add:Quickview: Difference between revisions

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!align=left {{table_heading_style}} |Standard Name
!align=left |Standard Name
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''add''  
''add''  
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!align=left {{table_heading_style}} |Gene Synonym(s)
!align=left |Gene Synonym(s)
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''ECK1618, b1623, JW1615''<ref name='LIB:Riley_2006'/>
''ECK1618, b1623, JW1615''<ref name='LIB:Riley_2006'/>
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!align=left {{table_heading_style}} |Product Desc.
!align=left |Product Desc.
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Adenosine deaminase; mutants affect growth on deoxyadenosine in purA, B mutants<ref name='LIB:EcoGene'/>
Adenosine deaminase; mutants affect growth on deoxyadenosine in purA, B mutants<ref name='LIB:EcoGene'/>
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!align=left {{table_heading_style}} |Product Synonyms(s)
!align=left |Product Synonyms(s)
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adenosine deaminase<ref name='LIB:Riley_2006'/>, B1623<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, Add<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>  
adenosine deaminase<ref name='LIB:Riley_2006'/>, B1623<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, Add<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>  
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!align=left {{table_heading_style}} |Knock-Out Phenotype
!align=left |Knock-Out Phenotype
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!align=left {{table_heading_style}} |Regulation/Expression
!align=left |Regulation/Expression
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transcription unit(s): [[:Category:Txn_unit:add|add]]<ref name='LIB:EcoCyc10.6'/>  
transcription unit(s): [[:Category:Txn_unit:add|add]]<ref name='LIB:EcoCyc10.6'/>  
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!align=left {{table_heading_style}} |Regulation/Activity
!align=left |Regulation/Activity
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Revision as of 23:54, 8 January 2010

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
References Suggestions

See Help:Quickview for help with entering information in the Quickview table.

Standard Name

add

Gene Synonym(s)

ECK1618, b1623, JW1615[1]

Product Desc.

Adenosine deaminase; mutants affect growth on deoxyadenosine in purA, B mutants[2]

Product Synonyms(s)

adenosine deaminase[1], B1623[3][1], Add[3][1]

Knock-Out Phenotype
Regulation/Expression

transcription unit(s): add[3]

Regulation/Activity


edit table

See Help:Quickview for help with entering information in the Quickview table.

Notes

[back to top]


Adenosine deaminase is an enzyme involved in purine metabolism, which irreversibly deaminates both adenosine and deoxyadenosine to inosine and deoxyinosine. The optimal pH for this enzyme is around 7.5-8, but activity is irreversibly lost when pH is lower than 2.7 or higher than 9.5. Adenosine deaminase is sensitive to heavy metals, such as Ag+, Cu2+, and Cr3+, and reacts with them irreversibly (Koch, 1958). [4]

Complications in purine metabolism often result in various disorders in humans. Deficiencies amounts of adenosine deaminase result in diseases such as severe combined immunodeficiency disorder (SCID) and lymphopenia.

Binds TrxA (Kumar, 2004).[2]



References

[back to top]


  1. ↑ 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  3. ↑ 3.0 3.1 3.2 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ KOCH, AL & VALLEE, G (1959) The properties of adenosine deaminase and adenosine nucleoside phosphorylase in extracts of Escherichia coli. J. Biol. Chem. 234 1213-8 PubMed


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