lepA:Quickview: Difference between revisions

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!align=left {{table_heading_style}} |Standard Name
!align=left {{table_heading_style}} |Standard Name
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''lepA''
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!align=left {{table_heading_style}} |Gene Synonym(s)
!align=left {{table_heading_style}} |Gene Synonym(s)
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''ECK2567, b2569, JW2553''<ref name='LIB:Riley_2006'/>, JW2553''
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!align=left {{table_heading_style}} |Product Desc.
!align=left {{table_heading_style}} |Product Desc.
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GTP-binding membrane protein<ref name='LIB:EcoCyc10.6'/>; elongation factor 4<ref name='LIB:EcoCyc11.1'/>
Back-translocating Elongation Factor EF4, GTPase; required for efficient and accurate protein synthesis<ref name='LIB:EcoGene'/>
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!align=left {{table_heading_style}} |Product Synonyms(s)
!align=left {{table_heading_style}} |Product Synonyms(s)
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''GTP-binding membrane protein<ref name='LIB:Riley_2006'/>, B2569<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, LepA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, EF4<ref name='LIB:EcoCyc11.1'/><ref name='LIB:Riley_2006'/> , ECK2567, JW2553, b2569''
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!align=left {{table_heading_style}} |Function from GO
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<GO_nr />
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!align=left {{table_heading_style}} |Knock-Out Phenotype
!align=left {{table_heading_style}} |Knock-Out Phenotype
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!align=left {{table_heading_style}} |Regulation/Expression
!align=left {{table_heading_style}} |Regulation/Expression
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transcription unit(s): [[:Category:Txn_unit:lepAB|lepAB]]<ref name='LIB:EcoCyc10.6'/>
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!align=left {{table_heading_style}} |Regulation/Activity
!align=left {{table_heading_style}} |Regulation/Activity
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!align=left {{table_heading_style}} |Quick Links
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[[File:porteco.png|link=http://porteco.org/AjaxSearch.jsp?searchString=lepA&s=search]] [[File:EcoCyc.gif|link=http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=EG10529]] [[File:regulondb.jpg|link=http://regulondb.ccg.unam.mx/gene?term=ECK120000522&organism=ECK12&format=jsp&type=gene ]] <br/><br/> [[File:dnadisplay.png|link=http://ecoliwiki.net/tools/display_dna.php?gene=lepA&loc=MG1655%3A2705146..2703347,W3110%3A2705780..2703981,REL606%3A2628617..2626818,DH10B%3A2796911..2795112,BW2952%3A2589152..2590951]] [[File:proteindisplay.png|link=http://ecoliwiki.net/tools/display_protein.php?f=NC_000913&start=2589152&end=2590951&gene=lepA&aa=mknirnfsiiahidhgkstlsdriiqicgglsdremeaqvldsmdlerergitikaqsvtldykasdgetyqlnfidtpghvdfsyevsrslaacegallvvdagqgveaqtlancytamemdlevvpvlnkidlpaadpervaeeiedivgidatdavrcsaktgvgvqdvlerlvrdipppegdpegplqaliidswfdnylgvvslirikngtlrkgdkvkvmstgqtynadrlgiftpkqvdrtelkcgevgwlvcaikdihgapvgdtltlarnpaekalpgfkkvkpqvyaglfpvssddyeafrdalgklslndaslfyepesssalgfgfrcgflgllhmeiiqerlereydldlittaptvvyevettsreviyvdspsklpavnniyelrepiaechmllpqaylgnvitlcvekrgvqtnmvyhgnqvaltyeipmaevvldffdrlkstsrgyasldynfkrfqasdmvrvdvlingervdalalithrdnsqnrgrelvekmkdliprqqfdiaiqaaigthiiarstvkqlrknvlakcyggdisrkkkllqkqkegkkrmkqignvelpqeaflailhvgkdnk]]&nbsp;&nbsp;  [[File:pubmed.jpg|link=http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Search&Term=lepA+AND+escherichia+coli]]&nbsp;&nbsp;  [[File:textpresso.jpg|link=http://textpresso.tamu.edu/cgi-bin/textpresso/search?q=lepA]]&nbsp;&nbsp;


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Latest revision as of 21:48, 27 May 2013

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
References Suggestions
Standard Name

lepA

Gene Synonym(s)

ECK2567, b2569, JW2553[1], JW2553

Product Desc.

GTP-binding membrane protein[2]; elongation factor 4[3]

Back-translocating Elongation Factor EF4, GTPase; required for efficient and accurate protein synthesis[4]

Product Synonyms(s)

GTP-binding membrane protein[1], B2569[2][1], LepA[2][1], EF4[3][1] , ECK2567, JW2553, b2569

Function from GO

<GO_nr />

Knock-Out Phenotype
Regulation/Expression

transcription unit(s): lepAB[2]

Regulation/Activity
Quick Links



        

See Help:Quickview for help with entering information in the Quickview table.

Notes

[back to top]


Although EF4 improves translational accuracy, it can not reverse paromomycin-induced errors (Qin, 2006). EF4 is a widely conserved protein, the first four domains are related to EF-G domains I, II, III, and V (Qin, 2006). EF4 overexpression is toxic (Qin 2006). EF4 (LepA) is in the lepAB operon but has no known role in signal peptidase I (LepB) activity.[4]



References

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  1. ↑ 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.