groL:Quickview: Difference between revisions

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!align=left |Standard Name
!align=left {{table_heading_style}} |Standard Name
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''groL''  
''groL''  
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!align=left |Gene Synonym(s)
!align=left {{table_heading_style}} |Gene Synonym(s)
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''ECK4137, b4143, JW4103, groEL, mopB, groE, hdh, mopA, tabB''<ref name='LIB:Riley_2006'/><ref name='LIB:EcoCyc10.6'/>
''ECK4137, b4143, JW4103, groEL, mopB, groE, hdh, mopA, tabB''<ref name='LIB:Riley_2006'/><ref name='LIB:EcoCyc10.6'/>
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!align=left |Product Desc.
!align=left {{table_heading_style}} |Product Desc.
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GroEL, chaperone Hsp60, peptide-dependent ATPase, heat shock protein<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>;  
GroEL, chaperone Hsp60, peptide-dependent ATPase, heat shock protein<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>;  
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Chaperonin Cpn60; phage morphogenesis; GroESL large subunit GroEL, weak ATPase; binds Ap4A<ref name='LIB:EcoGene'/>
Chaperonin Cpn60; phage morphogenesis; GroESL large subunit GroEL, weak ATPase; binds Ap4A<ref name='LIB:EcoGene'/>
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!align=left |Product Synonyms(s)
!align=left {{table_heading_style}} |Product Synonyms(s)
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Cpn60 chaperonin GroEL, large subunit of GroESL product<ref name='LIB:Riley_2006'/>, B4143 product<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, Hdh product<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, TabB product<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, GroL product<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, MopA product<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, GroEL product<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>  
Cpn60 chaperonin GroEL, large subunit of GroESL product<ref name='LIB:Riley_2006'/>, B4143 product<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, Hdh product<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, TabB product<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, GroL product<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, MopA product<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, GroEL product<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>  
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!align=left |Knock-Out Phenotype
!align=left {{table_heading_style}} |Function from GO
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'''Molecular Function'''
* GO:0005515 protein binding ([http://www.geneontology.org/GO.evidence.shtml IPI])
* GO:0016887 ATPase activity ([http://www.geneontology.org/GO.evidence.shtml IDA])
'''Biological Process'''
* GO:0042963 phage assembly ([http://www.geneontology.org/GO.evidence.shtml IMP])
* GO:0009408 response to heat ([http://www.geneontology.org/GO.evidence.shtml IEP])
'''Cellular Component'''
* GO:0005829 cytosol ([http://www.geneontology.org/GO.evidence.shtml IDA])


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!align=left |Regulation/Expression
!align=left {{table_heading_style}} |Knock-Out Phenotype
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!align=left {{table_heading_style}} |Regulation/Expression
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transcription unit(s): [[:Category:Txn_unit:groS|groS]]<ref name='LIB:EcoCyc10.6'/>, groS, groES  
transcription unit(s): [[:Category:Txn_unit:groS|groS]]<ref name='LIB:EcoCyc10.6'/>, groS, groES  
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!align=left |Regulation/Activity
!align=left {{table_heading_style}} |Regulation/Activity
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!align=left {{table_heading_style}} |Quick Links
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[http://ecoliwiki.net/tools/display_dna.php?gene=groL&loc=MG1655:4369048..4370694,W3110:4375705..4377351,DH10B:4469410..4471056,REL606:4349746..4351392 DNA display]&nbsp;&nbsp;&nbsp; [http://ecoliwiki.net/tools/display_protein.php?f=NC_000913&start=4349746&end=4351392&gene=groL&aa=maakdvkfgndarvkmlrgvnvladavkvtlgpkgrnvvldksfgaptitkdgvsvareieledkfenmgaqmvkevaskandaagdgtttatvlaqaiiteglkavaagmnpmdlkrgidkavtaaveelkalsvpcsdskaiaqvgtisansdetvgkliaeamdkvgkegvitvedgtglqdeldvvegmqfdrgylspyfinkpetgavelespfilladkkisniremlpvleavakagkplliiaedvegealatlvvntmrgivkvaavkapgfgdrrkamlqdiatltggtviseeigmelekatledlgqakrvvinkdtttiidgvgeeaaiqgrvaqirqqieeatsdydreklqervaklaggvavikvgaatevemkekkarvedalhatraaveegvvagggvalirvaskladlrgqnedqnvgikvalrameaplrqivlncgeepsvvantvkggdgnygynaateeygnmidmgildptkvtrsalqyaasvaglmittecmvtdlpkndaadlgaaggmggmggmggmm Protein display]&nbsp;&nbsp;&nbsp; [http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Search&Term=groL+AND+escherichia+coli Pubmed(groL)]&nbsp;&nbsp;&nbsp; [http://trimer.tamu.edu/cgi-bin/textpresso/2.1/ecoli/search?searchstring=groL Textpresso(groL)]


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Revision as of 23:54, 21 January 2010

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
References Suggestions

See Help:Quickview for help with entering information in the Quickview table.

Standard Name

groL

Gene Synonym(s)

ECK4137, b4143, JW4103, groEL, mopB, groE, hdh, mopA, tabB[1][2]

Product Desc.

GroEL, chaperone Hsp60, peptide-dependent ATPase, heat shock protein[2][3];

Component of GroEL-GroES Chaperonin-CPLX[3]

Chaperonin Cpn60; phage morphogenesis; GroESL large subunit GroEL, weak ATPase; binds Ap4A[4]

Product Synonyms(s)

Cpn60 chaperonin GroEL, large subunit of GroESL product[1], B4143 product[2][1], Hdh product[2][1], TabB product[2][1], GroL product[2][1], MopA product[2][1], GroEL product[2][1]

Function from GO

Molecular Function

Biological Process

Cellular Component

Knock-Out Phenotype
Regulation/Expression

transcription unit(s): groS[2], groS, groES

Regulation/Activity
Quick Links

DNA display    Protein display    Pubmed(groL)    Textpresso(groL)

edit table

See Help:Quickview for help with entering information in the Quickview table.

Notes

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groL is an essential gene. GroEL binds and regulates rpoH. Cells deficient in GroEL and GroES lyse due to inability to produce cell wall as a result of the reduced level of DapA, the first enzyme in the DAP synthesis pathway. Growth below 8C is impaired due to GroESL inactivation and can be rescued by transgenic Oleispira antarctica Cpn10/60. Overproduction of GroESL can supress tig/dnaK synthetic lethality at 30 degrees C.[4]



References

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  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
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