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!align=left |Standard Name
!align=left {{table_heading_style}} |Standard Name
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''lexA''  
''lexA''  
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!align=left |Gene Synonym(s)
!align=left {{table_heading_style}} |Gene Synonym(s)
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''ECK4035, b4043, JW4003, exrA, tsl, umuA''<ref name='LIB:Riley_2006'/>
''ECK4035, b4043, JW4003, exrA, tsl, umuA''<ref name='LIB:Riley_2006'/>
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!align=left |Product Desc.
!align=left {{table_heading_style}} |Product Desc.
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LexA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>;  
LexA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>;  
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Global regulator (repressor) for SOS regulon; dimeric<ref name='LIB:EcoGene'/>
Global regulator (repressor) for SOS regulon; dimeric<ref name='LIB:EcoGene'/>
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!align=left |Product Synonyms(s)
!align=left {{table_heading_style}} |Product Synonyms(s)
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DNA-binding transcriptional repressor of SOS regulon<ref name='LIB:Riley_2006'/>, B4043<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, Tsl<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, UmuA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, ExrA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, LexA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>  
DNA-binding transcriptional repressor of SOS regulon<ref name='LIB:Riley_2006'/>, B4043<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, Tsl<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, UmuA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, ExrA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, LexA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>  
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!align=left |Knock-Out Phenotype
!align=left {{table_heading_style}} |Function from GO
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'''Molecular Function'''
* GO:0005515 protein binding ([http://www.geneontology.org/GO.evidence.shtml IPI])
* GO:0016564 transcription repressor activity ([http://www.geneontology.org/GO.evidence.shtml IMP,IDA])
* GO:0003677 DNA binding ([http://www.geneontology.org/GO.evidence.shtml IDA])
'''Biological Process'''
* GO:0006350 transcription ([http://www.geneontology.org/GO.evidence.shtml IMP,IDA])


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!align=left |Regulation/Expression
!align=left {{table_heading_style}} |Knock-Out Phenotype
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!align=left {{table_heading_style}} |Regulation/Expression
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transcription unit(s): [[:Category:Txn_unit:lexA-dinF|lexA-dinF]]<ref name='LIB:EcoCyc10.6'/>, OP00046, lexA  
transcription unit(s): [[:Category:Txn_unit:lexA-dinF|lexA-dinF]]<ref name='LIB:EcoCyc10.6'/>, OP00046, lexA  
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!align=left |Regulation/Activity
!align=left {{table_heading_style}} |Regulation/Activity
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!align=left {{table_heading_style}} |Quick Links
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[http://ecoliwiki.net/tools/display_dna.php?gene=lexA&loc=MG1655:4255138..4255746,W3110:4260705..4261313,DH10B:4354834..4355442,REL606:4236047..4236655 DNA display]&nbsp;&nbsp;&nbsp; [http://ecoliwiki.net/tools/display_protein.php?f=NC_000913&start=4236047&end=4236655&gene=lexA&aa=mkaltarqqevfdlirdhisqtgmpptraeiaqrlgfrspnaaeehlkalarkgvieivsgasrgirllqeeeeglplvgrvaagepllaqqhieghyqvdpslfkpnadfllrvsgmsmkdigimdgdllavhktqdvrngqvvvariddevtvkrlkkqgnkvellpensefkpivvdlrqqsftieglavgvirngdwl Protein display]&nbsp;&nbsp;&nbsp; [http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Search&Term=lexA+AND+escherichia+coli Pubmed(lexA)]&nbsp;&nbsp;&nbsp; [http://trimer.tamu.edu/cgi-bin/textpresso/2.1/ecoli/search?searchstring=lexA Textpresso(lexA)]


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Revision as of 23:47, 21 January 2010

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
References Suggestions

See Help:Quickview for help with entering information in the Quickview table.

Standard Name

lexA

Gene Synonym(s)

ECK4035, b4043, JW4003, exrA, tsl, umuA[1]

Product Desc.

LexA[2][3];

Component of LexA transcriptional repressor[2][3]

Global regulator (repressor) for SOS regulon; dimeric[4]

Product Synonyms(s)

DNA-binding transcriptional repressor of SOS regulon[1], B4043[2][1], Tsl[2][1], UmuA[2][1], ExrA[2][1], LexA[2][1]

Function from GO

Molecular Function

Biological Process

Knock-Out Phenotype
Regulation/Expression

transcription unit(s): lexA-dinF[2], OP00046, lexA

Regulation/Activity
Quick Links

DNA display    Protein display    Pubmed(lexA)    Textpresso(lexA)

edit table

See Help:Quickview for help with entering information in the Quickview table.

Notes

[back to top]


LexA autocleavage, stimulated by RecA, of the first 84 aa of LexA removes the DNA binding region and is required to activate the SOS response. LexA recognition site: CTGTATATATATACAG.[4]



References

[back to top]


  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
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