groL:Quickview: Difference between revisions

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!{{table_heading_style}} |Gene Name
!align=left {{table_heading_style}} |Standard Name
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[[groL:Gene|''groL]]'' (synonyms: ''ECK4137, b4143, JW4103, groEL, mopB, groE, hdh, mopA, tabB'')<ref name='LIB:Riley_2006'/><ref name='LIB:EcoCyc10.6'/>
''groL''
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!{{table_heading_style}} |Product(s)  
!align=left {{table_heading_style}} |Gene Synonym(s)
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[[groL:Gene_Product(s)|GroL product]]<ref name='LIB:Riley_2006'/>: Cpn60 chaperonin GroEL, large subunit of GroESL product, B4143 product, Hdh product, TabB product, MopA product, GroEL product
''ECK4137, b4143, JW4103, groEL, mopB, groE, hdh, mopA, tabB''<ref name='LIB:Riley_2006'/><ref name='LIB:EcoCyc10.6'/>
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!{{table_heading_style}} |Description
!align=left {{table_heading_style}} |Product Desc.
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GroEL, chaperone Hsp60, peptide-dependent ATPase, heat shock protein<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>  
GroEL, chaperone Hsp60, peptide-dependent ATPase, heat shock protein<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>;


Component of [[:Category:Complex:GroEL-GroES Chaperonin-CPLX|GroEL-GroES Chaperonin-CPLX]]<ref name='LIB:EcoCyc11.1'/>
Component of [[:Category:Complex:GroEL-GroES Chaperonin-CPLX|GroEL-GroES Chaperonin-CPLX]]<ref name='LIB:EcoCyc11.1'/>


Chaperonin Cpn60; phage morphogenesis; GroESL large subunit GroEL, weak ATPase; binds Ap4A<ref name='LIB:EcoGene'/>
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!align=left {{table_heading_style}} |Product Synonyms(s)
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''Cpn60 chaperonin GroEL, large subunit of GroESL<ref name='LIB:Riley_2006'/>, B4143<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, Hdh<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, TabB<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, GroL<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, MopA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, GroEL<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/> , ECK4137, groEL, JW4103, mopA, b4143''
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!align=left {{table_heading_style}} |Function from GO
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<GO_nr />
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!{{table_heading_style}} |Knock-Out Phenotype
!align=left {{table_heading_style}} |Knock-Out Phenotype
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!{{table_heading_style}} |Regulation/Expression
!align=left {{table_heading_style}} |Regulation/Expression
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transcription unit(s): [[:Category:Txn_unit:groS|groS]]<ref name='LIB:EcoCyc10.6'/>, groS, groES  
transcription unit(s): [[:Category:Txn_unit:groS|groS]]<ref name='LIB:EcoCyc10.6'/>, groS, groES  
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!{{table_heading_style}} |Regulation/Activity
!align=left {{table_heading_style}} |Regulation/Activity
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!align=left {{table_heading_style}} |Quick Links
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[[File:porteco.png|link=http://porteco.org/AjaxSearch.jsp?searchString=groL&s=search]] [[File:EcoCyc.gif|link=http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=EG10599]] [[File:regulondb.jpg|link=http://regulondb.ccg.unam.mx/gene?term=ECK120000592&organism=ECK12&format=jsp&type=gene ]] <br/><br/> [[File:dnadisplay.png|link=http://ecoliwiki.net/tools/display_dna.php?gene=groL&loc=MG1655%3A4369048..4370694,W3110%3A4375705..4377351,DH10B%3A4469410..4471056,REL606%3A4349746..4351392,BW2952%3A4307783..4309429]] [[File:proteindisplay.png|link=http://ecoliwiki.net/tools/display_protein.php?f=NC_000913&start=4307783&end=4309429&gene=groL&aa=maakdvkfgndarvkmlrgvnvladavkvtlgpkgrnvvldksfgaptitkdgvsvareieledkfenmgaqmvkevaskandaagdgtttatvlaqaiiteglkavaagmnpmdlkrgidkavtaaveelkalsvpcsdskaiaqvgtisansdetvgkliaeamdkvgkegvitvedgtglqdeldvvegmqfdrgylspyfinkpetgavelespfilladkkisniremlpvleavakagkplliiaedvegealatlvvntmrgivkvaavkapgfgdrrkamlqdiatltggtviseeigmelekatledlgqakrvvinkdtttiidgvgeeaaiqgrvaqirqqieeatsdydreklqervaklaggvavikvgaatevemkekkarvedalhatraaveegvvagggvalirvaskladlrgqnedqnvgikvalrameaplrqivlncgeepsvvantvkggdgnygynaateeygnmidmgildptkvtrsalqyaasvaglmittecmvtdlpkndaadlgaaggmggmggmggmm]]&nbsp;&nbsp;  [[File:pubmed.jpg|link=http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Search&Term=groL+AND+escherichia+coli]]&nbsp;&nbsp;  [[File:textpresso.jpg|link=http://textpresso.tamu.edu/cgi-bin/textpresso/search?q=groL]]&nbsp;&nbsp;
 
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===Notes===
===Notes===
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groL is an essential gene. GroEL binds and regulates rpoH.  Cells deficient in GroEL and GroES lyse due to inability to produce cell wall as a result of the reduced level of DapA, the first enzyme in the DAP synthesis pathway. Growth below 8C is impaired due to GroESL inactivation and can be rescued by transgenic Oleispira antarctica Cpn10/60.  Overproduction of GroESL can supress tig/dnaK synthetic lethality at 30 degrees C.<ref name='LIB:EcoGene'/>




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==References==
==References==
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Latest revision as of 21:49, 27 May 2013

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
References Suggestions
Standard Name

groL

Gene Synonym(s)

ECK4137, b4143, JW4103, groEL, mopB, groE, hdh, mopA, tabB[1][2]

Product Desc.

GroEL, chaperone Hsp60, peptide-dependent ATPase, heat shock protein[2][3];

Component of GroEL-GroES Chaperonin-CPLX[3]

Chaperonin Cpn60; phage morphogenesis; GroESL large subunit GroEL, weak ATPase; binds Ap4A[4]

Product Synonyms(s)

Cpn60 chaperonin GroEL, large subunit of GroESL[1], B4143[2][1], Hdh[2][1], TabB[2][1], GroL[2][1], MopA[2][1], GroEL[2][1] , ECK4137, groEL, JW4103, mopA, b4143

Function from GO

<GO_nr />

Knock-Out Phenotype
Regulation/Expression

transcription unit(s): groS[2], groS, groES

Regulation/Activity
Quick Links



        

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Notes

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groL is an essential gene. GroEL binds and regulates rpoH. Cells deficient in GroEL and GroES lyse due to inability to produce cell wall as a result of the reduced level of DapA, the first enzyme in the DAP synthesis pathway. Growth below 8C is impaired due to GroESL inactivation and can be rescued by transgenic Oleispira antarctica Cpn10/60. Overproduction of GroESL can supress tig/dnaK synthetic lethality at 30 degrees C.[4]



References

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  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
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