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!align=left {{table_heading_style}} |Standard Name
!align=left |Standard Name
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''acrA''  
''acrA''  
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!align=left {{table_heading_style}} |Gene Synonym(s)
!align=left |Gene Synonym(s)
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''ECK0457, b0463, JW0452, Mb, lir, mbl, mtcA, sipB, nbsA''<ref name='LIB:Riley_2006'/>
''ECK0457, b0463, JW0452, Mb, lir, mbl, mtcA, sipB, nbsA''<ref name='LIB:Riley_2006'/>
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!align=left {{table_heading_style}} |Product Desc.
!align=left |Product Desc.
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AcrA Membrane Fusion Protein<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>;  
AcrA Membrane Fusion Protein<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>;  
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AcrAB-TolC multidrug efflux pump; additionally dye, detergent, solvent resistance; membrane-fusion lipoprotein<ref name='LIB:EcoGene'/>
AcrAB-TolC multidrug efflux pump; additionally dye, detergent, solvent resistance; membrane-fusion lipoprotein<ref name='LIB:EcoGene'/>
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!align=left {{table_heading_style}} |Product Synonyms(s)
!align=left |Product Synonyms(s)
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multidrug efflux system<ref name='LIB:Riley_2006'/>, B0463<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, SipB<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, Mbl<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, Lir<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, NbsA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, MtcA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, AcrA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, acridine efflux pump<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>  
multidrug efflux system<ref name='LIB:Riley_2006'/>, B0463<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, SipB<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, Mbl<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, Lir<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, NbsA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, MtcA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, AcrA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, acridine efflux pump<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>  
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!align=left {{table_heading_style}} |Knock-Out Phenotype
!align=left |Knock-Out Phenotype
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!align=left {{table_heading_style}} |Regulation/Expression
!align=left |Regulation/Expression
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transcription unit(s): [[:Category:Txn_unit:acrAB|acrAB]]<ref name='LIB:EcoCyc10.6'/>  
transcription unit(s): [[:Category:Txn_unit:acrAB|acrAB]]<ref name='LIB:EcoCyc10.6'/>  
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!align=left {{table_heading_style}} |Regulation/Activity
!align=left |Regulation/Activity
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Revision as of 23:52, 8 January 2010

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
References Suggestions

See Help:Quickview for help with entering information in the Quickview table.

Standard Name

acrA

Gene Synonym(s)

ECK0457, b0463, JW0452, Mb, lir, mbl, mtcA, sipB, nbsA[1]

Product Desc.

AcrA Membrane Fusion Protein[2][3];

Component of AcrAB-TolC Multidrug Efflux System[2]; AcrAB-TolC Multidrug Efflux Transport System[3]

AcrAB-TolC multidrug efflux pump; additionally dye, detergent, solvent resistance; membrane-fusion lipoprotein[4]

Product Synonyms(s)

multidrug efflux system[1], B0463[2][1], SipB[2][1], Mbl[2][1], Lir[2][1], NbsA[2][1], MtcA[2][1], AcrA[2][1], acridine efflux pump[2][1]

Knock-Out Phenotype
Regulation/Expression

transcription unit(s): acrAB[2]

Regulation/Activity


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See Help:Quickview for help with entering information in the Quickview table.

Notes

[back to top]


acrA was first identified as an acridine sensitive mutation. acrA is a mutational suppressor of topA deletion inviability in low osmolarity medium. AcrA is attached to the inner membrane. acrA is an acrE paralog. AcrA is trimeric. Mar regulon. First 24 aa are a type II signal peptide.[4]



References

[back to top]


  1. ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.00 2.01 2.02 2.03 2.04 2.05 2.06 2.07 2.08 2.09 2.10 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
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