rppH:Quickview: Difference between revisions

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!align=left {{table_heading_style}} |Function from GO
!align=left {{table_heading_style}} |Function from GO
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'''Biological Process'''
<GO_nr />
* GO:0050779 RNA destabilization ([http://www.geneontology.org/GO.evidence.shtml IMP])
* GO:0050779 RNA_destabilization ([http://www.geneontology.org/GO.evidence.shtml IMP])
'''Molecular Function'''
* GO:0034353 RNA pyrophosphohydrolase activity ([http://www.geneontology.org/GO.evidence.shtml IDA])
* GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides ([http://www.geneontology.org/GO.evidence.shtml IDA])
 
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!align=left {{table_heading_style}} |Knock-Out Phenotype
!align=left {{table_heading_style}} |Knock-Out Phenotype

Revision as of 19:30, 2 February 2010

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
References Suggestions

See Help:Quickview for help with entering information in the Quickview table.

Standard Name

rppH [1]

Gene Synonym(s)

nudH, ECK2826, b2830, JW2798, ydgP, ygdP[2]

Product Desc.

RNA pyrophosphohydrolase (removes the 5'-pyrophosphate from mRNAs and initiates degradation by the 5'-end dependent pathway)[1]; putative invasion protein[3][4] RNA pyrophosphohydrolase, destabilizes primary transcripts[5]

Product Synonyms(s)

NudH,nucleotide hydrolase[2], B2830[3][2], NudH[3][2], YgdP[3][2]

Function from GO

<GO_nr />

Knock-Out Phenotype

Many mRNAs have an increased half-life. [1]

Regulation/Expression

transcription unit(s): ptsP[3]

Regulation/Activity
Quick Links

DNA display    Protein display    Pubmed(rppH)    Textpresso(rppH)

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Notes

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Nudix hydrolase. RppH removes 5' triphosphate from primary transcripts, enhancing RNase E activity (Deana, 2008). Required for invasion of cultured mammalian cells by both E. coli K1 and S. typhimurium. NudH also hydrolyzes Ap5A and Ap4A. Ribosome-associated protein (Jiang, 2007).[5]



References

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  1. ↑ 1.0 1.1 1.2 Deana, A et al. (2008) The bacterial enzyme RppH triggers messenger RNA degradation by 5' pyrophosphate removal. Nature 451 355-8 PubMed
  2. ↑ 2.0 2.1 2.2 2.3 2.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  3. ↑ 3.0 3.1 3.2 3.3 3.4 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  5. ↑ 5.0 5.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
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