rppH:Quickview: Difference between revisions
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!align=left | !align=left {{table_heading_style}} |Standard Name | ||
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''rppH'' <ref name='PMID:18202662'/> | ''rppH'' <ref name='PMID:18202662'/> | ||
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!align=left | !align=left {{table_heading_style}} |Gene Synonym(s) | ||
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''nudH, ECK2826, b2830, JW2798, ydgP, ygdP''<ref name='LIB:Riley_2006'/> | ''nudH, ECK2826, b2830, JW2798, ydgP, ygdP''<ref name='LIB:Riley_2006'/> | ||
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!align=left | !align=left {{table_heading_style}} |Product Desc. | ||
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RNA pyrophosphohydrolase (removes the 5'-pyrophosphate from mRNAs and initiates degradation by the 5'-end dependent pathway)<ref name='PMID:18202662'/>; putative invasion protein<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/> | RNA pyrophosphohydrolase (removes the 5'-pyrophosphate from mRNAs and initiates degradation by the 5'-end dependent pathway)<ref name='PMID:18202662'/>; putative invasion protein<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/> | ||
RNA pyrophosphohydrolase, destabilizes primary transcripts<ref name='LIB:EcoGene'/> | RNA pyrophosphohydrolase, destabilizes primary transcripts<ref name='LIB:EcoGene'/> | ||
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!align=left | !align=left {{table_heading_style}} |Product Synonyms(s) | ||
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NudH,nucleotide hydrolase<ref name='LIB:Riley_2006'/>, B2830<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, NudH<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, YgdP<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/> | NudH,nucleotide hydrolase<ref name='LIB:Riley_2006'/>, B2830<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, NudH<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, YgdP<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/> | ||
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!align=left | !align=left {{table_heading_style}} |Function from GO | ||
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'''Biological Process''' | |||
* GO:0050779 RNA destabilization ([http://www.geneontology.org/GO.evidence.shtml IMP]) | |||
* GO:0050779 RNA_destabilization ([http://www.geneontology.org/GO.evidence.shtml IMP]) | |||
'''Molecular Function''' | |||
* GO:0034353 RNA pyrophosphohydrolase activity ([http://www.geneontology.org/GO.evidence.shtml IDA]) | |||
* GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides ([http://www.geneontology.org/GO.evidence.shtml IDA]) | |||
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!align=left {{table_heading_style}} |Knock-Out Phenotype | |||
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Many mRNAs have an increased half-life. <ref name='PMID:18202662'/> | Many mRNAs have an increased half-life. <ref name='PMID:18202662'/> | ||
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!align=left | !align=left {{table_heading_style}} |Regulation/Expression | ||
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transcription unit(s): [[:Category:Txn_unit:ptsP|ptsP]]<ref name='LIB:EcoCyc10.6'/> | transcription unit(s): [[:Category:Txn_unit:ptsP|ptsP]]<ref name='LIB:EcoCyc10.6'/> | ||
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!align=left | !align=left {{table_heading_style}} |Regulation/Activity | ||
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!align=left {{table_heading_style}} |Quick Links | |||
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[http://ecoliwiki.net/tools/display_dna.php?gene=rppH&loc=MG1655:2966999..2966469,W3110:2967633..2967103 DNA display] [http://ecoliwiki.net/tools/display_protein.php?f=NC_000913&start=2967633&end=2967103&gene=rppH&aa=midddgyrpnvgivicnrqgqvmwarrfgqhswqfpqgginpgesaeqamyrelfeevglsrkdvrilastrnwlryklpkrlvrwdtkpvcigqkqkwfllqlvsgdaeinmqtsstpefdgwrwvsywypvrqvvsfkrdvyrrvmkefasvvmslqentpkpqnasayrrkrg Protein display] [http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Search&Term=rppH+AND+escherichia+coli Pubmed(rppH)] [http://trimer.tamu.edu/cgi-bin/textpresso/2.1/ecoli/search?searchstring=rppH Textpresso(rppH)] | |||
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Revision as of 23:35, 21 January 2010
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| Quickview | Gene | Gene Product(s) | Expression | Evolution | On One Page |
| References | Suggestions |
See Help:Quickview for help with entering information in the Quickview table.
| Standard Name |
rppH [1] |
|---|---|
| Gene Synonym(s) |
nudH, ECK2826, b2830, JW2798, ydgP, ygdP[2] |
| Product Desc. |
RNA pyrophosphohydrolase (removes the 5'-pyrophosphate from mRNAs and initiates degradation by the 5'-end dependent pathway)[1]; putative invasion protein[3][4] RNA pyrophosphohydrolase, destabilizes primary transcripts[5] |
| Product Synonyms(s) |
NudH,nucleotide hydrolase[2], B2830[3][2], NudH[3][2], YgdP[3][2] |
| Function from GO |
Biological Process
Molecular Function
|
| Knock-Out Phenotype |
Many mRNAs have an increased half-life. [1] |
| Regulation/Expression | |
| Regulation/Activity | |
| Quick Links | |
| edit table |
See Help:Quickview for help with entering information in the Quickview table.
Notes
Nudix hydrolase. RppH removes 5' triphosphate from primary transcripts, enhancing RNase E activity (Deana, 2008). Required for invasion of cultured mammalian cells by both E. coli K1 and S. typhimurium. NudH also hydrolyzes Ap5A and Ap4A. Ribosome-associated protein (Jiang, 2007).[5]
References
- ↑ 1.0 1.1 1.2 Deana, A et al. (2008) The bacterial enzyme RppH triggers messenger RNA degradation by 5' pyrophosphate removal. Nature 451 355-8 PubMed
- ↑ 2.0 2.1 2.2 2.3 2.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
- ↑ 3.0 3.1 3.2 3.3 3.4 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ 5.0 5.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.