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!align=left {{table_heading_style}} |Function from GO
!align=left {{table_heading_style}} |Function from GO
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'''Molecular Function'''
<GO_nr />
* GO:0005515 protein binding ([http://www.geneontology.org/GO.evidence.shtml IPI,IDA])
* GO:0015288 porin activity ([http://www.geneontology.org/GO.evidence.shtml IDA])
'''Biological Process'''
* GO:0006810 transport ([http://www.geneontology.org/GO.evidence.shtml IDA])
* GO:0046718 entry of virus into host cell ([http://www.geneontology.org/GO.evidence.shtml IMP])
* GO:0000746 conjugation ([http://www.geneontology.org/GO.evidence.shtml IMP])
* GO:0009597 detection of virus ([http://www.geneontology.org/GO.evidence.shtml IMP])
* GO:0006811 ion transport ([http://www.geneontology.org/GO.evidence.shtml IDA])
'''Cellular Component'''
* GO:0016020 membrane ([http://www.geneontology.org/GO.evidence.shtml IDA])
* GO:0009279 cell outer membrane ([http://www.geneontology.org/GO.evidence.shtml IDA])
* GO:0019867 outer membrane ([http://www.geneontology.org/GO.evidence.shtml IDA])
* GO:0016021 integral to membrane ([http://www.geneontology.org/GO.evidence.shtml IDA])
 
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!align=left {{table_heading_style}} |Knock-Out Phenotype
!align=left {{table_heading_style}} |Knock-Out Phenotype

Revision as of 19:31, 2 February 2010

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
References Suggestions

See Help:Quickview for help with entering information in the Quickview table.

Standard Name

ompA

Gene Synonym(s)

ECK0948, b0957, JW0940, con, tolG, tut[1]

Product Desc.

outer membrane protein 3a (II*;G;d)[2][3]

Outer membrane protein A; Outer membrane porin A; T-even phage receptor; weak porin; homodimer, abundant cell surface protein[4]

Discovered to influence biofilm formation[5]

OmpA inhibits cellulose production through the CpxRA stress response system, and this reduction in cellulose increases biofilm formation on hydrophobic surfaces[6]. Deletion of ompA increases cellulose which decreases biofilm formation on hydrophobic surfaces[6].

Product Synonyms(s)

outer membrane protein A (3a;II*;G;d)[1], B0957[2][1], Tut[2][1], Con[2][1], TolG[2][1], OmpA[2][1]


Function from GO

<GO_nr />

Knock-Out Phenotype
Regulation/Expression

transcription unit(s): ompA[2], OP00064

Regulation/Activity
Quick Links

DNA display    Protein display    Pubmed(ompA)    Textpresso(ompA)

See Help:Quickview for help with entering information in the Quickview table.

Notes

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OmpA is required for colicins K and L and the stabilization of mating aggregates. OmpA is elevated 5X during growth at 4C (enabled by Oleispira antarctica Cpn10/60 transgene). OmpA expression is elevated during biofilm formation (Orme, 2006). OmpA is required for biofilm formation under some condtions. Translation of OmpF is inhibited by the rseX sRNA. Alkali-inducible Binds TrxA (Kumar, 2004). Perhaps because it is so abundant, OmpA is found in some inner membrane preparations.[4]



References

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  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ Barrios, AF et al. (2006) Hha, YbaJ, and OmpA regulate Escherichia coli K12 biofilm formation and conjugation plasmids abolish motility. Biotechnol. Bioeng. 93 188-200 PubMed
  6. ↑ 6.0 6.1 Ma, Q & Wood, TK (2009) OmpA influences Escherichia coli biofilm formation by repressing cellulose production through the CpxRA two-component system. Environ. Microbiol. 11 2735-46 PubMed