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!align=left |Standard Name
!align=left {{table_heading_style}} |Standard Name
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''tonB''  
''tonB''  
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!align=left |Gene Synonym(s)
!align=left {{table_heading_style}} |Gene Synonym(s)
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''ECK1246, b1252, JW5195, T1rec, exbA''<ref name='LIB:Riley_2006'/>
''ECK1246, b1252, JW5195, T1rec, exbA''<ref name='LIB:Riley_2006'/>
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!align=left |Product Desc.
!align=left {{table_heading_style}} |Product Desc.
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TonB protein; energy transducer; uptake of iron, cyanocobalimin; sensitivity to phages, colicins<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>;  
TonB protein; energy transducer; uptake of iron, cyanocobalimin; sensitivity to phages, colicins<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>;  
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Uptake of chelated Fe(2+) and cyanocobalamin; works in conjunction with OM receptors; energy transducer; sensitivity to T1, phi80, and colicins; forms a complex with ExbB and ExbD<ref name='LIB:EcoGene'/>
Uptake of chelated Fe(2+) and cyanocobalamin; works in conjunction with OM receptors; energy transducer; sensitivity to T1, phi80, and colicins; forms a complex with ExbB and ExbD<ref name='LIB:EcoGene'/>
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!align=left |Product Synonyms(s)
!align=left {{table_heading_style}} |Product Synonyms(s)
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membrane spanning protein in TonB-ExbB-ExbD complex<ref name='LIB:Riley_2006'/>, B1252<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, ExbA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, TonB<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>  
membrane spanning protein in TonB-ExbB-ExbD complex<ref name='LIB:Riley_2006'/>, B1252<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, ExbA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, TonB<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>  
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!align=left |Knock-Out Phenotype
!align=left {{table_heading_style}} |Function from GO
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'''Biological Process'''
* GO:0015889 cobalamin transport ([http://www.geneontology.org/GO.evidence.shtml IGI])


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!align=left |Regulation/Expression
!align=left {{table_heading_style}} |Knock-Out Phenotype
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!align=left {{table_heading_style}} |Regulation/Expression
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transcription unit(s): [[:Category:Txn_unit:tonB|tonB]]<ref name='LIB:EcoCyc10.6'/>, OP00228  
transcription unit(s): [[:Category:Txn_unit:tonB|tonB]]<ref name='LIB:EcoCyc10.6'/>, OP00228  
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!align=left |Regulation/Activity
!align=left {{table_heading_style}} |Regulation/Activity
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!align=left {{table_heading_style}} |Quick Links
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[http://ecoliwiki.net/tools/display_dna.php?gene=tonB&loc=MG1655:1309113..1309832,W3110:1312803..1313522,DH10B:1398509..1399228,REL606:1308683..1309402 DNA display]&nbsp;&nbsp;&nbsp; [http://ecoliwiki.net/tools/display_protein.php?f=NC_000913&start=1308683&end=1309402&gene=tonB&aa=mtldlprrfpwptllsvcihgavvagllytsvhqvielpapaqpisvtmvtpadleppqavqpppepvvepepepepipeppkeapvviekpkpkpkpkpkpvkkvqeqpkrdvkpvesrpaspfentaparltsstataatskpvtsvasgpralsrnqpqyparaqalriegqvkvkfdvtpdgrvdnvqilsakpanmferevknamrrwryepgkpgsgivvnilfkingtteiq Protein display]&nbsp;&nbsp;&nbsp; [http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Search&Term=tonB+AND+escherichia+coli Pubmed(tonB)]&nbsp;&nbsp;&nbsp; [http://trimer.tamu.edu/cgi-bin/textpresso/2.1/ecoli/search?searchstring=tonB Textpresso(tonB)]


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Revision as of 23:28, 21 January 2010

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
References Suggestions

See Help:Quickview for help with entering information in the Quickview table.

Standard Name

tonB

Gene Synonym(s)

ECK1246, b1252, JW5195, T1rec, exbA[1]

Product Desc.

TonB protein; energy transducer; uptake of iron, cyanocobalimin; sensitivity to phages, colicins[2][3];

Component of TonB energy transducing system[3]; Outer Membrane Ferric Citrate Transport System[3]; Outer Membrane Ferrichrome Transport System[3]; Outer Membrane Ferric Enterobactin Transport System[3]; vitamin B12 outer membrane transport complex[3]; ferric dicitrate uptake system[3]; ferrichrome uptake system[3]; Ferric Enterobactin Transport System[3]; vitamin B12 transport system[3]

Uptake of chelated Fe(2+) and cyanocobalamin; works in conjunction with OM receptors; energy transducer; sensitivity to T1, phi80, and colicins; forms a complex with ExbB and ExbD[4]

Product Synonyms(s)

membrane spanning protein in TonB-ExbB-ExbD complex[1], B1252[2][1], ExbA[2][1], TonB[2][1]

Function from GO

Biological Process

Knock-Out Phenotype
Regulation/Expression

transcription unit(s): tonB[2], OP00228

Regulation/Activity
Quick Links

DNA display    Protein display    Pubmed(tonB)    Textpresso(tonB)

edit table

See Help:Quickview for help with entering information in the Quickview table.

Notes

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Periplasmic TonB is anchored to the cytoplasmic membrane by a signal anchor and interacts with outer membrane proteins, thus TonB spans the periplasmic space. TonB contains 40 proline residues (17%).[4]



References

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  1. ↑ 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.00 3.01 3.02 3.03 3.04 3.05 3.06 3.07 3.08 3.09 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
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