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{{Tab On|Quickview|tolA}}{{Tab|Gene|tolA}}{{Tab|Gene Product(s)|tolA}}{{Tab|Expression|tolA}}{{Tab|Evolution|tolA}}{{Tab|On One Page|tolA}}{{TabsBottom}}
{{Tab On|Quickview|tolA}}{{Tab|Gene|tolA}}{{Tab|Gene Product(s)|tolA}}{{Tab|Expression|tolA}}{{Tab|Evolution|tolA}}{{Tab|On One Page|tolA}}{{TabsBottom}}
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!{{table_heading_style}} |Gene Name
!align=left {{table_heading_style}} |Standard Name
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[[tolA:Gene|''tolA]]'' (synonyms: ''ECK0728, b0739, JW0729, cim, excC, lky, tol-2'')<ref name='LIB:Riley_2006'/>
''tolA''
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!{{table_heading_style}} |Product(s)  
!align=left {{table_heading_style}} |Gene Synonym(s)
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[[tolA:Gene_Product(s)|TolA product]]<ref name='LIB:Riley_2006'/>: membrane anchored protein in TolA-TolQ-TolR complex<ref name='LIB:Riley_2006'/>, B0739<ref name='LIB:EcoCyc10.6'/>, Lky<ref name='LIB:EcoCyc10.6'/>, Cim<ref name='LIB:EcoCyc10.6'/>, ExcC<ref name='LIB:EcoCyc10.6'/>, TolA<ref name='LIB:EcoCyc10.6'/>, [[:Category:Complex:Tol-Pal Cell Envelope Complex|Tol-Pal Cell Envelope Complex]]<ref name='LIB:EcoCyc10.6'/>, [[:Category:Complex:The Tol-Pal Cell Envelope Complex|The Tol-Pal Cell Envelope Complex]]<ref name='LIB:EcoCyc11.1'/>, [[:Category:Complex:The Colicin A Import System|The Colicin A Import System]]<ref name='LIB:EcoCyc11.1'/>, [[:Category:Complex:Colicin S4 Transport System|Colicin S4 Transport System]]<ref name='LIB:EcoCyc11.1'/>
''ECK0728, b0739, JW0729, cim, excC, lky, tol-2''<ref name='LIB:Riley_2006'/>
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!{{table_heading_style}} |Description
!align=left {{table_heading_style}} |Product Desc.
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TolA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>
TolA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>;


Component of [[:Category:Complex:Tol-Pal Cell Envelope Complex|Tol-Pal Cell Envelope Complex]]<ref name='LIB:EcoCyc10.6'/>; [[:Category:Complex:The Tol-Pal Cell Envelope Complex|The Tol-Pal Cell Envelope Complex]]<ref name='LIB:EcoCyc11.1'/>; [[:Category:Complex:The Colicin A Import System|The Colicin A Import System]]<ref name='LIB:EcoCyc11.1'/>; [[:Category:Complex:Colicin S4 Transport System|Colicin S4 Transport System]]<ref name='LIB:EcoCyc11.1'/>


Tolerance to group A colicins, single-stranded filamentous DNA phage; required for OM integrity; membrane protein; bacteriocin tolerant<ref name='LIB:EcoGene'/>
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!align=left {{table_heading_style}} |Product Synonyms(s)
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''membrane anchored protein in TolA-TolQ-TolR complex<ref name='LIB:Riley_2006'/>, B0739<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, Lky<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, Cim<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, ExcC<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, TolA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/> , cim, ECK0728, excC, JW0729, lky, b0739''
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!align=left {{table_heading_style}} |Function from GO
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<GO_nr />
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!{{table_heading_style}} |Knock-Out Phenotype
!align=left {{table_heading_style}} |Knock-Out Phenotype
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!{{table_heading_style}} |Regulation/Expression
!align=left {{table_heading_style}} |Regulation/Expression
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transcription unit(s): [[:Category:txn_units:ybgC-tolQRA|ybgC-tolQRA]]<ref name='LIB:EcoCyc10.6'/>  
transcription unit(s): [[:Category:Txn_unit:ybgC-tolQRA|ybgC-tolQRA]]<ref name='LIB:EcoCyc10.6'/>  
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!{{table_heading_style}} |Regulation/Activity
!align=left {{table_heading_style}} |Regulation/Activity
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!align=left {{table_heading_style}} |Quick Links
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[[File:porteco.png|link=http://porteco.org/AjaxSearch.jsp?searchString=tolA&s=search]] [[File:EcoCyc.gif|link=http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=EG11007]] [[File:regulondb.jpg|link=http://regulondb.ccg.unam.mx/gene?term=ECK120000996&organism=ECK12&format=jsp&type=gene ]] <br/><br/> [[File:dnadisplay.png|link=http://ecoliwiki.net/tools/display_dna.php?gene=tolA&loc=MG1655%3A775565..776830,W3110%3A776764..778029,DH10B%3A828157..829422,REL606%3A757224..758489,BW2952%3A678325..679590]] [[File:proteindisplay.png|link=http://ecoliwiki.net/tools/display_protein.php?f=NC_000913&start=678325&end=679590&gene=tolA&aa=mskateqndklkraiiisavlhvilfaaliwssfdenieasagggggssidavmvdsgavveqykrmqsqessakrsdeqrkmkeqqaaeelrekqaaeqerlkqlekerlaaqeqkkqaeeaakqaelkqkqaeeaaakaaadakakaeadakaaeeaakkaaadakkkaeaeaakaaaeaqkkaeaaaaalkkkaeaaeaaaaearkkaateaaekakaeaekkaaaekaaadkkaaaekaaadkkaaekaaaekaaadkkaaaekaaadkkaaaakaaaekaaaakaaaeaddifgelssgknapktgggakgnnaspagsgntknngasgadinnyagqiksaieskfydassyagktctlriklapdgmlldikpeggdpalcqaalaaaklakipkppsqavyevfknapldfkp]]&nbsp;&nbsp;  [[File:pubmed.jpg|link=http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Search&Term=tolA+AND+escherichia+coli]]&nbsp;&nbsp;  [[File:textpresso.jpg|link=http://textpresso.tamu.edu/cgi-bin/textpresso/search?q=tolA]]&nbsp;&nbsp;
 
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==Notes==
===Notes===
{{BacktoTop}}


Cell envelope integrity is stabilized by the Tol-Pal system linking inner and outer membranes. Mutants have elevated OM vesiculation (McBroom, 2006).<ref name='LIB:EcoGene'/>
Phages can bind to the periplasmic domain of tolA and thus infect the cell (see [[Phage_f1]]). <ref name='LIB:Bacteriophages'/>


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==References==
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Latest revision as of 21:45, 27 May 2013

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
References Suggestions
Standard Name

tolA

Gene Synonym(s)

ECK0728, b0739, JW0729, cim, excC, lky, tol-2[1]

Product Desc.

TolA[2][3];

Component of Tol-Pal Cell Envelope Complex[2]; The Tol-Pal Cell Envelope Complex[3]; The Colicin A Import System[3]; Colicin S4 Transport System[3]

Tolerance to group A colicins, single-stranded filamentous DNA phage; required for OM integrity; membrane protein; bacteriocin tolerant[4]

Product Synonyms(s)

membrane anchored protein in TolA-TolQ-TolR complex[1], B0739[2][1], Lky[2][1], Cim[2][1], ExcC[2][1], TolA[2][1] , cim, ECK0728, excC, JW0729, lky, b0739

Function from GO

<GO_nr />

Knock-Out Phenotype
Regulation/Expression

transcription unit(s): ybgC-tolQRA[2]

Regulation/Activity
Quick Links



        

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Notes

[back to top]


Cell envelope integrity is stabilized by the Tol-Pal system linking inner and outer membranes. Mutants have elevated OM vesiculation (McBroom, 2006).[4]

Phages can bind to the periplasmic domain of tolA and thus infect the cell (see Phage_f1). [5]


References

[back to top]


  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 3.2 3.3 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ Edited by Richard Calendar (2006) The Bacteriophages (Oxford University Press, Oxford, NY) ISBN 0-19-514850-9
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