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{{Tab On|Quickview|marA}}{{Tab|Gene|marA}}{{Tab|Gene Product(s)|marA}}{{Tab|Expression|marA}}{{Tab|Evolution|marA}}{{Tab|On One Page|marA}}{{TabsBottom}}
{{Tab On|Quickview|marA}}{{Tab|Gene|marA}}{{Tab|Gene Product(s)|marA}}{{Tab|Expression|marA}}{{Tab|Evolution|marA}}{{Tab|On One Page|marA}}{{TabsBottom}}
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!{{table_heading_style}} |Gene Name
!align=left {{table_heading_style}} |Standard Name
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[[marA:Gene|''marA]]'' (synonyms: ''ECK1524, b1531, JW5249, cfxB, norB, soxQ, inaR, nfxC'')<ref name='LIB:Riley_2006'/>
''marA''
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!{{table_heading_style}} |Product(s)  
!align=left {{table_heading_style}} |Gene Synonym(s)
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[[marA:Gene_Product(s)|MarA product]]<ref name='LIB:Riley_2006'/>: DNA-binding transcriptional dual activator of multiple antibiotic resistance<ref name='LIB:Riley_2006'/>, B1531<ref name='LIB:EcoCyc10.6'/>, CfxB<ref name='LIB:EcoCyc10.6'/>, InaR<ref name='LIB:EcoCyc10.6'/>, NorB<ref name='LIB:EcoCyc10.6'/>, SoxQ<ref name='LIB:EcoCyc10.6'/>, NfxC<ref name='LIB:EcoCyc10.6'/>, MarA<ref name='LIB:EcoCyc10.6'/>
''ECK1524, b1531, JW5249, cfxB, norB, soxQ, inaR, nfxC''<ref name='LIB:Riley_2006'/>, nfxC''
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!{{table_heading_style}} |Description
!align=left {{table_heading_style}} |Product Desc.
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MarA transcriptional activator<ref name='LIB:EcoCyc10.6'/>MarA transcriptional dual regulator<ref name='LIB:EcoCyc11.1'/>
MarA transcriptional activator<ref name='LIB:EcoCyc10.6'/>; MarA transcriptional dual regulator<ref name='LIB:EcoCyc11.1'/>
 


Transcriptional activator for multiple antibiotic resistance; AraC family; resistance to tetracycline, chloramphenicol<ref name='LIB:EcoGene'/>
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!align=left {{table_heading_style}} |Product Synonyms(s)
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''DNA-binding transcriptional dual activator of multiple antibiotic resistance<ref name='LIB:Riley_2006'/>, B1531<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, CfxB<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, InaR<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, NorB<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, SoxQ<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, NfxC<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, MarA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/> , cfxB, ECK1524, inaR, JW5249, nfxC, norB, soxQ, b1531''
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!align=left {{table_heading_style}} |Function from GO
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<GO_nr />
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!{{table_heading_style}} |Knock-Out Phenotype
!align=left {{table_heading_style}} |Knock-Out Phenotype
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!{{table_heading_style}} |Regulation/Expression
!align=left {{table_heading_style}} |Regulation/Expression
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transcription unit(s): [[:Category:txn_units:marRAB|marRAB]]<ref name='LIB:EcoCyc10.6'/>, OP00264  
transcription unit(s): [[:Category:Txn_unit:marRAB|marRAB]]<ref name='LIB:EcoCyc10.6'/>, OP00264  
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!{{table_heading_style}} |Regulation/Activity
!align=left {{table_heading_style}} |Regulation/Activity
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[[File:porteco.png|link=http://porteco.org/AjaxSearch.jsp?searchString=marA&s=search]] [[File:EcoCyc.gif|link=http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=EG11434]] [[File:regulondb.jpg|link=http://regulondb.ccg.unam.mx/gene?term=ECK120001398&organism=ECK12&format=jsp&type=gene ]] <br/><br/> [[File:dnadisplay.png|link=http://ecoliwiki.net/tools/display_dna.php?gene=marA&loc=MG1655%3A1617598..1617981,W3110%3A1621288..1621671,DH10B%3A1707223..1707606,REL606%3A1587340..1587723,BW2952%3A1509657..1510040]] [[File:proteindisplay.png|link=http://ecoliwiki.net/tools/display_protein.php?f=NC_000913&start=1509657&end=1510040&gene=marA&aa=mtmsrrntdaitihsildwiednlesplslekvsersgyskwhlqrmfkketghslgqyirsrkmteiaqklkesnepilylaerygfesqqtltrtfknyfdvpphkyrmtnmqgesrflhplnhyns]]&nbsp;&nbsp;  [[File:pubmed.jpg|link=http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Search&Term=marA+AND+escherichia+coli]]&nbsp;&nbsp;  [[File:textpresso.jpg|link=http://textpresso.tamu.edu/cgi-bin/textpresso/search?q=marA]]&nbsp;&nbsp;
 
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==Notes==
===Notes===
{{BacktoTop}}
 
Martin (2002) provide some evidence in support of the this alternative ATG start: native protein is slightly smaller than the engineered protein by Western blot. The spacing to the GAGG RBS is bad for the first ATG and excellent for the second ATG. MarA is unstable.<ref name='LIB:EcoGene'/>
 




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==References==
==References==
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Latest revision as of 21:48, 27 May 2013

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
References Suggestions
Standard Name

marA

Gene Synonym(s)

ECK1524, b1531, JW5249, cfxB, norB, soxQ, inaR, nfxC[1], nfxC

Product Desc.

MarA transcriptional activator[2]; MarA transcriptional dual regulator[3]

Transcriptional activator for multiple antibiotic resistance; AraC family; resistance to tetracycline, chloramphenicol[4]

Product Synonyms(s)

DNA-binding transcriptional dual activator of multiple antibiotic resistance[1], B1531[2][1], CfxB[2][1], InaR[2][1], NorB[2][1], SoxQ[2][1], NfxC[2][1], MarA[2][1] , cfxB, ECK1524, inaR, JW5249, nfxC, norB, soxQ, b1531

Function from GO

<GO_nr />

Knock-Out Phenotype
Regulation/Expression

transcription unit(s): marRAB[2], OP00264

Regulation/Activity
Quick Links



        

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Notes

[back to top]


Martin (2002) provide some evidence in support of the this alternative ATG start: native protein is slightly smaller than the engineered protein by Western blot. The spacing to the GAGG RBS is bad for the first ATG and excellent for the second ATG. MarA is unstable.[4]



References

[back to top]


  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
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