mdlA:Gene Product(s): Difference between revisions

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Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
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complete
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GO:0000166
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nucleotide binding
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GO_REF:0000002<br />GO_REF:0000004
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IEA: Inferred from Electronic Annotation
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InterPro:IPR003593<br />SP_KW:KW-0547
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F
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Seeded from EcoCyc
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complete
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GO:0005524
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ATP binding
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GO_REF:0000002<br />GO_REF:0000002<br />GO_REF:0000002<br />GO_REF:0000002<br />GO_REF:0000004
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IEA: Inferred from Electronic Annotation
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InterPro:IPR001140<br />InterPro:IPR003439<br />InterPro:IPR011527<br />InterPro:IPR017871<br />SP_KW:KW-0067
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F
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Seeded from EcoCyc
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complete
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GO:0005886
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plasma membrane
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GO_REF:0000004<br />GO_REF:0000004<br />GO_REF:0000023
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IEA: Inferred from Electronic Annotation
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SP_KW:KW-0997<br />SP_KW:KW-1003<br />SP_SL:SL-0037
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C
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Seeded from EcoCyc
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complete
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GO:0006810
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transport
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GO_REF:0000002<br />GO_REF:0000002<br />GO_REF:0000004
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IEA: Inferred from Electronic Annotation
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InterPro:IPR001140<br />InterPro:IPR011527<br />SP_KW:KW-0813
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P
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Seeded from EcoCyc
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complete
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GO:0008559
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xenobiotic-transporting ATPase activity
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GO_REF:0000003
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IEA: Inferred from Electronic Annotation
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EC:3.6.3.44
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F
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Seeded from EcoCyc
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complete
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GO:0016020
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membrane
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GO_REF:0000004
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IEA: Inferred from Electronic Annotation
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SP_KW:KW-0472
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C
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Seeded from EcoCyc
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complete
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GO:0016021
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integral to membrane
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GO_REF:0000002<br />GO_REF:0000002<br />GO_REF:0000004
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IEA: Inferred from Electronic Annotation
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InterPro:IPR001140<br />InterPro:IPR011527<br />SP_KW:KW-0812
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C
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Seeded from EcoCyc
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complete
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GO:0016787
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hydrolase activity
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GO_REF:0000004
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IEA: Inferred from Electronic Annotation
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SP_KW:KW-0378
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F
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Seeded from EcoCyc
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complete
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GO:0016887
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ATPase activity
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GO_REF:0000002<br />GO_REF:0000002
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IEA: Inferred from Electronic Annotation
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InterPro:IPR003439<br />InterPro:IPR017871
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F
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Seeded from EcoCyc
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complete
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GO:0017111
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nucleoside-triphosphatase activity
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GO_REF:0000002
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IEA: Inferred from Electronic Annotation
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InterPro:IPR003593
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F
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Seeded from EcoCyc
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complete
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GO:0042626
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ATPase activity, coupled to transmembrane movement of substances
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GO_REF:0000002<br />GO_REF:0000002
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IEA: Inferred from Electronic Annotation
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InterPro:IPR001140<br />InterPro:IPR011527
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F
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Seeded from EcoCyc
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complete  
complete  

Revision as of 16:56, 5 October 2009

{{#css:Suppresslinks.css}}<css>h1 .editsection { display:none;} h2 .editsection { display:none;}</css>

Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

MdlA

Synonyms

fused predicted multidrug transporter subunits of ABC superfamily: ATP-binding components[1], B0448[2][1], Mdl[2][1], MdlA[2][1]

Product description

predicted multidrug transporter subunit of ABC superfamily: ATP-binding component[2][3]

Multidrug resistance-like protein, ABC family; no overexpression resistances found[4]

EC number (for enzymes)


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Notes

Function

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Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference(s) Evidence Code with/from Aspect Notes Status
GO:0000166

nucleotide binding

GO_REF:0000002
GO_REF:0000004

IEA: Inferred from Electronic Annotation

InterPro:IPR003593
SP_KW:KW-0547

F

Seeded from EcoCyc [5]

complete

GO:0005524

ATP binding

GO_REF:0000002
GO_REF:0000002
GO_REF:0000002
GO_REF:0000004

IEA: Inferred from Electronic Annotation

InterPro:IPR001140
InterPro:IPR003439
InterPro:IPR011527
SP_KW:KW-0067

F

Seeded from EcoCyc 12.5 [6]

complete

GO:0006810

transport

GO_REF:0000002
GO_REF:0000002
GO_REF:0000004

IEA: Inferred from Electronic Annotation

InterPro:IPR001140
InterPro:IPR011527
SP_KW:KW-0813

P

Seeded from EcoCyc [5]

complete

GO:0008559

xenobiotic-transporting ATPase activity

GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:3.6.3.44

F

Seeded from EcoCyc [5]

complete

GO:0016020

membrane

GO_REF:0000004
GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0397
SP_KW:KW-0472

C

Seeded from EcoCyc 12.5 [6]

complete

GO:0016021

integral to membrane

GO_REF:0000002
GO_REF:0000002
GO_REF:0000004

IEA: Inferred from Electronic Annotation

InterPro:IPR001140
InterPro:IPR011527
SP_KW:KW-0812

C

Seeded from EcoCyc [5]

complete

GO:0016787

hydrolase activity

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0378

F

Seeded from EcoCyc [5]

complete

GO:0016887

ATPase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003439

F

Seeded from EcoCyc 12.5 [6]

complete

GO:0017111

nucleoside-triphosphatase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003593

F

Seeded from EcoCyc [5]

complete

GO:0042626

ATPase activity, coupled to transmembrane movement of substances

GO_REF:0000002
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001140
InterPro:IPR011527

F

Seeded from EcoCyc [5]

complete

GO:0042493

response to drug

P

Seeded from EcoCyc 11.1[3].

required fields missing

GO:0005886

plasma membrane

GO_REF:0000004
GO_REF:0000004
GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_KW:KW-0997
SP_KW:KW-1003
SP_SL:SL-0037

C

Seeded from EcoCyc [5]

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence
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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Notes

plasma membrane

C-terminus localized in the cytoplasm with 6 predicted transmembrane domains

Daley et al. (2005) [7]


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Notes

Structure and Physical Properties

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Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Sequence

at EcoCyc 

MRLFAQLSWY FRREWRRYLG AVALLVIIAM LQLVPPKVVG IVVDGVTEQH FTTGQILMWI
ATMVLIAVVV YLLRYVWRVL LFGASYQLAV ELREDYYRQL SRQHPEFYLR HRTGDLMARA
TNDVDRVVFA AGEGVLTLVD SLVMGCAVLI MMSTQISWQL TLFSLLPMPV MAIMIKRNGD
ALHERFKLAQ AAFSSLNDRT QESLTSIRMI KAFGLEDRQS ALFAADAEDT GKKNMRVARI
DARFDPTIYI AIGMANLLAI GGGSWMVVQG SLTLGQLTSF MMYLGLMIWP MLALAWMFNI
VERGSAAYSR IRAMLAEAPV VNDGSEPVPE GRGELDVNIH QFTYPQTDHP ALENVNFALK
PGQMLGICGP TGSGKSTLLS LIQRHFDVSE GDIRFHDIPL TKLQLDSWRS RLAVVSQTPF
LFSDTVANNI ALGCPNATQQ EIEHVARLAS VHDDILRLPQ GYDTEVGERG VMLSGGQKQR
ISIARALLVN AEILILDDAL SAVDGRTEHQ ILHNLRQWGQ GRTVIISAHR LSALTEASEI
IVMQHGHIAQ RGNHDVLAQQ SGWYRDMYRY QQLEAALDDA PENREEAVDA
Length

590

Mol. Wt

66.018 kDa

pI

6.5 (calculated)

Extinction coefficient

84,340 - 84,715 (calc based on 16 Y, 11 W, and 3 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes
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<motif_map/>

tmhmm.php?gene=mdlA&show=pic&.jpg
Click the image to view raw output from TMHMM.

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=mdlA taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

EcoCyc (EcoliWiki Page)

EcoCyc:MDLA-MONOMER

UniProt (EcoliWiki Page)

UniProt:P77265

PFAM (EcoliWiki Page)

PFAM:PF00664

RefSeq (EcoliWiki Page)

RefSeq:NP_414982

ModBase (EcoliWiki Page)

ModBase:P77265


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Notes

Links

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Name URL Comments
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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ 5.0 5.1 5.2 5.3 5.4 5.5 5.6 5.7 EcoCyc (release 13.0; 2009) Keseler, IM et al. (2009) Nucleic Acids Res. 37(Database issue):D464-70
  6. ↑ 6.0 6.1 6.2 EcoCyc (release 12.5; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  7. ↑ Daley, DO et al. (2005) Global topology analysis of the Escherichia coli inner membrane proteome. Science 308 1321-3 PubMed

Categories

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