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{{Tab On|Quickview|nrdA}}{{Tab|Gene|nrdA}}{{Tab|Gene Product(s)|nrdA}}{{Tab|Expression|nrdA}}{{Tab|Evolution|nrdA}}{{Tab|On One Page|nrdA}}{{TabsBottom}}
{{Tab On|Quickview|nrdA}}{{Tab|Gene|nrdA}}{{Tab|Gene Product(s)|nrdA}}{{Tab|Expression|nrdA}}{{Tab|Evolution|nrdA}}{{Tab|On One Page|nrdA}}{{TabsBottom}}
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!{{table_heading_style}} |Gene Name
!align=left {{table_heading_style}} |Standard Name
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[[nrdA:Gene|''nrdA]]'' (synonyms: ''ECK2226, b2234, JW2228, dnaF'')<ref name='LIB:Riley_2006'/>
''nrdA''
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!{{table_heading_style}} |Product(s)  
!align=left {{table_heading_style}} |Gene Synonym(s)
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[[nrdA:Gene_Product(s)|NrdA product]]<ref name='LIB:Riley_2006'/>: ribonucleoside diphosphate reductase 1, alpha subunit<ref name='LIB:Riley_2006'/>, B2234<ref name='LIB:EcoCyc10.6'/>, DnaF<ref name='LIB:EcoCyc10.6'/>, NrdA<ref name='LIB:EcoCyc10.6'/>, [[:Category:Complex:B1 protein|B1 protein]]<ref name='LIB:EcoCyc10.6'/>, [[:Category:Complex:ribonucleotide reductase I|ribonucleotide reductase I]]<ref name='LIB:EcoCyc10.6'/>
''ECK2226, b2234, JW2228, dnaF''<ref name='LIB:Riley_2006'/>, dnaF''
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!{{table_heading_style}} |Description
!align=left {{table_heading_style}} |Product Desc.
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NrdA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>
NrdA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>;


Component of [[:Category:Complex:B1 protein|B1 protein]]<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>; [[:Category:Complex:ribonucleotide reductase I|ribonucleotide reductase I]]<ref name='LIB:EcoCyc10.6'/>


Ribonucleoside diphosphate reductase, subunit alpha; class I, aerobic; ribonucleotide reductase; B1 protein, R1 subunit<ref name='LIB:EcoGene'/>
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!align=left {{table_heading_style}} |Product Synonyms(s)
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''ribonucleoside diphosphate reductase 1, alpha subunit<ref name='LIB:Riley_2006'/>, B2234<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, DnaF<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, NrdA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/> , dnaF, ECK2226, JW2228, b2234''
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!align=left {{table_heading_style}} |Function from GO
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<GO_nr />
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!{{table_heading_style}} |Knock-Out Phenotype
!align=left {{table_heading_style}} |Knock-Out Phenotype
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!{{table_heading_style}} |Regulation/Expression
!align=left {{table_heading_style}} |Regulation/Expression
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transcription unit(s): [[:Category:txn_units:nrdAB|nrdAB]]<ref name='LIB:EcoCyc10.6'/>, OP00063, nrd, nrdA  
transcription unit(s): [[:Category:Txn_unit:nrdAB|nrdAB]]<ref name='LIB:EcoCyc10.6'/>, OP00063, nrd, nrdA  
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!{{table_heading_style}} |Regulation/Activity
!align=left {{table_heading_style}} |Regulation/Activity
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[[File:porteco.png|link=http://porteco.org/AjaxSearch.jsp?searchString=nrdA&s=search]] [[File:EcoCyc.gif|link=http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=EG10660]] [[File:regulondb.jpg|link=http://regulondb.ccg.unam.mx/gene?term=ECK120000653&organism=ECK12&format=jsp&type=gene ]] <br/><br/> [[File:dnadisplay.png|link=http://ecoliwiki.net/tools/display_dna.php?gene=nrdA&loc=MG1655%3A2342887..2345172,W3110%3A2349535..2351820,DH10B%3A2433875..2436160,REL606%3A2291565..2293850,BW2952%3A2228692..2230977]] [[File:proteindisplay.png|link=http://ecoliwiki.net/tools/display_protein.php?f=NC_000913&start=2228692&end=2230977&gene=nrdA&aa=mnqnllvtkrdgsterinldkihrvldwaaeglhnvsisqvelrshiqfydgiktsdihetiikaaadlisrdapdyqylaarlaifhlrkkaygqfeppalydhvvkmvemgkydnhlledyteeefkqmdtfidhdrdmtfsyaavkqlegkylvqnrvtgeiyesaqflyilvaaclfsnypretrlqyvkrfydavstfkislptpimsgvrtptrqfsscvliecgdsldsinatssaivkyvsqragiginagriralgspirggeafhtgcipfykhfqtavkscsqggvrggaatlfypmwhlevesllvlknnrgvegnrvrhmdygvqinklmytrllkgeditlfspsdvpglydaffadqeeferlytkyekddsirkqrvkavelfslmmqerastgriyiqnvdhcnthspfdpaiapvrqsnlcleialptkplndvndengeialctlsafnlgainnldeleelailavraldalldyqdypipaakrgamgrrtlgigvinfayylakhgkrysdgsannlthktfeaiqyyllkasnelakeqgacpwfnettyakgilpidtykkdldtianeplhydwealresikthglrnstlsalmpsetssqisnatngiepprgyvsikaskdgilrqvvpdyehlhdayellwempgndgylqlvgimqkfidqsisantnydpsrfpsgkvpmqqllkdlltaykfgvktlyyqntrdgaedaqddlvpsiqddgcesgacki]]&nbsp;&nbsp;  [[File:pubmed.jpg|link=http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Search&Term=nrdA+AND+escherichia+coli]]&nbsp;&nbsp;  [[File:textpresso.jpg|link=http://textpresso.tamu.edu/cgi-bin/textpresso/search?q=nrdA]]&nbsp;&nbsp;
 
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==Notes==
===Notes===
{{BacktoTop}}
 
Reducing equivalents provided by glutaredoxin or thioredoxin.  Binds TrxA (Kumar, 2004). About half of the overproduced protein has the first one or two amino acids removed. E. coli B native protein is reported to start with Gln. a second native E. coli B protein start may correspond to a cleavage after Leu26. Leu26 CTG codon is unlikely to be an alternative start codon in K-12 or B and no evidence of this cleavage or an alternative start codon was seen with the overproduced K-12 protein.  An M-N or MN-Q cleavage by MAP would be unusual. The variable N-termini may be created by an unknown protease.<ref name='LIB:EcoGene'/>
 




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==References==
==References==
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Latest revision as of 21:47, 27 May 2013

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
References Suggestions
Standard Name

nrdA

Gene Synonym(s)

ECK2226, b2234, JW2228, dnaF[1], dnaF

Product Desc.

NrdA[2][3];

Component of B1 protein[2][3]; ribonucleotide reductase I[2]

Ribonucleoside diphosphate reductase, subunit alpha; class I, aerobic; ribonucleotide reductase; B1 protein, R1 subunit[4]

Product Synonyms(s)

ribonucleoside diphosphate reductase 1, alpha subunit[1], B2234[2][1], DnaF[2][1], NrdA[2][1] , dnaF, ECK2226, JW2228, b2234

Function from GO

<GO_nr />

Knock-Out Phenotype
Regulation/Expression

transcription unit(s): nrdAB[2], OP00063, nrd, nrdA

Regulation/Activity
Quick Links



        

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Notes

[back to top]


Reducing equivalents provided by glutaredoxin or thioredoxin. Binds TrxA (Kumar, 2004). About half of the overproduced protein has the first one or two amino acids removed. E. coli B native protein is reported to start with Gln. a second native E. coli B protein start may correspond to a cleavage after Leu26. Leu26 CTG codon is unlikely to be an alternative start codon in K-12 or B and no evidence of this cleavage or an alternative start codon was seen with the overproduced K-12 protein. An M-N or MN-Q cleavage by MAP would be unusual. The variable N-termini may be created by an unknown protease.[4]



References

[back to top]


  1. ↑ 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
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