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!align=left {{table_heading_style}} |Gene Name
!align=left {{table_heading_style}} |Standard Name
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[[pnp:Gene|''pnp]]'' (synonyms: ''ECK3152, b3164, JW5851, bfl'')<ref name='LIB:Riley_2006'/>
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!align=left {{table_heading_style}} |Product(s)  
!align=left {{table_heading_style}} |Gene Synonym(s)
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[[pnp:Gene_Product(s)|Pnp product]]<ref name='LIB:Riley_2006'/>: polynucleotide phosphorylase/polyadenylase product, B3164 product, Bfl product, polynucleotide phosphorylase product
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!align=left {{table_heading_style}} |Description
!align=left {{table_heading_style}} |Product Desc.
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Pnp<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>
!align=left {{table_heading_style}} |Product Synonyms(s)
 
Component of [[:Category:Complex:polynucleotide phosphorylase|polynucleotide phosphorylase]]<ref name='LIB:EcoCyc11.1'/>,[[:Category:Complex:degradosome|degradosome]]<ref name='LIB:EcoCyc11.1'/>
 
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!align=left {{table_heading_style}} |Knock-Out Phenotype
!align=left {{table_heading_style}} |Knock-Out Phenotype
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!align=left {{table_heading_style}} |Regulation/Expression
!align=left {{table_heading_style}} |Regulation/Expression
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transcription unit(s): [[:Category:Txn_unit:rpsO-pnp|rpsO-pnp]]<ref name='LIB:EcoCyc10.6'/>, [[:Category:Txn_unit:pnp|pnp]]<ref name='LIB:EcoCyc10.6'/>, [[:Category:Txn_unit:metY-yhbC-nusA-infB-rbfA-truB-rpsO-pnp|metY-yhbC-nusA-infB-rbfA-truB-rpsO-pnp]]<ref name='LIB:EcoCyc10.6'/>
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!align=left {{table_heading_style}} |Regulation/Activity
!align=left {{table_heading_style}} |Regulation/Activity
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Revision as of 18:55, 5 March 2009

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
References Suggestions

See Help:Quickview for help with entering information in the Quickview table.

Standard Name
Gene Synonym(s)
Product Desc.
Product Synonyms(s)
Knock-Out Phenotype
Regulation/Expression
Regulation/Activity
edit table

See Help:Quickview for help with entering information in the Quickview table.

Notes

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Implicated in degadation of sRNAs[1]

Cold induction occurs by reversal of post-translational autoregulation. The pnp mRNA leader is cleaved by RNase III, allowing PNPase to repress its own translation. Mutation of Gly454 impairs autogenous regulation without affecting catalytic activity. Mutants have elevated OM vesiculation (McBroom, 2006). Pnp can add long polynucleotide tails to mRNAs terminated by Rho factor (Mohanty, 2006). The overexpression of the Pnp S1 domain suppresses the cold growth defect of quadruple cspABEG mutant strain BX04 (Xia, 2001).[2]



References

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  1. ↑ Andrade, JM & Arraiano, CM (2008) PNPase is a key player in the regulation of small RNAs that control the expression of outer membrane proteins. RNA 14 543-51 PubMed
  2. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
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