Phage T4: Difference between revisions

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== Genome Organization ==
== Genome Organization ==
T4 has a circular genetic map, but the T4 genome is physically packaged as linear dsDNA.  Headful packaging incorporates DNA that is circularly permuted and terminally redundant with respect to the genetic map.
T4 has a circular genetic map<ref name='PMID:14172990'/>, but the T4 genome is physically packaged as linear dsDNA.  Headful packaging incorporates DNA that is circularly permuted<ref name='PMID:14130440'/> and terminally redundant<ref name='PMID:4222403'/> with respect to the genetic map.


== Life cycle ==
== Life cycle ==

Revision as of 04:11, 30 May 2011

Bacteriophage T4 is a member of the ICTV family myoviridae, long-tailed viruses with contractile tails. T4 is the namesake of the T4-like virus genus.

Morphology

Genome Organization

T4 has a circular genetic map[1], but the T4 genome is physically packaged as linear dsDNA. Headful packaging incorporates DNA that is circularly permuted[2] and terminally redundant[3] with respect to the genetic map.

Life cycle

Lytic cycle

Adsorbtion and Injection

Early gene expression

Middle gene expression

DNA replication

Late gene expression

Packaging

Lysis

See also

References

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  1. ↑ STREISINGER, G et al. (1964) CHROMOSOME STRUCTURE IN PHAGE T4. I. CIRCULARITY OF THE LINKAGE MAP. Proc. Natl. Acad. Sci. U.S.A. 51 775-9 PubMed
  2. ↑ THOMAS, CA Jr & RUBENSTEIN, I (1964) THE ARRANGEMENTS OF NUCLEOTIDE SEQUENCES IN T2 AND T5 BACTERIOPHAGE DNA MOLECULES. Biophys. J. 4 93-106 PubMed
  3. ↑ Séchaud, J et al. (1965) Chromosome structure in phage T4, II. Terminal redundancy and heterozygosis. Proc. Natl. Acad. Sci. U.S.A. 54 1333-9 PubMed