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{{Tab On|Quickview|add}}{{Tab|Gene|add}}{{Tab|Gene Product(s)|add}}{{Tab|Expression|add}}{{Tab|Evolution|add}}{{Tab|On One Page|add}}{{TabsBottom}}
{{Tab On|Quickview|add}}{{Tab|Gene|add}}{{Tab|Gene Product(s)|add}}{{Tab|Expression|add}}{{Tab|Evolution|add}}{{Tab|On One Page|add}}{{TabsBottom}}
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!{{table_heading_style}} |Gene Name
!align=left {{table_heading_style}} |Standard Name
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[[add:Gene|''add]]'' (synonyms: ''ECK1618, b1623, JW1615'')<ref name='LIB:Riley_2006'/>
''add''
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!{{table_heading_style}} |Product(s)  
!align=left {{table_heading_style}} |Gene Synonym(s)
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[[add:Gene_Product(s)|Add product]]<ref name='LIB:Riley_2006'/>: adenosine deaminase<ref name='LIB:Riley_2006'/>, B1623<ref name='LIB:EcoCyc10.6'/>, Add<ref name='LIB:EcoCyc10.6'/>
''ECK1618, b1623, JW1615''<ref name='LIB:Riley_2006'/>, JW1615''
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!{{table_heading_style}} |Description
!align=left {{table_heading_style}} |Product Desc.
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ADENODEAMIN-MONOMER<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>
 


Adenosine deaminase; mutants affect growth on deoxyadenosine in purA, B mutants<ref name='LIB:EcoGene'/>
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!align=left {{table_heading_style}} |Product Synonyms(s)
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''adenosine deaminase<ref name='LIB:Riley_2006'/>, B1623<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, Add<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/> , ECK1618, JW1615, b1623''
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!align=left {{table_heading_style}} |Function from GO
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<GO_nr />
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!{{table_heading_style}} |Knock-Out Phenotype
!align=left {{table_heading_style}} |Knock-Out Phenotype
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!{{table_heading_style}} |Regulation/Expression
!align=left {{table_heading_style}} |Regulation/Expression
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transcription unit(s): [[:Category:txn_units:add|add]]<ref name='LIB:EcoCyc10.6'/>  
transcription unit(s): [[:Category:Txn_unit:add|add]]<ref name='LIB:EcoCyc10.6'/>  
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!{{table_heading_style}} |Regulation/Activity
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[[File:porteco.png|link=http://porteco.org/AjaxSearch.jsp?searchString=add&s=search]] [[File:EcoCyc.gif|link=http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=EG10030]] [[File:regulondb.jpg|link=http://regulondb.ccg.unam.mx/gene?term=ECK120000027&organism=ECK12&format=jsp&type=gene ]] <br/><br/> [[File:dnadisplay.png|link=http://ecoliwiki.net/tools/display_dna.php?gene=add&loc=MG1655%3A1700257..1701258,W3110%3A1703947..1704948,DH10B%3A1791218..1792219,REL606%3A1679427..1680428,BW2952%3A1592316..1593317]] [[File:proteindisplay.png|link=http://ecoliwiki.net/tools/display_protein.php?f=NC_000913&start=1592316&end=1593317&gene=add&aa=midttlpltdihrhldgnirpqtilelgrqynislpaqsletliphvqvianepdlvsfltkldwgvkvlasldacrrvafeniedaarhglhyvelrfspgymamahqlpvagvveavidgvregcrtfgvqakligimsrtfgeaacqqeleaflahrdqitaldlagdelgfpgslflshfnrardagwhitvhageaagpesiwqairelgaerighgvkaiedralmdflaeqqigiescltsniqtstvaelaahplktflehgirasintddpgvqgvdiiheytvaapaaglsreqirqaqinglemaflsaeekralrekvaak]]&nbsp;&nbsp;  [[File:pubmed.jpg|link=http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Search&Term=add+AND+escherichia+coli]]&nbsp;&nbsp;  [[File:textpresso.jpg|link=http://textpresso.tamu.edu/cgi-bin/textpresso/search?q=add]]&nbsp;&nbsp;
 
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==Notes==
===Notes===
{{BacktoTop}}
 
Adenosine deaminase is an enzyme involved in purine metabolism, which irreversibly deaminates both adenosine and deoxyadenosine to inosine and deoxyinosine. The optimal pH for this enzyme is around 7.5-8, but activity is irreversibly lost when pH is lower than 2.7 or higher than 9.5. Adenosine deaminase is sensitive to heavy metals, such as Ag+, Cu2+, and Cr3+, and reacts with them irreversibly (Koch, 1958). <ref name='PMID:13654350'/>
 
Complications in purine metabolism often result in various disorders in humans. Deficiencies amounts of adenosine deaminase result in diseases such as severe combined immunodeficiency disorder (SCID) and lymphopenia.
 
Binds TrxA (Kumar, 2004).<ref name='LIB:EcoGene'/>
 




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==References==
==References==
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Latest revision as of 21:53, 27 May 2013

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
References Suggestions
Standard Name

add

Gene Synonym(s)

ECK1618, b1623, JW1615[1], JW1615

Product Desc.

Adenosine deaminase; mutants affect growth on deoxyadenosine in purA, B mutants[2]

Product Synonyms(s)

adenosine deaminase[1], B1623[3][1], Add[3][1] , ECK1618, JW1615, b1623

Function from GO

<GO_nr />

Knock-Out Phenotype
Regulation/Expression

transcription unit(s): add[3]

Regulation/Activity
Quick Links



        

edit table

See Help:Quickview for help with entering information in the Quickview table.

Notes

[back to top]


Adenosine deaminase is an enzyme involved in purine metabolism, which irreversibly deaminates both adenosine and deoxyadenosine to inosine and deoxyinosine. The optimal pH for this enzyme is around 7.5-8, but activity is irreversibly lost when pH is lower than 2.7 or higher than 9.5. Adenosine deaminase is sensitive to heavy metals, such as Ag+, Cu2+, and Cr3+, and reacts with them irreversibly (Koch, 1958). [4]

Complications in purine metabolism often result in various disorders in humans. Deficiencies amounts of adenosine deaminase result in diseases such as severe combined immunodeficiency disorder (SCID) and lymphopenia.

Binds TrxA (Kumar, 2004).[2]



References

[back to top]


  1. ↑ 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  3. ↑ 3.0 3.1 3.2 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ KOCH, AL & VALLEE, G (1959) The properties of adenosine deaminase and adenosine nucleoside phosphorylase in extracts of Escherichia coli. J. Biol. Chem. 234 1213-8 PubMed


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