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{{Tab On|Quickview|fadR}}{{Tab|Gene|fadR}}{{Tab|Gene Product(s)|fadR}}{{Tab|Expression|fadR}}{{Tab|Evolution|fadR}}{{Tab|On One Page|fadR}}{{TabsBottom}}
{{Tab On|Quickview|fadR}}{{Tab|Gene|fadR}}{{Tab|Gene Product(s)|fadR}}{{Tab|Expression|fadR}}{{Tab|Evolution|fadR}}{{Tab|On One Page|fadR}}{{TabsBottom}}
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!{{table_heading_style}} |Gene Name
!align=left {{table_heading_style}} |Standard Name
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[[fadR:Gene|''fadR]]'' (synonyms: ''ECK1175, b1187, JW1176, dec, ole, thdB, oleR'')<ref name='LIB:Riley_2006'/>
''fadR''
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!{{table_heading_style}} |Product(s)  
!align=left {{table_heading_style}} |Gene Synonym(s)
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[[fadR:Gene_Product(s)|FadR product]]<ref name='LIB:Riley_2006'/>: DNA-binding transcriptional dual regulator of fatty acid metabolism<ref name='LIB:Riley_2006'/>, B1187<ref name='LIB:EcoCyc10.6'/>, Ole<ref name='LIB:EcoCyc10.6'/>, Dec<ref name='LIB:EcoCyc10.6'/>, ThdB<ref name='LIB:EcoCyc10.6'/>, OleR<ref name='LIB:EcoCyc10.6'/>, FadR<ref name='LIB:EcoCyc10.6'/>, negative regulator for fad regulon, and positive activator of fabA<ref name='LIB:EcoCyc10.6'/>
''ECK1175, b1187, JW1176, dec, ole, thdB, oleR''<ref name='LIB:Riley_2006'/>, oleR''
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!{{table_heading_style}} |Description
!align=left {{table_heading_style}} |Product Desc.
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FadR transcriptional dual regulator<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>
FadR transcriptional dual regulator<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>


 
Repressor/activator for fatty acid metabolism regulon; fatty acid-responsive transcription factor; fabAB, iclR activator (regulates aceBAK, glyoxylate shunt); fad repressor; homodimeric<ref name='LIB:EcoGene'/>
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!align=left {{table_heading_style}} |Product Synonyms(s)
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''DNA-binding transcriptional dual regulator of fatty acid metabolism<ref name='LIB:Riley_2006'/>, B1187<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, Ole<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, Dec<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, ThdB<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, OleR<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, FadR<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, negative regulator for fad regulon, and positive activator of fabA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/> , dec, ECK1175, JW1176, ole, oleR, thdB, b1187''
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!align=left {{table_heading_style}} |Function from GO
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<GO_nr />
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!{{table_heading_style}} |Knock-Out Phenotype
!align=left {{table_heading_style}} |Knock-Out Phenotype
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!{{table_heading_style}} |Regulation/Expression
!align=left {{table_heading_style}} |Regulation/Expression
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transcription unit(s): [[:Category:txn_units:fadR|fadR]]<ref name='LIB:EcoCyc10.6'/>  
transcription unit(s): [[:Category:Txn_unit:fadR|fadR]]<ref name='LIB:EcoCyc10.6'/>  
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!{{table_heading_style}} |Regulation/Activity
!align=left {{table_heading_style}} |Regulation/Activity
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[[File:porteco.png|link=http://porteco.org/AjaxSearch.jsp?searchString=fadR&s=search]] [[File:EcoCyc.gif|link=http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=EG10281]] [[File:regulondb.jpg|link=http://regulondb.ccg.unam.mx/gene?term=ECK120000275&organism=ECK12&format=jsp&type=gene ]] <br/><br/> [[File:dnadisplay.png|link=http://ecoliwiki.net/tools/display_dna.php?gene=fadR&loc=MG1655%3A1234161..1234880,W3110%3A1236515..1237234,DH10B%3A1274402..1275121,REL606%3A1235088..1235807,BW2952%3A1122882..1123601]] [[File:proteindisplay.png|link=http://ecoliwiki.net/tools/display_protein.php?f=NC_000913&start=1122882&end=1123601&gene=fadR&aa=mvikaqspagfaeeyiiesiwnnrfppgtilpaerelseligvtrttlrevlqrlardgwltiqhgkptkvnnfwetsglniletlarldhesvpqlidnllsvrtnistifirtafrqhpdkaqevlatanevadhadafaeldynifrglafasgnpiyglilngmkglytrigrhyfanpearslalgfyhklsalcsegahdqvyetvrryghesgeiwhrmqknlpgdlaiqgr]]&nbsp;&nbsp;  [[File:pubmed.jpg|link=http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Search&Term=fadR+AND+escherichia+coli]]&nbsp;&nbsp;  [[File:textpresso.jpg|link=http://textpresso.tamu.edu/cgi-bin/textpresso/search?q=fadR]]&nbsp;&nbsp;
 
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==Notes==
===Notes===
{{BacktoTop}}
 
The fad genes are induced and fabAB, iclR are repressed by long chain acyl-CoA thioesters binding to and releasing FadR from the DNA. FadR is a GntR-type DNA-binding transcriptional regulator.<ref name='LIB:EcoGene'/>
 




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==References==
==References==
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Latest revision as of 21:51, 27 May 2013

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
References Suggestions
Standard Name

fadR

Gene Synonym(s)

ECK1175, b1187, JW1176, dec, ole, thdB, oleR[1], oleR

Product Desc.

FadR transcriptional dual regulator[2][3]

Repressor/activator for fatty acid metabolism regulon; fatty acid-responsive transcription factor; fabAB, iclR activator (regulates aceBAK, glyoxylate shunt); fad repressor; homodimeric[4]

Product Synonyms(s)

DNA-binding transcriptional dual regulator of fatty acid metabolism[1], B1187[2][1], Ole[2][1], Dec[2][1], ThdB[2][1], OleR[2][1], FadR[2][1], negative regulator for fad regulon, and positive activator of fabA[2][1] , dec, ECK1175, JW1176, ole, oleR, thdB, b1187

Function from GO

<GO_nr />

Knock-Out Phenotype
Regulation/Expression

transcription unit(s): fadR[2]

Regulation/Activity
Quick Links



        

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Notes

[back to top]


The fad genes are induced and fabAB, iclR are repressed by long chain acyl-CoA thioesters binding to and releasing FadR from the DNA. FadR is a GntR-type DNA-binding transcriptional regulator.[4]



References

[back to top]


  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
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