adiC:Gene Product(s): Difference between revisions

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P
P
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Seeded from EcoCyc
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complete
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GO:0015171
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amino acid transmembrane transporter activity
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GO_REF:0000002
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IEA: Inferred from Electronic Annotation
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InterPro:IPR002293
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F
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Seeded from EcoCyc
Seeded from EcoCyc
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GO:0015171
GO:0015297
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amino acid transmembrane transporter activity
antiporter activity
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GO_REF:0000002
GO_REF:0000004
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IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
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InterPro:IPR002293
SP_KW:KW-0050
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F
F

Revision as of 21:47, 21 May 2009

{{#css:Suppresslinks.css}}<css>h1 .editsection { display:none;} h2 .editsection { display:none;}</css>

Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

AdiC product

Synonyms

arginine:agmatin product[1], B4115 product[2][1], YjdD product[2][1], YjdE product[2][1], AdiC product[2][1]

Product description

AdiC Arginine:Agmatine Antiporter[2]; AdiC[3];

Component of AdiC arginine:agmatine antiporter[3]

Arginine:agmatine antiporter; arginine-dependent acid resistance; acid-inducible membrane protein[4]

EC number (for enzymes)


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Notes

Function

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Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference(s) Evidence Code with/from Aspect Notes Status
GO:0001101

response to acid

PMID:12867448[5]

IMP: Inferred from Mutant Phenotype

P

Seeded from EcoCyc [6]

complete

GO:0016021

integral to membrane

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0812

C

Seeded from EcoCyc [6]

complete

GO:0016020

membrane

GO_REF:0000002
GO_REF:0000002
GO_REF:0000004
GO_REF:0000004

IEA: Inferred from Electronic Annotation

InterPro:IPR002293
InterPro:IPR004841
SP_KW:KW-0397
SP_KW:KW-0472

C

Seeded from EcoCyc 12.5 [7]

complete

GO:0015171

amino acid transmembrane transporter activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002293

F

Seeded from EcoCyc [6]

complete

GO:0006865

amino acid transport

GO_REF:0000002
GO_REF:0000004

IEA: Inferred from Electronic Annotation

InterPro:IPR002293
SP_KW:KW-0029

P

Seeded from EcoCyc [6]

complete

GO:0006810

transport

GO_REF:0000002
GO_REF:0000004

IEA: Inferred from Electronic Annotation

InterPro:IPR004841
SP_KW:KW-0813

P

Seeded from EcoCyc [6]

complete

GO:0015300

solute:solute antiporter activity

PMID:17099215[8]

IDA: Inferred from Direct Assay

F

Seeded from EcoCyc [6]

complete

GO:0051454

intracellular pH elevation

PMID:12867448[5]

IMP: Inferred from Mutant Phenotype

P

Seeded from EcoCyc [6]

complete

GO:0015292

uniporter activity

F

Seeded from EcoCyc 10.6[2].

required fields missing

GO:0005886

plasma membrane

GO_REF:0000004
GO_REF:0000004
GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_KW:KW-0997
SP_KW:KW-1003
SP_SL:SL-0037

C

Seeded from EcoCyc [6]

complete

GO:0015297

antiporter activity

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0050

F

Seeded from EcoCyc [6]

complete

GO:0001101

response to acid

PMID:12867448[5]

IMP: Inferred from Mutant Phenotype

P

Seeded from EcoCyc

complete

GO:0005886

plasma membrane

GO_REF:0000004
GO_REF:0000004
GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_KW:KW-0997
SP_KW:KW-1003
SP_SL:SL-0037

C

Seeded from EcoCyc

complete

GO:0006810

transport

GO_REF:0000002
GO_REF:0000004

IEA: Inferred from Electronic Annotation

InterPro:IPR004841
SP_KW:KW-0813

P

Seeded from EcoCyc

complete

GO:0006865

amino acid transport

GO_REF:0000002
GO_REF:0000004

IEA: Inferred from Electronic Annotation

InterPro:IPR002293
SP_KW:KW-0029

P

Seeded from EcoCyc

complete

GO:0015171

amino acid transmembrane transporter activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002293

F

Seeded from EcoCyc

complete

GO:0051454

intracellular pH elevation

PMID:12867448[5]

IMP: Inferred from Mutant Phenotype

P

Seeded from EcoCyc 11.1[3].

complete

GO:0015300

solute:solute antiporter activity

PMID:17099215[8]

IDA: Inferred from Direct Assay

F

Seeded from EcoCyc 11.1[3].

complete

GO:0015297

antiporter activity

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0050

F

Seeded from EcoCyc

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

Subunits of AdiC arginine:agmatine antiporter

could be indirect


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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Notes

plasma membrane

C-terminus localized in the cytoplasm with 11 predicted transmembrane domains

Daley et al. (2005) [9]

plasma membrane

From EcoCyc[3]

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Notes

Structure and Physical Properties

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Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Sequence

at EcoCyc 

MSSDADAHKV GLIPVTLMVS GNIMGSGVFL LPANLASTGG IAIYGWLVTI IGALGLSMVY
AKMSFLDPSP GGSYAYARRC FGPFLGYQTN VLYWLACWIG NIAMVVIGVG YLSYFFPILK
DPLVLTITCV VVLWIFVLLN IVGPKMITRV QAVATVLALI PIVGIAVFGW FWFRGETYMA
AWNVSGLGTF GAIQSTLNVT LWSFIGVESA SVAAGVVKNP KRNVPIATIG GVLIAAVCYV
LSTTAIMGMI PNAALRVSAS PFGDAARMAL GDTAGAIVSF CAAAGCLGSL GGWTLLAGQT
AKAAADDGLF PPIFARVNKA GTPVAGLIIV GILMTIFQLS SISPNATKEF GLVSSVSVIF
TLVPYLYTCA ALLLLGHGHF GKARPAYLAV TTIAFLYCIW AVVGSGAKEV MWSFVTLMVI
TAMYALNYNR LHKNPYPLDA PISKD
Length

445

Mol. Wt

46.84 kDa (calc) [2]

pI
Extinction coefficient

85830 - 86830 (calc based on 17 Y, 11 W, and 8 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes

Domain

10 - 32

Predicted membrane-spanning helix.

TMD predicted by TMHMM[10]

Domain

39 - 61

Predicted membrane-spanning helix.

TMD predicted by TMHMM[10]

Domain

94 - 116

Predicted membrane-spanning helix.

TMD predicted by TMHMM[10]

Domain

123 - 142

Predicted membrane-spanning helix.

TMD predicted by TMHMM[10]

Domain

152 - 171

Predicted membrane-spanning helix.

TMD predicted by TMHMM[10]

Domain

184 - 206

Predicted membrane-spanning helix.

TMD predicted by TMHMM[10]

Domain

226 - 248

Predicted membrane-spanning helix.

TMD predicted by TMHMM[10]

Domain

275 - 297

Predicted membrane-spanning helix.

TMD predicted by TMHMM[10]

Domain

320 - 342

Predicted membrane-spanning helix.

TMD predicted by TMHMM[10]

Domain

354 - 376

Predicted membrane-spanning helix.

TMD predicted by TMHMM[10]

Domain

386 - 403

Predicted membrane-spanning helix.

TMD predicted by TMHMM[10]

Domain

410 - 428

Predicted membrane-spanning helix.

TMD predicted by TMHMM[10]

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<motif_map/>

tmhmm.php?gene=adiC&show=pic&.jpg
Click the image to view raw output from TMHMM.

Structure See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure>adiC 562</beststructure>

Models

View models at:

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

EcoCyc (EcoliWiki Page)

EcoCyc:YJDE-MONOMER

UniProt (EcoliWiki Page)

UniProt:P60061

PFAM (EcoliWiki Page)

PFAM:PF00324

RefSeq (EcoliWiki Page)

RefSeq:NP_418539


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Notes

Links

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Name URL Comments
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References

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  1. ↑ 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 3.2 3.3 3.4 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ 5.0 5.1 5.2 5.3 Gong, S et al. (2003) YjdE (AdiC) is the arginine:agmatine antiporter essential for arginine-dependent acid resistance in Escherichia coli. J. Bacteriol. 185 4402-9 PubMed
  6. ↑ 6.0 6.1 6.2 6.3 6.4 6.5 6.6 6.7 6.8 EcoCyc (release 13.0; 2009) Keseler, IM et al. (2009) Nucleic Acids Res. 37(Database issue):D464-70
  7. ↑ EcoCyc (release 12.5; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  8. ↑ 8.0 8.1 Fang, Y et al. (2007) A bacterial arginine-agmatine exchange transporter involved in extreme acid resistance. J Biol Chem 282 176-82 PubMed
  9. ↑ Daley, DO et al. (2005) Global topology analysis of the Escherichia coli inner membrane proteome. Science 308 1321-3 PubMed
  10. ↑ 10.00 10.01 10.02 10.03 10.04 10.05 10.06 10.07 10.08 10.09 10.10 10.11 Krogh, A et al. (2001) Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes. J. Mol. Biol. 305 567-80 PubMed


Categories

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