cls:Gene Product(s): Difference between revisions

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!|Qualifier!!GO ID!!GO term name!!Reference(s)!!Evidence Code!!with/from!!Aspect!!Notes!!Status
!|Qualifier!!GO ID!!GO term name!!Reference(s)!!Evidence Code!!with/from!!Aspect!!Notes!!Status
|-
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[[Category:GO:0003824_!_catalytic_activity]][http://gowiki.tamu.edu/wiki/index.php/Category:GO:0003824_!_catalytic_activity GO:0003824]
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catalytic activity
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[http://www.geneontology.org/cgi-bin/references.cgi#GO_REF:0000002 GO_REF:0000002]
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IEA: Inferred from Electronic Annotation
|
[http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR001736 InterPro:IPR001736]
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F
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
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complete
|-
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[[Category:GO:0008152_!_metabolic_process]][http://gowiki.tamu.edu/wiki/index.php/Category:GO:0008152_!_metabolic_process GO:0008152]
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metabolic process
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[http://www.geneontology.org/cgi-bin/references.cgi#GO_REF:0000002 GO_REF:0000002]
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IEA: Inferred from Electronic Annotation
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[http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR001736 InterPro:IPR001736]
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P
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
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complete
|-
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|
[[Category:GO:0008654_!_phospholipid_biosynthetic_process]][http://gowiki.tamu.edu/wiki/index.php/Category:GO:0008654_!_phospholipid_biosynthetic_process GO:0008654]
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phospholipid biosynthetic process
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[http://www.geneontology.org/cgi-bin/references.cgi#GO_REF:0000020 GO_REF:0000020]
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IEA: Inferred from Electronic Annotation
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HAMAP:MF_00190
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P
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
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complete
|-
|
|
[[Category:GO:0008654_!_phospholipid_biosynthetic_process]][http://gowiki.tamu.edu/wiki/index.php/Category:GO:0008654_!_phospholipid_biosynthetic_process GO:0008654]
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phospholipid biosynthetic process
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[http://www.geneontology.org/cgi-bin/references.cgi#GO_REF:0000004 GO_REF:0000004]
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IEA: Inferred from Electronic Annotation
|
[http://www.uniprot.org/keywords/KW-0594 SP_KW:KW-0594]
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P
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
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complete
|-
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|
[[Category:GO:0016020_!_membrane]][http://gowiki.tamu.edu/wiki/index.php/Category:GO:0016020_!_membrane GO:0016020]
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membrane
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[http://www.geneontology.org/cgi-bin/references.cgi#GO_REF:0000004 GO_REF:0000004]
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IEA: Inferred from Electronic Annotation
|
[http://www.uniprot.org/keywords/KW-0397 SP_KW:KW-0397]
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C
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Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
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complete
|-
|
|
[[Category:GO:0016020_!_membrane]][http://gowiki.tamu.edu/wiki/index.php/Category:GO:0016020_!_membrane GO:0016020]
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membrane
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[http://www.geneontology.org/cgi-bin/references.cgi#GO_REF:0000004 GO_REF:0000004]
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IEA: Inferred from Electronic Annotation
|
[http://www.uniprot.org/keywords/KW-0472 SP_KW:KW-0472]
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C
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
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complete
|-
|
|
[[Category:GO:0016021_!_integral_to_membrane]][http://gowiki.tamu.edu/wiki/index.php/Category:GO:0016021_!_integral_to_membrane GO:0016021]
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integral to membrane
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[http://www.geneontology.org/cgi-bin/references.cgi#GO_REF:0000004 GO_REF:0000004]
|
IEA: Inferred from Electronic Annotation
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[http://www.uniprot.org/keywords/KW-0812 SP_KW:KW-0812]
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C
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
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complete
|-
|
|
[[Category:GO:0016740_!_transferase_activity]][http://gowiki.tamu.edu/wiki/index.php/Category:GO:0016740_!_transferase_activity GO:0016740]
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transferase activity
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[http://www.geneontology.org/cgi-bin/references.cgi#GO_REF:0000004 GO_REF:0000004]
|
IEA: Inferred from Electronic Annotation
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[http://www.uniprot.org/keywords/KW-0808 SP_KW:KW-0808]
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F
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
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complete
|-
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|
[[Category:GO:0016780_!_phosphotransferase_activity,_for_other_substituted_phosphate_groups]][http://gowiki.tamu.edu/wiki/index.php/Category:GO:0016780_!_phosphotransferase_activity,_for_other_substituted_phosphate_groups GO:0016780]
|
phosphotransferase activity, for other substituted phosphate groups
|
[http://www.geneontology.org/cgi-bin/references.cgi#GO_REF:0000020 GO_REF:0000020]
|
IEA: Inferred from Electronic Annotation
|
HAMAP:MF_00190
|
F
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
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complete
|-  
|-  
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!Compartment!!Description!!Evidence!!Notes
!|Compartment!!Description!!Evidence!!Notes
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plasma membrane
plasma membrane
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From EcoCyc<ref name='LIB:EcoCyc11.1'/>   
From EcoCyc<ref name='LIB:EcoCyc11.1'/>   
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!{{table heading style}} |Sequence
!align=left {{table heading style}} |Sequence
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[http://biocyc.org/ECOLI/sequence-aa?object=CARDIOLIPSYN-MONOMER at EcoCyc]  
[http://biocyc.org/ECOLI/sequence-aa?object=CARDIOLIPSYN-MONOMER at EcoCyc]  
<pre>MTTVYTLVSW LAILGYWLLI AGVTLRILMK RRAVPSAMAW LLIIYILPLV GIIAYLAVGE
<pre>MTTVYTLVSW LAILGYWLLI AGVTLRILMK RRAVPSAMAW LLIIYILPLV GIIAYLAVGE
Line 368: Line 200:
FFSPLL</pre>  
FFSPLL</pre>  
|-
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!{{table heading style}} |Mol. Wt
!align=left {{table heading style}} |Mol. Wt
|
||
54.82 kDa (calc) <ref name='LIB:EcoCyc10.6'/>  
54.82 kDa (calc) <ref name='LIB:EcoCyc10.6'/>  
|-
|-
!{{table heading style}} |pI
!align=left {{table heading style}} |pI
|
||
   
   
|-
|-
!{{table heading style}} |Extinction coefficient
!align=left {{table heading style}} |Extinction coefficient
|
||
93850 - 94475 (calc based on 15 Y, 13 W, and 5 C residues)  
93850 - 94475 (calc based on 15 Y, 13 W, and 5 C residues)  
|-
 
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Domain
Domain
|
|
10 - 29
399 - 426
|
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Predicted membrane-spanning helix.
[[interpro:IPR001736|PLD phosphodiesterase 2]]
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TMD predicted by [http://www.cbs.dtu.dk/services/TMHMM TMHMM]<ref name='PMID:11152613' />
[http://www.uniprot.org/uniprot/P0A6H8#section_features UniProt:P0A6H8]  
|-  
|-  
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Domain
Domain
|
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36 - 58
10 - 29
|
|
Predicted membrane-spanning helix.
Predicted membrane-spanning helix.
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Domain
Domain
|
|
399 - 426
36 - 58
|
|
[[interpro:IPR001736|PLD phosphodiesterase 2]]
Predicted membrane-spanning helix.
|
|
[http://www.uniprot.org/uniprot/P0A6H8#section_features UniProt:P0A6H8]
TMD predicted by [http://www.cbs.dtu.dk/services/TMHMM TMHMM]<ref name='PMID:11152613' />


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!Database!!Accession!!Notes
!|Database!!Accession!!Notes
|-
|-  
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[http://ecocyc.org EcoCyc] ([[EcoCyc|EcoliWiki Page]])  
[http://ecocyc.org EcoCyc] ([[EcoCyc|EcoliWiki Page]])  
|
|
[http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=CARDIOLIPSYN-MONOMER EcoCyc:CARDIOLIPSYN-MONOMER]
[http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=CARDIOLIPSYN-MONOMER EcoCyc:CARDIOLIPSYN-MONOMER]
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|-
|-  
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[http://uniprot.org/ UniProt] ([[UniProt|EcoliWiki Page]])  
[http://uniprot.org/ UniProt] ([[UniProt|EcoliWiki Page]])  
|
|
[[uniprot:P0A6H8|UniProt:P0A6H8]]
[[uniprot:P0A6H8|UniProt:P0A6H8]]
|
|
   
   
|-
|-  
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[http://pfam.sanger.ac.uk/ PFAM] ([[PFAM|EcoliWiki Page]])  
[http://pfam.sanger.ac.uk/ PFAM] ([[PFAM|EcoliWiki Page]])  
|
|
[http://pfam.sanger.ac.uk/family?acc=PF00614 PFAM:PF00614]
[http://pfam.sanger.ac.uk/family?acc=PF00614 PFAM:PF00614]
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|
   
   
|-
|-  
|
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[http://www.ncbi.nlm.nih.gov/RefSeq/ RefSeq] ([[RefSeq|EcoliWiki Page]])  
[http://www.ncbi.nlm.nih.gov/RefSeq/ RefSeq] ([[RefSeq|EcoliWiki Page]])  
|
|
[http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=NP_415765 RefSeq:NP_415765]
[http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=NP_415765 RefSeq:NP_415765]
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|-
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[http://modbase.compbio.ucsf.edu ModBase] ([[ModBase|EcoliWiki Page]])  
[http://modbase.compbio.ucsf.edu ModBase] ([[ModBase|EcoliWiki Page]])  
|
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[http://salilab.org/modbase/searchbyid?databaseID=P0A6H8 ModBase:P0A6H8]
[http://salilab.org/modbase/searchbyid?databaseID=P0A6H8 ModBase:P0A6H8]
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Revision as of 01:29, 15 November 2008

{{#css:Suppresslinks.css}}<css>h1 .editsection { display:none;} h2 .editsection { display:none;}</css>

Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

Standard name

Cls

Synonyms

cardiolipin synthase 1[1], B1249[2][1], YciJ[2][1], Nov product[2][1], Cls product[2][1]

Product description

CARDIOLIPSYN-MONOMER[2][3]

EC number (for enzymes)
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See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Notes

Function

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Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference(s) Evidence Code with/from Aspect Notes Status
GO:0042493

response to drug

P

Seeded from EcoCyc 11.1[3].

required fields missing

GO:0008808

cardiolipin synthase activity

PMID:353047[4]

IMP: Inferred from Mutant Phenotype

F

complete

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Interactions

Partner Type Partner Notes
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See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Notes

Required for synthesis of cardiolipin.

Localization

Compartment Description Evidence Notes

plasma membrane

From EcoCyc[3]

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See Help:Product_localization for how to add or edit information in this section of EcoliWiki.


Notes

Structure and Physical Properties

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Physical Properties

Sequence

at EcoCyc 

MTTVYTLVSW LAILGYWLLI AGVTLRILMK RRAVPSAMAW LLIIYILPLV GIIAYLAVGE
LHLGKRRAER ARAMWPSTAK WLNDLKACKH IFAEENSSVA APLFKLCERR QGIAGVKGNQ
LQLMTESDDV MQALIRDIQL ARHNIEMVFY IWQPGGMADQ VAESLMAAAR RGIHCRLMLD
SAGSVAFFRS PWPELMRNAG IEVVEALKVN LMRVFLRRMD LRQHRKMIMI DNYIAYTGSM
NMVDPRYFKQ DAGVGQWIDL MARMEGPIAT AMGIIYSCDW EIETGKRILP PPPDVNIMPF
EQASGHTIHT IASGPGFPED LIHQALLTAA YSAREYLIMT TPYFVPSDDL LHAICTAAQR
GVDVSIILPR KNDSMLVGWA SRAFFTELLA AGVKIYQFEG GLLHTKSVLV DGELSLVGTV
NLDMRSLWLN FEITLAIDDK GFGADLAAVQ DDYISRSRLL DARLWLKRPL WQRVAERLFY
FFSPLL
Mol. Wt

54.82 kDa (calc) [2]

pI
Extinction coefficient

93850 - 94475 (calc based on 15 Y, 13 W, and 5 C residues)

edit table

See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Domains/Motifs/Modification Sites

Type Residues Description Notes

Domain

219 - 246

PLD phosphodiesterase 1

UniProt:P0A6H8

Domain

399 - 426

PLD phosphodiesterase 2

UniProt:P0A6H8

Domain

10 - 29

Predicted membrane-spanning helix.

TMD predicted by TMHMM[5]

Domain

36 - 58

Predicted membrane-spanning helix.

TMD predicted by TMHMM[5]

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See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

tmhmm.php?gene=cls&show=pic&.jpg
Click the image to view raw output from TMHMM.

Structure

Structures

<beststructure>cls 562</beststructure>

Models

View models at:

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See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Notes

Gene Product Resources

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Resource type Source Notes/Reference
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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Notes

Accessions in Other Databases

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Database Accession Notes

EcoCyc (EcoliWiki Page)

EcoCyc:CARDIOLIPSYN-MONOMER

UniProt (EcoliWiki Page)

UniProt:P0A6H8

PFAM (EcoliWiki Page)

PFAM:PF00614

RefSeq (EcoliWiki Page)

RefSeq:NP_415765

ModBase (EcoliWiki Page)

ModBase:P0A6H8


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See Help:Product_accessions for help entering or editing information in this section of EcoliWiki.

Notes

Links

[back to top]


Name URL Comments
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See Help:Links_table for how to enter or edit information in this section of EcoliWiki.



References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 3.2 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ Pluschke, G et al. (1978) Function of phospholipids in Escherichia coli. Characterization of a mutant deficient in cardiolipin synthesis. J. Biol. Chem. 253 5048-55 PubMed
  5. ↑ 5.0 5.1 Krogh, A et al. (2001) Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes. J. Mol. Biol. 305 567-80 PubMed


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