rpsL:Quickview: Difference between revisions

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!align=left {{table_heading_style}} |Gene Name
!align=left {{table_heading_style}} |Standard Name
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[[rpsL:Gene|''rpsL]]'' (synonyms: ''ECK3329, b3342, JW3304, asuB, strA'')<ref name='LIB:Riley_2006'/>
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!align=left {{table_heading_style}} |Product(s)  
!align=left {{table_heading_style}} |Gene Synonym(s)
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[[rpsL:Gene_Product(s)|RpsL product]]<ref name='LIB:Riley_2006'/>: 30S ribosomal subunit protein S12 product, B3342 product, StrA product, AsuB product
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!align=left {{table_heading_style}} |Description
!align=left {{table_heading_style}} |Product Desc.
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30S ribosomal subunit protein S12<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>
!align=left {{table_heading_style}} |Product Synonyms(s)
 
Component of [[:Category:Complex:30S ribosomal subunit|30S ribosomal subunit]]<ref name='LIB:EcoCyc10.6'/>,[[:Category:Complex:ribosome|ribosome]]<ref name='LIB:EcoCyc10.6'/>
 
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!align=left {{table_heading_style}} |Knock-Out Phenotype
!align=left {{table_heading_style}} |Knock-Out Phenotype
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!align=left {{table_heading_style}} |Regulation/Expression
!align=left {{table_heading_style}} |Regulation/Expression
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transcription unit(s): [[:Category:Txn_unit:rpsLG-fusA-tufA|rpsLG-fusA-tufA]]<ref name='LIB:EcoCyc10.6'/>
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!align=left {{table_heading_style}} |Regulation/Activity
!align=left {{table_heading_style}} |Regulation/Activity
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Revision as of 19:10, 5 March 2009

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
References Suggestions

See Help:Quickview for help with entering information in the Quickview table.

Standard Name
Gene Synonym(s)
Product Desc.
Product Synonyms(s)
Knock-Out Phenotype
Regulation/Expression
Regulation/Activity
edit table

See Help:Quickview for help with entering information in the Quickview table.

RpsL is a ribosomal gene that encodes the highly conserved rps12 protein of the ribosomal accuracy center in the Escherichia coli. Numerous mutations in the rpsL gene generate resistance to, and in some instances dependence on, high levels of streptomycin. [1]

References

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  1. ↑ Toivonen, JM et al. (1999) Modelling in Escherichia coli of mutations in mitoribosomal protein S12: novel mutant phenotypes of rpsL. Mol. Microbiol. 31 1735-46 PubMed


Mutations in regions 41-45 (except when lys42 is replaced with arg), 87-93 and 53 result in streptomycin resistance. A point mutation at 262 from A to G sustains protein synthesis in late stationary phase and increases the stability of the 70S complex in low magnesium concentrations.[1]

  1. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.