nrdA:Quickview: Difference between revisions

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!align=left |Standard Name
!align=left {{table_heading_style}} |Standard Name
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''nrdA''  
''nrdA''  
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!align=left |Gene Synonym(s)
!align=left {{table_heading_style}} |Gene Synonym(s)
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''ECK2226, b2234, JW2228, dnaF''<ref name='LIB:Riley_2006'/>
''ECK2226, b2234, JW2228, dnaF''<ref name='LIB:Riley_2006'/>
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!align=left |Product Desc.
!align=left {{table_heading_style}} |Product Desc.
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NrdA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>;  
NrdA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>;  
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Ribonucleoside diphosphate reductase, subunit alpha; class I, aerobic; ribonucleotide reductase; B1 protein, R1 subunit<ref name='LIB:EcoGene'/>
Ribonucleoside diphosphate reductase, subunit alpha; class I, aerobic; ribonucleotide reductase; B1 protein, R1 subunit<ref name='LIB:EcoGene'/>
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!align=left |Product Synonyms(s)
!align=left {{table_heading_style}} |Product Synonyms(s)
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ribonucleoside diphosphate reductase 1, alpha subunit<ref name='LIB:Riley_2006'/>, B2234<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, DnaF<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, NrdA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>  
ribonucleoside diphosphate reductase 1, alpha subunit<ref name='LIB:Riley_2006'/>, B2234<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, DnaF<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, NrdA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>  
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!align=left |Knock-Out Phenotype
!align=left {{table_heading_style}} |Function from GO
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'''Molecular Function'''
* GO:0005515 protein binding ([http://www.geneontology.org/GO.evidence.shtml IPI])
* GO:0005524 ATP binding ([http://www.geneontology.org/GO.evidence.shtml IDA])
* GO:0016959 class I ribonucleotide reductase activity ([http://www.geneontology.org/GO.evidence.shtml IDA])
* GO:0000166 nucleotide binding ([http://www.geneontology.org/GO.evidence.shtml IDA])
'''Biological Process'''
* GO:0009263 deoxyribonucleotide biosynthetic process ([http://www.geneontology.org/GO.evidence.shtml IDA])
* GO:0015949 nucleobase, nucleoside and nucleotide interconversion ([http://www.geneontology.org/GO.evidence.shtml IDA])
'''Cellular Component'''
* GO:0005737 cytoplasm ([http://www.geneontology.org/GO.evidence.shtml IDA])
* GO:0005971 ribonucleoside-diphosphate reductase complex ([http://www.geneontology.org/GO.evidence.shtml IDA])


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!align=left |Regulation/Expression
!align=left {{table_heading_style}} |Knock-Out Phenotype
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!align=left {{table_heading_style}} |Regulation/Expression
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transcription unit(s): [[:Category:Txn_unit:nrdAB|nrdAB]]<ref name='LIB:EcoCyc10.6'/>, OP00063, nrd, nrdA  
transcription unit(s): [[:Category:Txn_unit:nrdAB|nrdAB]]<ref name='LIB:EcoCyc10.6'/>, OP00063, nrd, nrdA  
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!align=left |Regulation/Activity
!align=left {{table_heading_style}} |Regulation/Activity
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!align=left {{table_heading_style}} |Quick Links
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[http://ecoliwiki.net/tools/display_dna.php?gene=nrdA&loc=MG1655:2342887..2345172,W3110:2349535..2351820,DH10B:2433875..2436160,REL606:2291565..2293850 DNA display]&nbsp;&nbsp;&nbsp; [http://ecoliwiki.net/tools/display_protein.php?f=NC_000913&start=2291565&end=2293850&gene=nrdA&aa=mnqnllvtkrdgsterinldkihrvldwaaeglhnvsisqvelrshiqfydgiktsdihetiikaaadlisrdapdyqylaarlaifhlrkkaygqfeppalydhvvkmvemgkydnhlledyteeefkqmdtfidhdrdmtfsyaavkqlegkylvqnrvtgeiyesaqflyilvaaclfsnypretrlqyvkrfydavstfkislptpimsgvrtptrqfsscvliecgdsldsinatssaivkyvsqragiginagriralgspirggeafhtgcipfykhfqtavkscsqggvrggaatlfypmwhlevesllvlknnrgvegnrvrhmdygvqinklmytrllkgeditlfspsdvpglydaffadqeeferlytkyekddsirkqrvkavelfslmmqerastgriyiqnvdhcnthspfdpaiapvrqsnlcleialptkplndvndengeialctlsafnlgainnldeleelailavraldalldyqdypipaakrgamgrrtlgigvinfayylakhgkrysdgsannlthktfeaiqyyllkasnelakeqgacpwfnettyakgilpidtykkdldtianeplhydwealresikthglrnstlsalmpsetssqisnatngiepprgyvsikaskdgilrqvvpdyehlhdayellwempgndgylqlvgimqkfidqsisantnydpsrfpsgkvpmqqllkdlltaykfgvktlyyqntrdgaedaqddlvpsiqddgcesgacki Protein display]&nbsp;&nbsp;&nbsp; [http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Search&Term=nrdA+AND+escherichia+coli Pubmed(nrdA)]&nbsp;&nbsp;&nbsp; [http://trimer.tamu.edu/cgi-bin/textpresso/2.1/ecoli/search?searchstring=nrdA Textpresso(nrdA)]


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Revision as of 23:39, 21 January 2010

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
References Suggestions

See Help:Quickview for help with entering information in the Quickview table.

Standard Name

nrdA

Gene Synonym(s)

ECK2226, b2234, JW2228, dnaF[1]

Product Desc.

NrdA[2][3];

Component of B1 protein[2][3]; ribonucleotide reductase I[2]

Ribonucleoside diphosphate reductase, subunit alpha; class I, aerobic; ribonucleotide reductase; B1 protein, R1 subunit[4]

Product Synonyms(s)

ribonucleoside diphosphate reductase 1, alpha subunit[1], B2234[2][1], DnaF[2][1], NrdA[2][1]

Function from GO

Molecular Function

Biological Process

Cellular Component

Knock-Out Phenotype
Regulation/Expression

transcription unit(s): nrdAB[2], OP00063, nrd, nrdA

Regulation/Activity
Quick Links

DNA display    Protein display    Pubmed(nrdA)    Textpresso(nrdA)

edit table

See Help:Quickview for help with entering information in the Quickview table.

Notes

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Reducing equivalents provided by glutaredoxin or thioredoxin. Binds TrxA (Kumar, 2004). About half of the overproduced protein has the first one or two amino acids removed. E. coli B native protein is reported to start with Gln. a second native E. coli B protein start may correspond to a cleavage after Leu26. Leu26 CTG codon is unlikely to be an alternative start codon in K-12 or B and no evidence of this cleavage or an alternative start codon was seen with the overproduced K-12 protein. An M-N or MN-Q cleavage by MAP would be unusual. The variable N-termini may be created by an unknown protease.[4]



References

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  1. ↑ 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
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