cls:Gene Product(s): Difference between revisions

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|{{Sub}}[[#Localization |Localization]]
|{{Sub}}[[#Localization |Localization]]
|{{Sub}}[[#Sequence|Sequence]]
|{{Sub}}[[#Sequence|Sequence]]
|{{Sub}}[[#Domains/Motifs/Modification Sites|Domains]]
|{{Sub}}[[#Structure|Structure]]
|{{Sub}}[[#Structure|Structure]]
|{{Sub}}[[#Gene Product Resources|Resources]]
|{{Sub}}[[#Gene Product Resources|Resources]]
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|-
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!{{table heading style}} |Standard name
!align=left {{table heading style}} |Standard name
|
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Cls product
Cls  
|-
|-
!{{table heading style}} |Synonyms
!align=left {{table heading style}} |Synonyms
|
||
cardiolipin synthase 1 product<ref name='LIB:Riley_2006'/>, B1249 product<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, YciJ product<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, Nov product<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, Cls product<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>  
''cardiolipin synthase 1<ref name='LIB:Riley_2006'/>, B1249<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, YciJ<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, Nov<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, Cls<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/> , ECK1243, JW1241, nov, yciJ, b1249''
|-
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!{{table heading style}} |Product description
!align=left {{table heading style}} |Product description
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CARDIOLIPSYN-MONOMER<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>


Cardiolipin synthase; mutants dihydroxybutylphosphonate resistant; novobiocin sensitivity<ref name='LIB:EcoGene'/>
|-
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!{{table heading style}} |EC number (for enzymes)
!align=left {{table heading style}} |EC number (for enzymes)
|
||
** [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.8.- 2.7.8.-]<ref name='LIB:Riley_2006'/>
[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.8.- 2.7.8.-]<ref name='LIB:Riley_2006'/>
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<protect><!--Nomenclature_notes--></protect>
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===Notes===
===Notes===
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{{BacktoTop}}
{{BacktoTop}}
<protect>
<protect>
<big>'''Gene Ontology'''</big>
<big>'''Gene Ontology'''</big><br /><!--box uid=421aa90e079fa326b6494f812ad13e79.22455.T46aa5f775286b-->
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{| border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;"  id="T46aa5f775286b"  class=" tableEdit GO_table_product dataTable"   
|- {{table_heading_style}}
|- {{table_heading_style}}
!|Qualifier!!GO ID!!GO term name!!Reference(s)!!Evidence Code!!with/from!!Aspect!!Notes!!Status
!|Qualifier!!GO ID!!GO term name!!Reference!!Evidence Code!!with/from!!Aspect!!Notes!!Status
|-
|
 
|
GO:0005886
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plasma membrane
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GOA:hamap<br />GO_REF:0000020
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IEA: Inferred from Electronic Annotation
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HAMAP:MF_00190
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C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|
 
|
GO:0005886
|
plasma membrane
|
GOA:spkw<br />SP_KW:GO_REF:0000004
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IEA: Inferred from Electronic Annotation
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SP_KW:KW-0997
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C
|
Seeded from [[EcoCyc]] (v14.0)
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complete
|-  
|-  
|
|


|
|
[[Category:GO:0003824_!_catalytic_activity]][http://gowiki.tamu.edu/wiki/index.php/Category:GO:0003824_!_catalytic_activity GO:0003824]
GO:0005886
|
|
catalytic_activity
plasma membrane
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|
[http://www.geneontology.org/cgi-bin/references.cgi/#GO_REF:0000002 GO_REF:0000002]<br />
GOA:spkw<br />SP_KW:GO_REF:0000004
|
|
IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
|
|
InterPro:IPR001736
SP_KW:KW-1003
|
|
F
C
|
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete
|-  
|-  
|
|


|
|
[[Category:GO:0008152_!_metabolic_process]][http://gowiki.tamu.edu/wiki/index.php/Category:GO:0008152_!_metabolic_process GO:0008152]
GO:0008152
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|
metabolism
metabolic process
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[http://www.geneontology.org/cgi-bin/references.cgi/#GO_REF:0000002 GO_REF:0000002]<br />
GOA:interpro<br />GO_REF:0000002
|
|
IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
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P
P
|
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete
|-  
|-  
|
|


|
|
[[Category:GO:0008654_!_phospholipid_biosynthetic_process]][http://gowiki.tamu.edu/wiki/index.php/Category:GO:0008654_!_phospholipid_biosynthetic_process GO:0008654]
GO:0008654
|
|
phospholipid_biosynthesis
phospholipid biosynthetic process
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|
[http://www.geneontology.org/cgi-bin/references.cgi/#GO_REF:0000004 GO_REF:0000004]<br />
GOA:hamap<br />GO_REF:0000020
|
|
IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
|
|
SP_KW:KW-0594
HAMAP:MF_00190
|
|
P
P
|
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete
|-  
|-  
|
|
 
|
|
[[Category:GO:0016021_!_integral_to_membrane]][http://gowiki.tamu.edu/wiki/index.php/Category:GO:0016021_!_integral_to_membrane GO:0016021]
GO:0008654
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|
integral to membrane
phospholipid biosynthetic process
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|
GOA:spkw<br />SP_KW:GO_REF:0000004
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|
IEA: Inferred from Electronic Annotation
|
|
SP_KW:KW-0594
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|
C
P
|
|
Seeded from Riley et  al 2006 <ref name='LIB:Riley_2006'/>.  
Seeded from [[EcoCyc]] (v14.0)
|
|
required fields missing 
complete
|-  
|-  
|
|


|
|
[[Category:GO:0008654_!_phospholipid_biosynthetic_process]][http://gowiki.tamu.edu/wiki/index.php/Category:GO:0008654_!_phospholipid_biosynthetic_process GO:0008654]
GO:0016020
|
|
phospholipid_biosynthesis
membrane
|
|
[http://www.geneontology.org/cgi-bin/references.cgi/#GO_REF:0000020 GO_REF:0000020]<br />
GOA:spkw<br />SP_KW:GO_REF:0000004
|
|
IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
|
|
HAMAP:MF_00190
SP_KW:KW-0472
|
|
P
C
|
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete
|-  
|-  
|
|
 
|
|
[[Category:GO:0042493_!_response_to_drug]][http://gowiki.tamu.edu/wiki/index.php/Category:GO:0042493_!_response_to_drug GO:0042493]
GO:0016021
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|
response to drug
integral to membrane
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|
GOA:spkw<br />SP_KW:GO_REF:0000004
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|
IEA: Inferred from Electronic Annotation
|
|
SP_KW:KW-0812
|
|
P
C
|
|
Seeded from EcoCyc 11.1<ref name='LIB:EcoCyc11.1'/>.  
Seeded from [[EcoCyc]] (v14.0)
|
|
required fields missing 
complete
|-  
|-  
|
|


|
|
[[Category:GO:0016020_!_membrane]][http://gowiki.tamu.edu/wiki/index.php/Category:GO:0016020_!_membrane GO:0016020]
GO:0016021
|
|
membrane
integral to membrane
|
|
[http://www.geneontology.org/cgi-bin/references.cgi/#GO_REF:0000004 GO_REF:0000004]<br />
GO_REF:0000023
|
|
IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
|
|
SP_KW:KW-0397
SP_SL:SL-9909
|
|
C
C
|
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|
 
|
|
GO:0008808
|
cardiolipin synthase activity
|
PMID:353047
|
IMP: Inferred from Mutant Phenotype
|
 
|
F
|
 
|
complete


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<span id="Interactions"></span><big>'''Interactions'''</big>
<span id="Interactions"></span><big>'''Interactions'''</big>
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!Partner Type!!Partner!!Notes
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<!--Function_notes--></protect>
<!--Function_notes--></protect>
===Notes===
===Notes===
 
Required for synthesis of [[cardiolipin]].


==Localization==
==Localization==
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!Compartment!!Description!!Evidence!!Notes
!|Compartment!!Description!!Evidence!!Reference/Source!!Notes
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plasma membrane
plasma membrane
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From EcoCyc<ref name='LIB:EcoCyc11.1'/>   
From EcoCyc<ref name='LIB:EcoCyc11.1'/>  
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!align=left {{table heading style}} |Name
||
 
|-
|-
!{{table heading style}} |Sequence
!align=left {{table heading style}} |Sequence
|
||
[http://biocyc.org/ECOLI/sequence-aa?object=CARDIOLIPSYN-MONOMER at EcoCyc]  
[http://biocyc.org/ECOLI/sequence-aa?object=CARDIOLIPSYN-MONOMER at EcoCyc]  
<pre>MTTVYTLVSW LAILGYWLLI AGVTLRILMK RRAVPSAMAW LLIIYILPLV GIIAYLAVGE
<pre>MTTVYTLVSW LAILGYWLLI AGVTLRILMK RRAVPSAMAW LLIIYILPLV GIIAYLAVGE
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FFSPLL</pre>  
FFSPLL</pre>  
|-
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!{{table heading style}} |Mol. Wt
!align=left {{table heading style}} |Length
|
||
54.82 kDa (calc) <ref name='LIB:EcoCyc10.6'/>
486
|-
|-
!{{table heading style}} |pI
!align=left {{table heading style}} |Mol. Wt
|
||
54.824 kDa
|-
|-
!{{table heading style}} |Extinction coefficient
!align=left {{table heading style}} |pI
|
||
93850 - 94475 (calc based on 15 Y, 13 W, and 5 C residues)  
8.4 (calculated)
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!align=left {{table heading style}} |Extinction coefficient
||
93,850 - 94,475 (calc based on 15 Y, 13 W, and 5 C residues)
 
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<big>'''Domains/Motifs/Modification Sites'''</big>
 
<span id="Domains/Motifs/Modification Sites"><big>'''Domains/Motifs/Modification Sites'''</big></span>
<table>
<tr align="left" valign="top">
<td>
 
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!Type!!Residues!!Description!!Notes
!|Type!!Residues!!Description!!Notes!!References
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|
Domain
|
219..246
|
[http://pfam.janelia.org/family/PF00614 PF00614  Phospholipase D Active site motif]
|
 
|
PMID:19920124
|-
|
Domain
|
399..426
|
[http://pfam.janelia.org/family/PF00614 PF00614  Phospholipase D Active site motif]
|
 
|
PMID:19920124
 
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<span id="Structure"></span><big>'''Structure'''</big>
</td>
<td>
<!-- motifs column 2-->
<motif_map/>
{{TMHMM Picture|cls}}
</td>
</tr>
</table>
 
<table><tr valign='top'><td>
<span id='Structure'></span><big>'''Structure'''</big><br />
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|- {{table heading style}}
 
!Structure Type!!Organism!!Accession!!Residues covered!!Notes
|-
|-class='sortbottom'
!align=left {{table heading style}} |Structures
|[{{SERVER}}{{SCRIPTPATH}}/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.22455.A46a7f26810b00&page=22455&pagename={{FULLPAGENAMEE}} edit table] || || || ||
||
<beststructure>
gene=cls
taxon=562,83333
</beststructure>
|-
!align=left {{table heading style}} |Models
||
View models at:
* [http://www.proteinmodelportal.org/query/uniprot/P0A6H8 Protein Model Portal]
* [http://bioinf.cs.ucl.ac.uk/genome3d/read?uniprot_id=P0A6H8 PSI-PRED (P0A6H8)]
* [http://spock.genes.nig.ac.jp/~genome/cgi-bin/gkeytext.pl.cgi?A&QUERY1=P0A6H8 Genomes TO Protein (P0A6H8)] (GTOP)
 
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<!--Structure_notes--></protect>
</td><td></protect>
==== Structure figures ====
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
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</td><tr><table><!--Structure_notes--></protect>
===Notes===
===Notes===


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===Notes===
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!Database!!Accession!!Notes
!|Database!!Accession!!Notes
|-
|-
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[http://www.ncbi.nlm.nih.gov/protein NCBI (Protein)] ([[NCBI (Protein)|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/protein/16129210 GI:16129210]
|
Escherichia coli str. K-12 substr. MG1655
|-  
|
|
[http://ecocyc.org EcoCyc] ([[EcoCyc|EcoliWiki Page]])  
[http://www.ncbi.nlm.nih.gov/protein NCBI (Protein)] ([[NCBI (Protein)|EcoliWiki Page]])
|
|
[http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=CARDIOLIPSYN-MONOMER EcoCyc:CARDIOLIPSYN-MONOMER]
[http://www.ncbi.nlm.nih.gov/protein/NP_415765.1 GeneID:945821]
|
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Escherichia coli str. K-12 substr. MG1655
|-
|-  
|
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[http://uniprot.org/ UniProt] ([[UniProt|EcoliWiki Page]])  
[http://www.pir.uniprot.org/ UniProt] ([[UniProt|EcoliWiki Page]])
|
|
[[uniprot:P0A6H8|UniProt:P0A6H8]] 
[http://www.uniprot.org/uniprot/P0A6H8 UniProtKB/Swiss-Prot:P0A6H8]
|
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Escherichia coli str. K-12 substr. MG1655
|-
|-  
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[http://pfam.sanger.ac.uk/ PFAM] ([[PFAM|EcoliWiki Page]])  
[http://www.ncbi.nlm.nih.gov/gene NCBI (Gene)] ([[NCBI (Gene)|EcoliWiki Page]])
|
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[http://pfam.sanger.ac.uk/family?acc=PF00614 PFAM:PF00614]
[http://www.ncbi.nlm.nih.gov/gene?term=945821 GeneID:945821]
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Escherichia coli str. K-12 substr. MG1655
|-
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[http://www.ncbi.nlm.nih.gov/RefSeq/ RefSeq] ([[RefSeq|EcoliWiki Page]])
[[RegulonDB]]
|
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[http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=NP_415765 RefSeq:NP_415765] 
RegulonDB:
|
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''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]]
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[http://modbase.compbio.ucsf.edu ModBase] ([[ModBase|EcoliWiki Page]])
[[EchoBASE]]
|
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[http://salilab.org/modbase/searchbyid?databaseID=P0A6H8 ModBase:P0A6H8] 
EchoBASE:
|
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''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]]
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<references/>
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__NOTOC__
__NOTOC__
</noinclude>
===Categories===
===Categories===
{{BacktoTop}}
{{BacktoTop}}
[[Category:Proteins]]
[[Category:Proteins]]
[[Category:GO:0016021_!_integral to membrane]][[Category:GO:0008654_!_phospholipid biosynthetic process]][[Category:GO:0042493_!_response to drug]][[Category:Location:plasma membrane]]

Latest revision as of 20:36, 17 February 2015

{{#css:Suppresslinks.css}}<css>h1 .editsection { display:none;} h2 .editsection { display:none;}</css>

Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

Cls

Synonyms

cardiolipin synthase 1[1], B1249[2][1], YciJ[2][1], Nov[2][1], Cls[2][1] , ECK1243, JW1241, nov, yciJ, b1249

Product description

Cardiolipin synthase; mutants dihydroxybutylphosphonate resistant; novobiocin sensitivity[3]

EC number (for enzymes) 
2.7.8.-[1]
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Notes

Function

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Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0005886

plasma membrane

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00190

C

Seeded from EcoCyc (v14.0)

complete

GO:0005886

plasma membrane

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0997

C

Seeded from EcoCyc (v14.0)

complete

GO:0005886

plasma membrane

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-1003

C

Seeded from EcoCyc (v14.0)

complete

GO:0008152

metabolic process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001736

P

Seeded from EcoCyc (v14.0)

complete

GO:0008654

phospholipid biosynthetic process

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00190

P

Seeded from EcoCyc (v14.0)

complete

GO:0008654

phospholipid biosynthetic process

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0594

P

Seeded from EcoCyc (v14.0)

complete

GO:0016020

membrane

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0472

C

Seeded from EcoCyc (v14.0)

complete

GO:0016021

integral to membrane

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0812

C

Seeded from EcoCyc (v14.0)

complete

GO:0016021

integral to membrane

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-9909

C

Seeded from EcoCyc (v14.0)

complete

GO:0008808

cardiolipin synthase activity

PMID:353047[4]

IMP: Inferred from Mutant Phenotype

F

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence
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Notes

Required for synthesis of cardiolipin.

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes

plasma membrane

From EcoCyc[5]


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Notes

Structure and Physical Properties

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Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MTTVYTLVSW LAILGYWLLI AGVTLRILMK RRAVPSAMAW LLIIYILPLV GIIAYLAVGE
LHLGKRRAER ARAMWPSTAK WLNDLKACKH IFAEENSSVA APLFKLCERR QGIAGVKGNQ
LQLMTESDDV MQALIRDIQL ARHNIEMVFY IWQPGGMADQ VAESLMAAAR RGIHCRLMLD
SAGSVAFFRS PWPELMRNAG IEVVEALKVN LMRVFLRRMD LRQHRKMIMI DNYIAYTGSM
NMVDPRYFKQ DAGVGQWIDL MARMEGPIAT AMGIIYSCDW EIETGKRILP PPPDVNIMPF
EQASGHTIHT IASGPGFPED LIHQALLTAA YSAREYLIMT TPYFVPSDDL LHAICTAAQR
GVDVSIILPR KNDSMLVGWA SRAFFTELLA AGVKIYQFEG GLLHTKSVLV DGELSLVGTV
NLDMRSLWLN FEITLAIDDK GFGADLAAVQ DDYISRSRLL DARLWLKRPL WQRVAERLFY
FFSPLL
Length

486

Mol. Wt

54.824 kDa

pI

8.4 (calculated)

Extinction coefficient

93,850 - 94,475 (calc based on 15 Y, 13 W, and 5 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Domain

219..246

PF00614 Phospholipase D Active site motif

PMID:19920124[6]

Domain

399..426

PF00614 Phospholipase D Active site motif

PMID:19920124[6]

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<motif_map/>

tmhmm.php?gene=cls&show=pic&.jpg
Click the image to view raw output from TMHMM.

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=cls taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16129210

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:945821

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P0A6H8

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:945821

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  4. ↑ Pluschke, G et al. (1978) Function of phospholipids in Escherichia coli. Characterization of a mutant deficient in cardiolipin synthesis. J. Biol. Chem. 253 5048-55 PubMed
  5. ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  6. ↑ 6.0 6.1 Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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