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{{Tab On|Quickview|lepB}}{{Tab|Gene|lepB}}{{Tab|Gene Product(s)|lepB}}{{Tab|Expression|lepB}}{{Tab|Evolution|lepB}}{{Tab|On One Page|lepB}}{{TabsBottom}}
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!{{table_heading_style}} |Gene Name
!align=left {{table_heading_style}} |Standard Name
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[[lepB:Gene|''lepB]]'' (synonyms: ''ECK2566, b2568, JW2552, lep'')<ref name='LIB:Riley_2006'/>
''lepB''
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!{{table_heading_style}} |Product(s)  
!align=left {{table_heading_style}} |Gene Synonym(s)
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[[lepB:Gene_Product(s)|LepB product]]<ref name='LIB:Riley_2006'/>: leader peptidase (signal peptidase I) product, B2568 product, Lep product, LP1 product
''ECK2566, b2568, JW2552, lep''<ref name='LIB:Riley_2006'/>, lep''
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!{{table_heading_style}} |Description
!align=left {{table_heading_style}} |Product Desc.
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leader peptidase (signal peptidase I)<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>  
leader peptidase (signal peptidase I)<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>


Signal peptidase I; SPI; responsible for type I signal cleavages of periplasmic, OM, some IM, and extracellular proteins<ref name='LIB:EcoGene'/>
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!align=left {{table_heading_style}} |Product Synonyms(s)
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''leader peptidase (signal peptidase I)<ref name='LIB:Riley_2006'/>, B2568<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, Lep<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, LepB<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, LP1<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/> , ECK2566, JW2552, lep, b2568''
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!align=left {{table_heading_style}} |Function from GO
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<GO_nr />
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!{{table_heading_style}} |Knock-Out Phenotype
!align=left {{table_heading_style}} |Knock-Out Phenotype
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|-
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!{{table_heading_style}} |Regulation/Expression
!align=left {{table_heading_style}} |Regulation/Expression
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transcription unit(s): [[:Category:Txn_unit:lepAB|lepAB]]<ref name='LIB:EcoCyc10.6'/>  
transcription unit(s): [[:Category:Txn_unit:lepAB|lepAB]]<ref name='LIB:EcoCyc10.6'/>  
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!{{table_heading_style}} |Regulation/Activity
!align=left {{table_heading_style}} |Regulation/Activity
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!align=left {{table_heading_style}} |Quick Links
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[[File:porteco.png|link=http://porteco.org/AjaxSearch.jsp?searchString=lepB&s=search]] [[File:EcoCyc.gif|link=http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=EG10530]] [[File:regulondb.jpg|link=http://regulondb.ccg.unam.mx/gene?term=ECK120000523&organism=ECK12&format=jsp&type=gene ]] <br/><br/> [[File:dnadisplay.png|link=http://ecoliwiki.net/tools/display_dna.php?gene=lepB&loc=MG1655%3A2703331..2702357,W3110%3A2703965..2702991,REL606%3A2626802..2625828,DH10B%3A2795096..2794122,BW2952%3A2588162..2589136]] [[File:proteindisplay.png|link=http://ecoliwiki.net/tools/display_protein.php?f=NC_000913&start=2588162&end=2589136&gene=lepB&aa=manmfalilviatlvtgilwcvdkfffapkrrerqaaaqaaagdsldkatlkkvapkpgwletgasvfpvlaivlivrsfiyepfqipsgsmmptlligdfilvekfaygikdpiyqktlietghpkrgdivvfkypedpkldyikravglpgdkvtydpvskeltiqpgcssgqacenalpvtysnvepsdfvqtfsrrnggeatsgffevpknetkengirlserketlgdvthriltvpiaqdqvgmyyqqpgqqlatwivppgqyfmmgdnrdnsadsrywgfvpeanlvgrataiwmsfdkqegewptglrlsriggih]]&nbsp;&nbsp;  [[File:pubmed.jpg|link=http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Search&Term=lepB+AND+escherichia+coli]]&nbsp;&nbsp;  [[File:textpresso.jpg|link=http://textpresso.tamu.edu/cgi-bin/textpresso/search?q=lepB]]&nbsp;&nbsp;
 
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==Notes==
===Notes===
{{BacktoTop}}
 
LepB has a blocked N-terminus. False positive lipoprotein prediction, shown to have no signal peptide. Targetted by SRP/FtsY to Sec/YidC for membrane insertion.<ref name='LIB:EcoGene'/>
 




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==References==
==References==
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<references/>
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Latest revision as of 21:48, 27 May 2013

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
References Suggestions
Standard Name

lepB

Gene Synonym(s)

ECK2566, b2568, JW2552, lep[1], lep

Product Desc.

leader peptidase (signal peptidase I)[2][3]

Signal peptidase I; SPI; responsible for type I signal cleavages of periplasmic, OM, some IM, and extracellular proteins[4]

Product Synonyms(s)

leader peptidase (signal peptidase I)[1], B2568[2][1], Lep[2][1], LepB[2][1], LP1[2][1] , ECK2566, JW2552, lep, b2568

Function from GO

<GO_nr />

Knock-Out Phenotype
Regulation/Expression

transcription unit(s): lepAB[2]

Regulation/Activity
Quick Links



        

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See Help:Quickview for help with entering information in the Quickview table.

Notes

[back to top]


LepB has a blocked N-terminus. False positive lipoprotein prediction, shown to have no signal peptide. Targetted by SRP/FtsY to Sec/YidC for membrane insertion.[4]



References

[back to top]


  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
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