ftsK:Quickview: Difference between revisions

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!align=left {{table_heading_style}} |Function from GO
!align=left {{table_heading_style}} |Function from GO
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'''Molecular Function'''
<GO_nr />
* GO:0005515 protein binding ([http://www.geneontology.org/GO.evidence.shtml IPI])
* GO:0003677 DNA binding ([http://www.geneontology.org/GO.evidence.shtml IDA])
* GO:0016887 ATPase activity ([http://www.geneontology.org/GO.evidence.shtml IDA])
'''Biological Process'''
* GO:0009432 SOS response ([http://www.geneontology.org/GO.evidence.shtml IEP])
* GO:0051301 cell division ([http://www.geneontology.org/GO.evidence.shtml IMP])
* GO:0007059 chromosome segregation ([http://www.geneontology.org/GO.evidence.shtml IMP,IGI])
* GO:0006970 response to osmotic stress ([http://www.geneontology.org/GO.evidence.shtml IMP])
* GO:0045941 positive regulation of transcription ([http://www.geneontology.org/GO.evidence.shtml IMP])
* GO:0009651 response to salt stress ([http://www.geneontology.org/GO.evidence.shtml IMP])
* GO:0000920 cell separation during cytokinesis ([http://www.geneontology.org/GO.evidence.shtml IMP])
'''Cellular Component'''
* GO:0005886 plasma membrane ([http://www.geneontology.org/GO.evidence.shtml EXP])
 
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!align=left {{table_heading_style}} |Knock-Out Phenotype
!align=left {{table_heading_style}} |Knock-Out Phenotype

Revision as of 19:41, 2 February 2010

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
References Suggestions

See Help:Quickview for help with entering information in the Quickview table.

Standard Name

ftsK

Gene Synonym(s)

ECK0881, b0890, JW0873, dinH[1]

Product Desc.

essential cell division protein FtsK[2][3];

Component of Xer site-specific recombination system[3]

DNA translocase at septal ring sorting daughter chromsomes[4]

Product Synonyms(s)

DNA-binding membrane protein required for chromosome resolution and partitioning[1], B0890[2][1], DinH[2][1], FtsK[2][1]

Function from GO

<GO_nr />

Knock-Out Phenotype

ts mutants filament

Regulation/Expression

transcription unit(s): ftsK[2], dinH

Regulation/Activity
Quick Links

DNA display    Protein display    Pubmed(ftsK)    Textpresso(ftsK)

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Notes

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FtsK is required for resolution of chromosome dimers at dif by XerCD. FtsK helps keep the nucleoids properly localized, recognizing opposing replichores by using FtsK orienting polar sequences (KOPS). The N-terminal domain is membrane-anchored, localizes to the division septum and is required for cell division. The C-terminal domain has the non-essential translocase activity, which becomes essential for replicating the asymmetric replichores produced by chromosome inversion (Lesterlin, 2008). LexA regulon. Homologous to B. subtilis SpoIIIE protein. The ftsK gene is essential. The filamentous growth of mutants is suppressed by dacA deletions. ftsK44(ts) can be suppressed by an ftsA R286W mutation or by an ftsQAZ plasmid. Divisome.[4]



References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
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