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!align=left |Standard Name
!align=left {{table_heading_style}} |Standard Name
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''maeA''  
''maeA''  
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!align=left |Gene Synonym(s)
!align=left {{table_heading_style}} |Gene Synonym(s)
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''sfcA, ECK1473, b1479, JW5238, mae, maeA?''<ref name='LIB:Riley_2006'/><ref name='LIB:EcoCyc11.1'/><ref name='LIB:EcoCyc10.6'/>
''sfcA, ECK1473, b1479, JW5238, mae, maeA?''<ref name='LIB:Riley_2006'/><ref name='LIB:EcoCyc11.1'/><ref name='LIB:EcoCyc10.6'/>
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!align=left |Product Desc.
!align=left {{table_heading_style}} |Product Desc.
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MaeA<ref name='LIB:EcoCyc10.6'/>; malate dehydrogenase, NAD-requiring<ref name='LIB:EcoCyc11.1'/>;  
MaeA<ref name='LIB:EcoCyc10.6'/>; malate dehydrogenase, NAD-requiring<ref name='LIB:EcoCyc11.1'/>;  
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Malic enzyme, NAD-dependent; NAD-ME<ref name='LIB:EcoGene'/>
Malic enzyme, NAD-dependent; NAD-ME<ref name='LIB:EcoGene'/>
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!align=left |Product Synonyms(s)
!align=left {{table_heading_style}} |Product Synonyms(s)
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malate dehydrogenase, (decarboxylating, NAD-requiring) (malic enzyme)<ref name='LIB:Riley_2006'/>, B1479<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, MaeA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, SfcA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>  
malate dehydrogenase, (decarboxylating, NAD-requiring) (malic enzyme)<ref name='LIB:Riley_2006'/>, B1479<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, MaeA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, SfcA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>  
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!align=left |Knock-Out Phenotype
!align=left {{table_heading_style}} |Function from GO
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'''Biological Process'''
* GO:0006094 gluconeogenesis ([http://www.geneontology.org/GO.evidence.shtml IMP])
'''Molecular Function'''
* GO:0016619 malate dehydrogenase (oxaloacetate-decarboxylating) activity ([http://www.geneontology.org/GO.evidence.shtml IDA])


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!align=left |Regulation/Expression
!align=left {{table_heading_style}} |Knock-Out Phenotype
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!align=left {{table_heading_style}} |Regulation/Expression
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transcription unit(s): [[:Category:Txn_unit:sfcA|sfcA]]<ref name='LIB:EcoCyc10.6'/>  
transcription unit(s): [[:Category:Txn_unit:sfcA|sfcA]]<ref name='LIB:EcoCyc10.6'/>  
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!align=left |Regulation/Activity
!align=left {{table_heading_style}} |Regulation/Activity
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!align=left {{table_heading_style}} |Quick Links
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[http://ecoliwiki.net/tools/display_dna.php?gene=maeA&loc=MG1655:1553693..1551996,W3110:1557383..1555686,DH10B:1644288..1642591,REL606:1527910..1529607 DNA display]&nbsp;&nbsp;&nbsp; [http://ecoliwiki.net/tools/display_protein.php?f=NC_000913&start=1527910&end=1529607&gene=maeA&aa=mdiqkrvsdmepktkkqrslyipyagpvllefpllnkgsafsmeerrnfnllgllpevvetieeqaerawiqyqgfkteidkhiylrniqdtnetlfyrlvnnhldemmpviytptvgaacerfseiyrrsrgvfisyqnrhnmddilqnvpnhnikvivvtdgerilglgdqgiggmgipigklslytacggispaytlpvvldvgtnnqqllndplymgwrnpritddeyyefvdefiqavkqrwpdvllqfedfaqknampllnryrneicsfnddiqgtaavtvgtliaasraaggqlsekkivflgagsagcgiaemiisqtqreglseeaarqkvfmvdrfglltdkmpnllpfqtklvqkrenlsdwdtdsdvlslldvvrnvkpdiligvsgqtglfteeiiremhkhcprpivmplsnptsrveatpqdiiawtegnalvatgspfnpvvwkdkiypiaqcnnafifpgiglgviasgasritdemlmsasetlaqysplvlngegmvlpelkdiqkvsraiafavgkmaqqqgvavktsaealqqaiddnfwqaeyrdyrrtsi Protein display]&nbsp;&nbsp;&nbsp; [http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Search&Term=maeA+AND+escherichia+coli Pubmed(maeA)]&nbsp;&nbsp;&nbsp; [http://trimer.tamu.edu/cgi-bin/textpresso/2.1/ecoli/search?searchstring=maeA Textpresso(maeA)]


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Revision as of 23:45, 21 January 2010

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
References Suggestions

See Help:Quickview for help with entering information in the Quickview table.

Standard Name

maeA

Gene Synonym(s)

sfcA, ECK1473, b1479, JW5238, mae, maeA?[1][2][3]

Product Desc.

MaeA[3]; malate dehydrogenase, NAD-requiring[2];

Component of malic enzyme, NAD-linked[3]; malate dehydrogenase, NAD-requiring[2]

Malic enzyme, NAD-dependent; NAD-ME[4]

Product Synonyms(s)

malate dehydrogenase, (decarboxylating, NAD-requiring) (malic enzyme)[1], B1479[3][1], MaeA[3][1], SfcA[3][1]

Function from GO

Biological Process

Molecular Function

  • GO:0016619 malate dehydrogenase (oxaloacetate-decarboxylating) activity (IDA)
Knock-Out Phenotype
Regulation/Expression

transcription unit(s): sfcA[3]

Regulation/Activity
Quick Links

DNA display    Protein display    Pubmed(maeA)    Textpresso(maeA)

edit table

See Help:Quickview for help with entering information in the Quickview table.

Notes

[back to top]


MaeA catalyzes four reactions: I, NAD-dependent L-malate decarboxylation; II, NAD-independent oxalacetate decarboxylation; III, oxalacetate reductase, NAD-dependent; !V, pyruvate reductase, NAD-dependent. Acetyl-CoA and ATP are allosteric inhibitors; aspartate is an allosteric activator. Reaction I proceeds by two steps: dehydrogenation, then decarboxylation.[4]



References

[back to top]


  1. ↑ 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
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