cls:Gene Product(s): Difference between revisions

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!|Type!!Residues!!Description!!Notes
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Domain
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219 - 246
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[[interpro:IPR001736|PLD phosphodiesterase 1]]
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[http://www.uniprot.org/uniprot/P0A6H8#section_features UniProt:P0A6H8]
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Domain
Domain
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219 - 246
399 - 426
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[[interpro:IPR001736|PLD phosphodiesterase 1]]
[[interpro:IPR001736|PLD phosphodiesterase 2]]
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[http://www.uniprot.org/uniprot/P0A6H8#section_features UniProt:P0A6H8]  
[http://www.uniprot.org/uniprot/P0A6H8#section_features UniProt:P0A6H8]  

Revision as of 21:22, 30 October 2008

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
Nomenclature Function Interactions Localization Sequence Structure Resources Accessions Links References Suggestions

Nomenclature

Standard name

Cls

Synonyms

cardiolipin synthase 1[1], B1249[2][1], YciJ[2][1], Nov product[2][1], Cls product[2][1]

Product description

CARDIOLIPSYN-MONOMER[2][3]

EC number (for enzymes)
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Notes

Function

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Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference(s) Evidence Code with/from Aspect Notes Status
GO:0003824

catalytic activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001736

F

Seeded from EcoCyc 12.5 [4]

complete

GO:0008152

metabolic process

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001736

P

Seeded from EcoCyc 12.5 [4]

complete

GO:0008654

phospholipid biosynthetic process

GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00190

P

Seeded from EcoCyc 12.5 [4]

complete

GO:0008654

phospholipid biosynthetic process

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0594

P

Seeded from EcoCyc 12.5 [4]

complete

GO:0016020

membrane

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0397

C

Seeded from EcoCyc 12.5 [4]

complete

GO:0016020

membrane

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0472

C

Seeded from EcoCyc 12.5 [4]

complete

GO:0016021

integral to membrane

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0812

C

Seeded from EcoCyc 12.5 [4]

complete

GO:0016740

transferase activity

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0808

F

Seeded from EcoCyc 12.5 [4]

complete

GO:0016780

phosphotransferase activity, for other substituted phosphate groups

GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00190

F

Seeded from EcoCyc 12.5 [4]

complete

GO:0042493

response to drug

P

Seeded from EcoCyc 11.1[3].

required fields missing

GO:0008808

cardiolipin synthase activity

PMID:353047[5]

IMP: Inferred from Mutant Phenotype

F

complete

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Interactions

Partner Type Partner Notes
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See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Notes

Required for synthesis of cardiolipin.

Localization

Compartment Description Evidence Notes

plasma membrane

From EcoCyc[3]

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See Help:Product_localization for how to add or edit information in this section of EcoliWiki.


Notes

Structure and Physical Properties

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Physical Properties

Sequence

at EcoCyc 

MTTVYTLVSW LAILGYWLLI AGVTLRILMK RRAVPSAMAW LLIIYILPLV GIIAYLAVGE
LHLGKRRAER ARAMWPSTAK WLNDLKACKH IFAEENSSVA APLFKLCERR QGIAGVKGNQ
LQLMTESDDV MQALIRDIQL ARHNIEMVFY IWQPGGMADQ VAESLMAAAR RGIHCRLMLD
SAGSVAFFRS PWPELMRNAG IEVVEALKVN LMRVFLRRMD LRQHRKMIMI DNYIAYTGSM
NMVDPRYFKQ DAGVGQWIDL MARMEGPIAT AMGIIYSCDW EIETGKRILP PPPDVNIMPF
EQASGHTIHT IASGPGFPED LIHQALLTAA YSAREYLIMT TPYFVPSDDL LHAICTAAQR
GVDVSIILPR KNDSMLVGWA SRAFFTELLA AGVKIYQFEG GLLHTKSVLV DGELSLVGTV
NLDMRSLWLN FEITLAIDDK GFGADLAAVQ DDYISRSRLL DARLWLKRPL WQRVAERLFY
FFSPLL
Mol. Wt

54.82 kDa (calc) [2]

pI
Extinction coefficient

93850 - 94475 (calc based on 15 Y, 13 W, and 5 C residues)

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See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Domains/Motifs/Modification Sites

Type Residues Description Notes

Domain

219 - 246

PLD phosphodiesterase 1

UniProt:P0A6H8

Domain

10 - 29

Predicted membrane-spanning helix.

TMD predicted by TMHMM[6]

Domain

36 - 58

Predicted membrane-spanning helix.

TMD predicted by TMHMM[6]

Domain

399 - 426

PLD phosphodiesterase 2

UniProt:P0A6H8

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See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

tmhmm.php?gene=cls&show=pic&.jpg
Click the image to view raw output from TMHMM.

Structure

Structures

<beststructure>cls 562</beststructure>

Models

View models at:

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See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Notes

Gene Product Resources

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Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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Database Accession Notes

EcoCyc (EcoliWiki Page)

EcoCyc:CARDIOLIPSYN-MONOMER

UniProt (EcoliWiki Page)

UniProt:P0A6H8

PFAM (EcoliWiki Page)

PFAM:PF00614

RefSeq (EcoliWiki Page)

RefSeq:NP_415765

ModBase (EcoliWiki Page)

ModBase:P0A6H8

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Notes

Links

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Name URL Comments
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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 3.2 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ 4.0 4.1 4.2 4.3 4.4 4.5 4.6 4.7 4.8 EcoCyc (release 12.5; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  5. ↑ Pluschke, G et al. (1978) Function of phospholipids in Escherichia coli. Characterization of a mutant deficient in cardiolipin synthesis. J. Biol. Chem. 253 5048-55 PubMed
  6. ↑ 6.0 6.1 Krogh, A et al. (2001) Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes. J. Mol. Biol. 305 567-80 PubMed


Categories

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