Phage T4: Difference between revisions

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Bacteriophage T4 is a member of the [http://www.ictvonline.org/virusTaxonomy.asp?bhcp=1 ICTV] family [[:Category:Myoviridae|myoviridae]], long-tailed viruses with contractile tails.  T4 is the namesake of the T4-like virus genus.
Bacteriophage T4 is a member of the [http://www.ictvonline.org/virusTaxonomy.asp?bhcp=1 ICTV] family [[:Category:Myoviridae|myoviridae]], long-tailed viruses with contractile tails.  T4 is the namesake of the T4-like virus genus.  T4 and its relatives were used for many of the key experiments in the history of molecular biology.


== Morphology ==
== Morphology ==

Revision as of 04:12, 30 May 2011

Bacteriophage T4 is a member of the ICTV family myoviridae, long-tailed viruses with contractile tails. T4 is the namesake of the T4-like virus genus. T4 and its relatives were used for many of the key experiments in the history of molecular biology.

Morphology

Genome Organization

T4 has a circular genetic map[1], but the T4 genome is physically packaged as linear dsDNA. Headful packaging incorporates DNA that is circularly permuted[2] and terminally redundant[3] with respect to the genetic map.

Life cycle

Lytic cycle

Adsorbtion and Injection

Early gene expression

Middle gene expression

DNA replication

Late gene expression

Packaging

Lysis

See also

References

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  1. ↑ STREISINGER, G et al. (1964) CHROMOSOME STRUCTURE IN PHAGE T4. I. CIRCULARITY OF THE LINKAGE MAP. Proc. Natl. Acad. Sci. U.S.A. 51 775-9 PubMed
  2. ↑ THOMAS, CA Jr & RUBENSTEIN, I (1964) THE ARRANGEMENTS OF NUCLEOTIDE SEQUENCES IN T2 AND T5 BACTERIOPHAGE DNA MOLECULES. Biophys. J. 4 93-106 PubMed
  3. ↑ Séchaud, J et al. (1965) Chromosome structure in phage T4, II. Terminal redundancy and heterozygosis. Proc. Natl. Acad. Sci. U.S.A. 54 1333-9 PubMed