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{{Tab On|Quickview|tonB}}{{Tab|Gene|tonB}}{{Tab|Gene Product(s)|tonB}}{{Tab|Expression|tonB}}{{Tab|Evolution|tonB}}{{Tab|On One Page|tonB}}{{TabsBottom}}
{{Tab On|Quickview|tonB}}{{Tab|Gene|tonB}}{{Tab|Gene Product(s)|tonB}}{{Tab|Expression|tonB}}{{Tab|Evolution|tonB}}{{Tab|On One Page|tonB}}{{TabsBottom}}
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{|   id="M49b026dbc6f2f"  class=" tableEdit New_Quickview_Table" 
 
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!{{table_heading_style}} |Gene Name
!align=left {{table_heading_style}} |Standard Name
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[[tonB:Gene|''tonB]]'' (synonyms: ''ECK1246, b1252, JW5195, T1rec, exbA'')<ref name='LIB:Riley_2006'/>
''tonB''
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!{{table_heading_style}} |Product(s)  
!align=left {{table_heading_style}} |Gene Synonym(s)
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[[tonB:Gene_Product(s)|TonB product]]<ref name='LIB:Riley_2006'/>: membrane spanning protein in TonB-ExbB-ExbD complex product, B1252 product, ExbA product
''ECK1246, b1252, JW5195, T1rec, exbA''<ref name='LIB:Riley_2006'/>, exbA''
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!{{table_heading_style}} |Description
!align=left {{table_heading_style}} |Product Desc.
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TonB protein; energy transducer; uptake of iron, cyanocobalimin; sensitivity to phages, colicins<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>  
TonB protein; energy transducer; uptake of iron, cyanocobalimin; sensitivity to phages, colicins<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>;


Component of [[:Category:Complex:TonB energy transducing system|TonB energy transducing system]]<ref name='LIB:EcoCyc11.1'/>,[[:Category:Complex:Outer Membrane Ferric Citrate Transport System|Outer Membrane Ferric Citrate Transport System]]<ref name='LIB:EcoCyc11.1'/>,[[:Category:Complex:Outer Membrane Ferrichrome Transport System|Outer Membrane Ferrichrome Transport System]]<ref name='LIB:EcoCyc11.1'/>,[[:Category:Complex:Outer Membrane Ferric Enterobactin Transport System|Outer Membrane Ferric Enterobactin Transport System]]<ref name='LIB:EcoCyc11.1'/>,[[:Category:Complex:vitamin B12 outer membrane transport complex|vitamin B12 outer membrane transport complex]]<ref name='LIB:EcoCyc11.1'/>,[[:Category:Complex:ferric dicitrate uptake system|ferric dicitrate uptake system]]<ref name='LIB:EcoCyc11.1'/>,[[:Category:Complex:ferrichrome uptake system|ferrichrome uptake system]]<ref name='LIB:EcoCyc11.1'/>,[[:Category:Complex:Ferric Enterobactin Transport System|Ferric Enterobactin Transport System]]<ref name='LIB:EcoCyc11.1'/>,[[:Category:Complex:vitamin B12 transport system|vitamin B12 transport system]]<ref name='LIB:EcoCyc11.1'/>
Component of [[:Category:Complex:TonB energy transducing system|TonB energy transducing system]]<ref name='LIB:EcoCyc11.1'/>; [[:Category:Complex:Outer Membrane Ferric Citrate Transport System|Outer Membrane Ferric Citrate Transport System]]<ref name='LIB:EcoCyc11.1'/>; [[:Category:Complex:Outer Membrane Ferrichrome Transport System|Outer Membrane Ferrichrome Transport System]]<ref name='LIB:EcoCyc11.1'/>; [[:Category:Complex:Outer Membrane Ferric Enterobactin Transport System|Outer Membrane Ferric Enterobactin Transport System]]<ref name='LIB:EcoCyc11.1'/>; [[:Category:Complex:vitamin B12 outer membrane transport complex|vitamin B12 outer membrane transport complex]]<ref name='LIB:EcoCyc11.1'/>; [[:Category:Complex:ferric dicitrate uptake system|ferric dicitrate uptake system]]<ref name='LIB:EcoCyc11.1'/>; [[:Category:Complex:ferrichrome uptake system|ferrichrome uptake system]]<ref name='LIB:EcoCyc11.1'/>; [[:Category:Complex:Ferric Enterobactin Transport System|Ferric Enterobactin Transport System]]<ref name='LIB:EcoCyc11.1'/>; [[:Category:Complex:vitamin B12 transport system|vitamin B12 transport system]]<ref name='LIB:EcoCyc11.1'/>


Uptake of chelated Fe(2+) and cyanocobalamin; works in conjunction with OM receptors; energy transducer; sensitivity to T1, phi80, and colicins; forms a complex with ExbB and ExbD<ref name='LIB:EcoGene'/>
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!align=left {{table_heading_style}} |Product Synonyms(s)
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''membrane spanning protein in TonB-ExbB-ExbD complex<ref name='LIB:Riley_2006'/>, B1252<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, ExbA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, TonB<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/> , ECK1246, exbA, JW5195, T1rec, b1252''
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!align=left {{table_heading_style}} |Function from GO
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<GO_nr />
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!{{table_heading_style}} |Knock-Out Phenotype
!align=left {{table_heading_style}} |Knock-Out Phenotype
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|-
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!{{table_heading_style}} |Regulation/Expression
!align=left {{table_heading_style}} |Regulation/Expression
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transcription unit(s): [[:Category:Txn_unit:tonB|tonB]]<ref name='LIB:EcoCyc10.6'/>, OP00228  
transcription unit(s): [[:Category:Txn_unit:tonB|tonB]]<ref name='LIB:EcoCyc10.6'/>, OP00228  
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!{{table_heading_style}} |Regulation/Activity
!align=left {{table_heading_style}} |Regulation/Activity
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!align=left {{table_heading_style}} |Quick Links
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[[File:porteco.png|link=http://porteco.org/AjaxSearch.jsp?searchString=tonB&s=search]] [[File:EcoCyc.gif|link=http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=EG11012]] [[File:regulondb.jpg|link=http://regulondb.ccg.unam.mx/gene?term=ECK120001001&organism=ECK12&format=jsp&type=gene ]] <br/><br/> [[File:dnadisplay.png|link=http://ecoliwiki.net/tools/display_dna.php?gene=tonB&loc=MG1655%3A1309113..1309832,W3110%3A1312803..1313522,DH10B%3A1398509..1399228,REL606%3A1308683..1309402,BW2952%3A1199962..1200681]] [[File:proteindisplay.png|link=http://ecoliwiki.net/tools/display_protein.php?f=NC_000913&start=1199962&end=1200681&gene=tonB&aa=mtldlprrfpwptllsvcihgavvagllytsvhqvielpapaqpisvtmvtpadleppqavqpppepvvepepepepipeppkeapvviekpkpkpkpkpkpvkkvqeqpkrdvkpvesrpaspfentaparltsstataatskpvtsvasgpralsrnqpqyparaqalriegqvkvkfdvtpdgrvdnvqilsakpanmferevknamrrwryepgkpgsgivvnilfkingtteiq]]&nbsp;&nbsp;  [[File:pubmed.jpg|link=http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Search&Term=tonB+AND+escherichia+coli]]&nbsp;&nbsp;  [[File:textpresso.jpg|link=http://textpresso.tamu.edu/cgi-bin/textpresso/search?q=tonB]]&nbsp;&nbsp;
 
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==Notes==
===Notes===
{{BacktoTop}}
 
Periplasmic TonB is anchored to the cytoplasmic membrane by a signal anchor and interacts with outer membrane proteins, thus TonB spans the periplasmic space.  TonB contains 40 proline residues (17%).<ref name='LIB:EcoGene'/>
 




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==References==
==References==
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Latest revision as of 21:45, 27 May 2013

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
References Suggestions
Standard Name

tonB

Gene Synonym(s)

ECK1246, b1252, JW5195, T1rec, exbA[1], exbA

Product Desc.

TonB protein; energy transducer; uptake of iron, cyanocobalimin; sensitivity to phages, colicins[2][3];

Component of TonB energy transducing system[3]; Outer Membrane Ferric Citrate Transport System[3]; Outer Membrane Ferrichrome Transport System[3]; Outer Membrane Ferric Enterobactin Transport System[3]; vitamin B12 outer membrane transport complex[3]; ferric dicitrate uptake system[3]; ferrichrome uptake system[3]; Ferric Enterobactin Transport System[3]; vitamin B12 transport system[3]

Uptake of chelated Fe(2+) and cyanocobalamin; works in conjunction with OM receptors; energy transducer; sensitivity to T1, phi80, and colicins; forms a complex with ExbB and ExbD[4]

Product Synonyms(s)

membrane spanning protein in TonB-ExbB-ExbD complex[1], B1252[2][1], ExbA[2][1], TonB[2][1] , ECK1246, exbA, JW5195, T1rec, b1252

Function from GO

<GO_nr />

Knock-Out Phenotype
Regulation/Expression

transcription unit(s): tonB[2], OP00228

Regulation/Activity
Quick Links



        

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Notes

[back to top]


Periplasmic TonB is anchored to the cytoplasmic membrane by a signal anchor and interacts with outer membrane proteins, thus TonB spans the periplasmic space. TonB contains 40 proline residues (17%).[4]



References

[back to top]


  1. ↑ 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.00 3.01 3.02 3.03 3.04 3.05 3.06 3.07 3.08 3.09 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
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