SOS Response: Difference between revisions
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==Regulation== | ==Regulation== | ||
RecA bound to single-stranded DNA leads to its activation. This activated form of RecA, or RecA* causes autocleavage of the LexA repressor<ref name='PMID:6814506'/>. | |||
==Cell Biology== | ==Cell Biology== | ||
Revision as of 16:07, 2 July 2010
See Help:Processes for more information about physiological processes in EcoliWiki.
General Description
A set of reversible checkpoints induced upon DNA damage, or regions of single stranded DNA.
Components
Function
Regulation
RecA bound to single-stranded DNA leads to its activation. This activated form of RecA, or RecA* causes autocleavage of the LexA repressor[1].
Cell Biology
The expression of multiple genes is upregulated upon induction of the SOS response. The LexA repressor control the expression of:
Experimental Resources
Several antibiotics induce the SOS response
- mitomycin C (working concentration-0.1 µg/ml)[3]
Comparison with other organisms
Notes
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References
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- ↑ Little, JW () Control of the SOS regulatory system by the level of RecA protease. Biochimie 64 585-9 PubMed
- ↑ Mizusawa, S et al. (1983) Transcription of the sulA gene and repression by LexA. J. Mol. Biol. 171 337-43 PubMed
- ↑ 3.0 3.1 Wang, L & Lutkenhaus, J (1998) FtsK is an essential cell division protein that is localized to the septum and induced as part of the SOS response. Mol. Microbiol. 29 731-40 PubMed
- ↑ Sancar, A et al. (1982) LexA protein inhibits transcription of the E. coli uvrA gene in vitro. Nature 298 96-8 PubMed