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!align=left {{table_heading_style}} |Function from GO
!align=left {{table_heading_style}} |Function from GO
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'''Molecular Function'''
<GO_nr />
* GO:0004000 adenosine deaminase activity ([http://www.geneontology.org/GO.evidence.shtml IDA,IMP])
* GO:0005488 binding ([http://www.geneontology.org/GO.evidence.shtml ISS])
'''Biological Process'''
* GO:0015950 purine nucleotide interconversion ([http://www.geneontology.org/GO.evidence.shtml IGI])
* GO:0009168 purine ribonucleoside monophosphate biosynthetic process ([http://www.geneontology.org/GO.evidence.shtml IGI])
* GO:0006154 adenosine catabolic process ([http://www.geneontology.org/GO.evidence.shtml IGI])
* GO:0032261 purine nucleotide salvage ([http://www.geneontology.org/GO.evidence.shtml IGI])
* GO:0043103 hypoxanthine salvage ([http://www.geneontology.org/GO.evidence.shtml IGI])
* GO:0046101 hypoxanthine biosynthetic process ([http://www.geneontology.org/GO.evidence.shtml IGI])
'''Cellular Component'''
* GO:0005737 cytoplasm ([http://www.geneontology.org/GO.evidence.shtml IC])
 
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!align=left {{table_heading_style}} |Knock-Out Phenotype
!align=left {{table_heading_style}} |Knock-Out Phenotype

Revision as of 19:49, 2 February 2010

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
References Suggestions

See Help:Quickview for help with entering information in the Quickview table.

Standard Name

add

Gene Synonym(s)

ECK1618, b1623, JW1615[1]

Product Desc.

Adenosine deaminase; mutants affect growth on deoxyadenosine in purA, B mutants[2]

Product Synonyms(s)

adenosine deaminase[1], B1623[3][1], Add[3][1]

Function from GO

<GO_nr />

Knock-Out Phenotype
Regulation/Expression

transcription unit(s): add[3]

Regulation/Activity
Quick Links

DNA display    Protein display    Pubmed(add)    Textpresso(add)

edit table

See Help:Quickview for help with entering information in the Quickview table.

Notes

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Adenosine deaminase is an enzyme involved in purine metabolism, which irreversibly deaminates both adenosine and deoxyadenosine to inosine and deoxyinosine. The optimal pH for this enzyme is around 7.5-8, but activity is irreversibly lost when pH is lower than 2.7 or higher than 9.5. Adenosine deaminase is sensitive to heavy metals, such as Ag+, Cu2+, and Cr3+, and reacts with them irreversibly (Koch, 1958). [4]

Complications in purine metabolism often result in various disorders in humans. Deficiencies amounts of adenosine deaminase result in diseases such as severe combined immunodeficiency disorder (SCID) and lymphopenia.

Binds TrxA (Kumar, 2004).[2]



References

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  1. ↑ 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  3. ↑ 3.0 3.1 3.2 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ KOCH, AL & VALLEE, G (1959) The properties of adenosine deaminase and adenosine nucleoside phosphorylase in extracts of Escherichia coli. J. Biol. Chem. 234 1213-8 PubMed


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