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{{Tab On|Quickview|maeA}}{{Tab|Gene|maeA}}{{Tab|Gene Product(s)|maeA}}{{Tab|Expression|maeA}}{{Tab|Evolution|maeA}}{{Tab|On One Page|maeA}}{{TabsBottom}}
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!{{table_heading_style}} |Gene Name
!align=left {{table_heading_style}} |Standard Name
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[[maeA:Gene|''maeA]]'' (synonyms: ''sfcA, ECK1473, b1479, JW5238, mae, maeA?'')<ref name='LIB:Riley_2006'/><ref name='LIB:EcoCyc11.1'/><ref name='LIB:EcoCyc10.6'/>
''maeA''
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!{{table_heading_style}} |Product(s)  
!align=left {{table_heading_style}} |Gene Synonym(s)
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[[maeA:Gene_Product(s)|SfcA product]]<ref name='LIB:Riley_2006'/>: malate dehydrogenase, (decarboxylating, NAD-requiring) (malic enzyme)<ref name='LIB:Riley_2006'/>, B1479<ref name='LIB:EcoCyc10.6'/>, MaeA<ref name='LIB:EcoCyc10.6'/>, SfcA<ref name='LIB:EcoCyc10.6'/>, [[:Category:Complex:malic enzyme, NAD-linked|malic enzyme, NAD-linked]]<ref name='LIB:EcoCyc10.6'/>
''sfcA, ECK1473, b1479, JW5238, mae, maeA?''<ref name='LIB:Riley_2006'/><ref name='LIB:EcoCyc11.1'/><ref name='LIB:EcoCyc10.6'/>
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!{{table_heading_style}} |Description
!align=left {{table_heading_style}} |Product Desc.
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MaeA<ref name='LIB:EcoCyc10.6'/>malate dehydrogenase, NAD-requiring<ref name='LIB:EcoCyc11.1'/>
MaeA<ref name='LIB:EcoCyc10.6'/>; malate dehydrogenase, NAD-requiring<ref name='LIB:EcoCyc11.1'/>;


Component of [[:Category:Complex:malic enzyme, NAD-linked|malic enzyme, NAD-linked]]<ref name='LIB:EcoCyc10.6'/>; [[:Category:Complex:malic enzyme, NAD-linked|malate dehydrogenase, NAD-requiring]]<ref name='LIB:EcoCyc11.1'/>


Malic enzyme, NAD-dependent; NAD-ME<ref name='LIB:EcoGene'/>
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!align=left {{table_heading_style}} |Product Synonyms(s)
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''malate dehydrogenase, (decarboxylating, NAD-requiring) (malic enzyme)<ref name='LIB:Riley_2006'/>, B1479<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, MaeA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, SfcA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/> , ECK1473, JW5238, sfcA, b1479''
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!align=left {{table_heading_style}} |Function from GO
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<GO_nr />
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!{{table_heading_style}} |Knock-Out Phenotype
!align=left {{table_heading_style}} |Knock-Out Phenotype
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!{{table_heading_style}} |Regulation/Expression
!align=left {{table_heading_style}} |Regulation/Expression
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transcription unit(s): [[:Category:txn_units:sfcA|sfcA]]<ref name='LIB:EcoCyc10.6'/>  
transcription unit(s): [[:Category:Txn_unit:sfcA|sfcA]]<ref name='LIB:EcoCyc10.6'/>  
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!{{table_heading_style}} |Regulation/Activity
!align=left {{table_heading_style}} |Regulation/Activity
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[[File:porteco.png|link=http://porteco.org/AjaxSearch.jsp?searchString=maeA&s=search]] [[File:EcoCyc.gif|link=http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=EG10948]] [[File:regulondb.jpg|link=http://regulondb.ccg.unam.mx/gene?term=ECK120000937&organism=ECK12&format=jsp&type=gene ]] <br/><br/> [[File:dnadisplay.png|link=http://ecoliwiki.net/tools/display_dna.php?gene=maeA&loc=MG1655%3A1553693..1551996,W3110%3A1557383..1555686,DH10B%3A1644288..1642591,REL606%3A1527910..1529607,BW2952%3A1444055..1445752]] [[File:proteindisplay.png|link=http://ecoliwiki.net/tools/display_protein.php?f=NC_000913&start=1444055&end=1445752&gene=maeA&aa=mdiqkrvsdmepktkkqrslyipyagpvllefpllnkgsafsmeerrnfnllgllpevvetieeqaerawiqyqgfkteidkhiylrniqdtnetlfyrlvnnhldemmpviytptvgaacerfseiyrrsrgvfisyqnrhnmddilqnvpnhnikvivvtdgerilglgdqgiggmgipigklslytacggispaytlpvvldvgtnnqqllndplymgwrnpritddeyyefvdefiqavkqrwpdvllqfedfaqknampllnryrneicsfnddiqgtaavtvgtliaasraaggqlsekkivflgagsagcgiaemiisqtqreglseeaarqkvfmvdrfglltdkmpnllpfqtklvqkrenlsdwdtdsdvlslldvvrnvkpdiligvsgqtglfteeiiremhkhcprpivmplsnptsrveatpqdiiawtegnalvatgspfnpvvwkdkiypiaqcnnafifpgiglgviasgasritdemlmsasetlaqysplvlngegmvlpelkdiqkvsraiafavgkmaqqqgvavktsaealqqaiddnfwqaeyrdyrrtsi]]&nbsp;&nbsp;  [[File:pubmed.jpg|link=http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Search&Term=maeA+AND+escherichia+coli]]&nbsp;&nbsp;  [[File:textpresso.jpg|link=http://textpresso.tamu.edu/cgi-bin/textpresso/search?q=maeA]]&nbsp;&nbsp;
 
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==Notes==
===Notes===
{{BacktoTop}}
 
MaeA catalyzes four reactions: I, NAD-dependent L-malate decarboxylation; II, NAD-independent oxalacetate decarboxylation; III, oxalacetate reductase, NAD-dependent; !V, pyruvate reductase, NAD-dependent. Acetyl-CoA and ATP are allosteric inhibitors; aspartate is an allosteric activator. Reaction I proceeds by two steps: dehydrogenation, then decarboxylation.<ref name='LIB:EcoGene'/>
 




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==References==
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Latest revision as of 21:48, 27 May 2013

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
References Suggestions
Standard Name

maeA

Gene Synonym(s)

sfcA, ECK1473, b1479, JW5238, mae, maeA?[1][2][3]

Product Desc.

MaeA[3]; malate dehydrogenase, NAD-requiring[2];

Component of malic enzyme, NAD-linked[3]; malate dehydrogenase, NAD-requiring[2]

Malic enzyme, NAD-dependent; NAD-ME[4]

Product Synonyms(s)

malate dehydrogenase, (decarboxylating, NAD-requiring) (malic enzyme)[1], B1479[3][1], MaeA[3][1], SfcA[3][1] , ECK1473, JW5238, sfcA, b1479

Function from GO

<GO_nr />

Knock-Out Phenotype
Regulation/Expression

transcription unit(s): sfcA[3]

Regulation/Activity
Quick Links



        

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Notes

[back to top]


MaeA catalyzes four reactions: I, NAD-dependent L-malate decarboxylation; II, NAD-independent oxalacetate decarboxylation; III, oxalacetate reductase, NAD-dependent; !V, pyruvate reductase, NAD-dependent. Acetyl-CoA and ATP are allosteric inhibitors; aspartate is an allosteric activator. Reaction I proceeds by two steps: dehydrogenation, then decarboxylation.[4]



References

[back to top]


  1. ↑ 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
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