product[1], B4143 product[2][1], Hdh product[2][1], TabB product[2][1], GroL product[2][1], MopA product[2][1], GroEL product[2][1]

Function from GO

<GO_nr />

Knock-Out Phenotype
Regulation/Expression

transcription unit(s): groS[2], groS, groES

Regulation/Activity
Quick Links

DNA display    Protein display    Pubmed(groL)    Textpresso(groL)

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See Help:Quickview for help with entering information in the Quickview table.

Notes

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groL is an essential gene. GroEL binds and regulates rpoH. Cells deficient in GroEL and GroES lyse due to inability to produce cell wall as a result of the reduced level of DapA, the first enzyme in the DAP synthesis pathway. Growth below 8C is impaired due to GroESL inactivation and can be rescued by transgenic Oleispira antarctica Cpn10/60. Overproduction of GroESL can supress tig/dnaK synthetic lethality at 30 degrees C.[4]



References

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  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
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