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!align=left |Standard Name
!align=left {{table_heading_style}} |Standard Name
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''hipA''  
''hipA''  
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!align=left |Gene Synonym(s)
!align=left {{table_heading_style}} |Gene Synonym(s)
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''ECK1500, b1507, JW1500''<ref name='LIB:Riley_2006'/>
''ECK1500, b1507, JW1500''<ref name='LIB:Riley_2006'/>
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!align=left |Product Desc.
!align=left {{table_heading_style}} |Product Desc.
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HipA Polypeptide<ref name='LIB:EcoCyc10.6'/>; serine kinase HipA<ref name='LIB:EcoCyc11.1'/>;  
HipA Polypeptide<ref name='LIB:EcoCyc10.6'/>; serine kinase HipA<ref name='LIB:EcoCyc11.1'/>;  
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Toxin, growth inhibition blocked by continuous HipB synthesis;; probable role in cell division<ref name='LIB:EcoGene'/>
Toxin, growth inhibition blocked by continuous HipB synthesis;; probable role in cell division<ref name='LIB:EcoGene'/>
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!align=left |Product Synonyms(s)
!align=left {{table_heading_style}} |Product Synonyms(s)
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regulator with hipB<ref name='LIB:Riley_2006'/>, B1507<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, HipA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>  
regulator with hipB<ref name='LIB:Riley_2006'/>, B1507<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, HipA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>  
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!align=left |Knock-Out Phenotype
!align=left {{table_heading_style}} |Function from GO
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'''Biological Process'''
* GO:0006350 transcription ([http://www.geneontology.org/GO.evidence.shtml IDA])
'''Molecular Function'''
* GO:0016564 transcription repressor activity ([http://www.geneontology.org/GO.evidence.shtml IDA])
* GO:0005515 protein binding ([http://www.geneontology.org/GO.evidence.shtml IPI])
* GO:0004674 protein serine/threonine kinase activity ([http://www.geneontology.org/GO.evidence.shtml IDA])


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!align=left |Regulation/Expression
!align=left {{table_heading_style}} |Knock-Out Phenotype
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!align=left {{table_heading_style}} |Regulation/Expression
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transcription unit(s): [[:Category:Txn_unit:hipBA|hipBA]]<ref name='LIB:EcoCyc10.6'/>  
transcription unit(s): [[:Category:Txn_unit:hipBA|hipBA]]<ref name='LIB:EcoCyc10.6'/>  
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!align=left |Regulation/Activity
!align=left {{table_heading_style}} |Regulation/Activity
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!align=left {{table_heading_style}} |Quick Links
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[http://ecoliwiki.net/tools/display_dna.php?gene=hipA&loc=MG1655:1590200..1588878,W3110:1593890..1592568,DH10B:1679825..1678503,REL606:1568743..1567421 DNA display]&nbsp;&nbsp;&nbsp; [http://ecoliwiki.net/tools/display_protein.php?f=NC_000913&start=1568743&end=1567421&gene=hipA&aa=mpklvtwmnnqrvgeltklangahtfkyapewlasryarplslslplqrgnitsdavfnffdnllpdspivrdrivkryhaksrqpfdllseigrdsvgavtlipedetvthpimawekltearleevltaykadiplgmireendfrisvagaqektallrigndwcipkgitptthiiklpigeirqpnatldlsqsvdneyyclllakelglnvpdaeiikagnvralaverfdrrwnaertvllrlpqedmcqtfglpssvkyesdggpgiarimaflmgssealkdrydfmkfqvfqwligatdghaknfsvfiqaggsyrltpfydiisafpvlggtgihisdlklamglnaskgkktaidkiyprhflatakvlrfpevqmheilsdfarmipaaldnvktslptdfpenvvtavesnvlrlhgrlsreygsk Protein display]&nbsp;&nbsp;&nbsp; [http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Search&Term=hipA+AND+escherichia+coli Pubmed(hipA)]&nbsp;&nbsp;&nbsp; [http://trimer.tamu.edu/cgi-bin/textpresso/2.1/ecoli/search?searchstring=hipA Textpresso(hipA)]


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Revision as of 23:52, 21 January 2010

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
References Suggestions

See Help:Quickview for help with entering information in the Quickview table.

Standard Name

hipA

Gene Synonym(s)

ECK1500, b1507, JW1500[1]

Product Desc.

HipA Polypeptide[2]; serine kinase HipA[3];

Component of HipB transcriptional repressor[3]

Toxin, growth inhibition blocked by continuous HipB synthesis;; probable role in cell division[4]

Product Synonyms(s)

regulator with hipB[1], B1507[2][1], HipA[2][1]

Function from GO

Biological Process

Molecular Function

Knock-Out Phenotype
Regulation/Expression

transcription unit(s): hipBA[2]

Regulation/Activity
Quick Links

DNA display    Protein display    Pubmed(hipA)    Textpresso(hipA)

edit table

See Help:Quickview for help with entering information in the Quickview table.

Notes

[back to top]


HipA serine protein kinase autophosphorylates Ser150 and this activity is essential for persister formation (Correia, 2006). HipA binds and phosphorylates TufA/TufB (Schumacher, 2009).[4]



References

[back to top]


  1. ↑ 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
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