lepA:Quickview: Difference between revisions

From EcoliWiki
Jump to navigation Jump to search
← Older editNewer edit →
Update TableEdit tables.
update QV table
Line 27: Line 27:


|-
|-
!align=left |Standard Name
!align=left {{table_heading_style}} |Standard Name
||
||
''lepA''  
''lepA''  
|-
|-
!align=left |Gene Synonym(s)
!align=left {{table_heading_style}} |Gene Synonym(s)
||
||
''ECK2567, b2569, JW2553''<ref name='LIB:Riley_2006'/>
''ECK2567, b2569, JW2553''<ref name='LIB:Riley_2006'/>
|-
|-
!align=left |Product Desc.
!align=left {{table_heading_style}} |Product Desc.
||
||
GTP-binding membrane protein<ref name='LIB:EcoCyc10.6'/>; elongation factor 4<ref name='LIB:EcoCyc11.1'/>
GTP-binding membrane protein<ref name='LIB:EcoCyc10.6'/>; elongation factor 4<ref name='LIB:EcoCyc11.1'/>
Line 41: Line 41:
Back-translocating Elongation Factor EF4, GTPase; required for efficient and accurate protein synthesis<ref name='LIB:EcoGene'/>
Back-translocating Elongation Factor EF4, GTPase; required for efficient and accurate protein synthesis<ref name='LIB:EcoGene'/>
|-
|-
!align=left |Product Synonyms(s)
!align=left {{table_heading_style}} |Product Synonyms(s)
||
||
GTP-binding membrane protein<ref name='LIB:Riley_2006'/>, B2569<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, LepA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, EF4<ref name='LIB:EcoCyc11.1'/><ref name='LIB:Riley_2006'/>  
GTP-binding membrane protein<ref name='LIB:Riley_2006'/>, B2569<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, LepA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, EF4<ref name='LIB:EcoCyc11.1'/><ref name='LIB:Riley_2006'/>  
|-
|-
!align=left |Knock-Out Phenotype
!align=left {{table_heading_style}} |Function from GO
||
||
'''Molecular Function'''
* GO:0003746 translation elongation factor activity ([http://www.geneontology.org/GO.evidence.shtml IDA])
* GO:0003924 GTPase activity ([http://www.geneontology.org/GO.evidence.shtml IDA])
'''Biological Process'''
* GO:0006414 translational elongation ([http://www.geneontology.org/GO.evidence.shtml IDA])


|-
|-
!align=left |Regulation/Expression
!align=left {{table_heading_style}} |Knock-Out Phenotype
||
 
|-
!align=left {{table_heading_style}} |Regulation/Expression
||
||
transcription unit(s): [[:Category:Txn_unit:lepAB|lepAB]]<ref name='LIB:EcoCyc10.6'/>  
transcription unit(s): [[:Category:Txn_unit:lepAB|lepAB]]<ref name='LIB:EcoCyc10.6'/>  
|-
|-
!align=left |Regulation/Activity
!align=left {{table_heading_style}} |Regulation/Activity
||
||


|-
!align=left {{table_heading_style}} |Quick Links
||
[http://ecoliwiki.net/tools/display_dna.php?gene=lepA&loc=MG1655:2705146..2703347,W3110:2705780..2703981,REL606:2628617..2626818,DH10B:2796911..2795112 DNA display]&nbsp;&nbsp;&nbsp; [http://ecoliwiki.net/tools/display_protein.php?f=NC_000913&start=2796911&end=2795112&gene=lepA&aa=mknirnfsiiahidhgkstlsdriiqicgglsdremeaqvldsmdlerergitikaqsvtldykasdgetyqlnfidtpghvdfsyevsrslaacegallvvdagqgveaqtlancytamemdlevvpvlnkidlpaadpervaeeiedivgidatdavrcsaktgvgvqdvlerlvrdipppegdpegplqaliidswfdnylgvvslirikngtlrkgdkvkvmstgqtynadrlgiftpkqvdrtelkcgevgwlvcaikdihgapvgdtltlarnpaekalpgfkkvkpqvyaglfpvssddyeafrdalgklslndaslfyepesssalgfgfrcgflgllhmeiiqerlereydldlittaptvvyevettsreviyvdspsklpavnniyelrepiaechmllpqaylgnvitlcvekrgvqtnmvyhgnqvaltyeipmaevvldffdrlkstsrgyasldynfkrfqasdmvrvdvlingervdalalithrdnsqnrgrelvekmkdliprqqfdiaiqaaigthiiarstvkqlrknvlakcyggdisrkkkllqkqkegkkrmkqignvelpqeaflailhvgkdnk Protein display]&nbsp;&nbsp;&nbsp; [http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Search&Term=lepA+AND+escherichia+coli Pubmed(lepA)]&nbsp;&nbsp;&nbsp; [http://trimer.tamu.edu/cgi-bin/textpresso/2.1/ecoli/search?searchstring=lepA Textpresso(lepA)]


|- class="tableEdit_footer"  
|- class="tableEdit_footer"  

Revision as of 23:47, 21 January 2010

{{#css:Suppresslinks.css}}<css>h1 .editsection { display:none;} h2 .editsection { display:none;}</css>

Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
References Suggestions

See Help:Quickview for help with entering information in the Quickview table.

Standard Name

lepA

Gene Synonym(s)

ECK2567, b2569, JW2553[1]

Product Desc.

GTP-binding membrane protein[2]; elongation factor 4[3]

Back-translocating Elongation Factor EF4, GTPase; required for efficient and accurate protein synthesis[4]

Product Synonyms(s)

GTP-binding membrane protein[1], B2569[2][1], LepA[2][1], EF4[3][1]

Function from GO

Molecular Function

Biological Process

Knock-Out Phenotype
Regulation/Expression

transcription unit(s): lepAB[2]

Regulation/Activity
Quick Links

DNA display    Protein display    Pubmed(lepA)    Textpresso(lepA)

edit table

See Help:Quickview for help with entering information in the Quickview table.

Notes

[back to top]


Although EF4 improves translational accuracy, it can not reverse paromomycin-induced errors (Qin, 2006). EF4 is a widely conserved protein, the first four domains are related to EF-G domains I, II, III, and V (Qin, 2006). EF4 overexpression is toxic (Qin 2006). EF4 (LepA) is in the lepAB operon but has no known role in signal peptidase I (LepB) activity.[4]



References

[back to top]


  1. ↑ 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
Retrieved from "https://ecoliwiki.org/colipedia/index.php?title=lepA:Quickview&oldid=1031334"