cls:Gene Product(s): Difference between revisions
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|{{Sub}}[[#Localization |Localization]] | |{{Sub}}[[#Localization |Localization]] | ||
|{{Sub}}[[#Sequence|Sequence]] | |{{Sub}}[[#Sequence|Sequence]] | ||
|{{Sub}}[[#Domains/Motifs/Modification Sites|Domains]] | |||
|{{Sub}}[[#Structure|Structure]] | |{{Sub}}[[#Structure|Structure]] | ||
|{{Sub}}[[#Gene Product Resources|Resources]] | |{{Sub}}[[#Gene Product Resources|Resources]] | ||
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!align=left {{table heading style}} |Synonyms | !align=left {{table heading style}} |Synonyms | ||
|| | || | ||
cardiolipin synthase 1<ref name='LIB:Riley_2006'/>, B1249<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, YciJ<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, Nov | ''cardiolipin synthase 1<ref name='LIB:Riley_2006'/>, B1249<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, YciJ<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, Nov<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, Cls<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/> , ECK1243, JW1241, nov, yciJ, b1249'' | ||
|- | |- | ||
!align=left {{table heading style}} |Product description | !align=left {{table heading style}} |Product description | ||
|| | || | ||
Cardiolipin synthase; mutants dihydroxybutylphosphonate resistant; novobiocin sensitivity<ref name='LIB:EcoGene'/> | |||
|- | |- | ||
!align=left {{table heading style}} |EC number (for enzymes) | !align=left {{table heading style}} |EC number (for enzymes) | ||
|| | || | ||
[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.8.- 2.7.8.-]<ref name='LIB:Riley_2006'/> | |||
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<protect><!--Nomenclature_notes--></protect> | <protect><!--Nomenclature_notes--></protect> | ||
===Notes=== | ===Notes=== | ||
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{{BacktoTop}} | {{BacktoTop}} | ||
<protect> | <protect> | ||
<big>'''Gene Ontology'''</big><br /> | <big>'''Gene Ontology'''</big><br /><!--box uid=421aa90e079fa326b6494f812ad13e79.22455.T46aa5f775286b--> | ||
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{| | {| border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;" id="T46aa5f775286b" class=" tableEdit GO_table_product dataTable" | ||
|- {{table_heading_style}} | |- {{table_heading_style}} | ||
!|Qualifier!!GO ID!!GO term name!!Reference | !|Qualifier!!GO ID!!GO term name!!Reference!!Evidence Code!!with/from!!Aspect!!Notes!!Status | ||
|- | |- | ||
| | | | ||
| | | | ||
GO:0005886 | |||
| | | | ||
plasma membrane | |||
| | | | ||
GO_REF: | GOA:hamap<br />GO_REF:0000020 | ||
| | | | ||
IEA: Inferred from Electronic Annotation | IEA: Inferred from Electronic Annotation | ||
| | | | ||
HAMAP:MF_00190 | |||
| | | | ||
C | |||
| | | | ||
Seeded from EcoCyc | Seeded from [[EcoCyc]] (v14.0) | ||
| | | | ||
complete | complete | ||
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| | | | ||
GO:0005886 | |||
| | | | ||
plasma membrane | |||
| | | | ||
GO_REF: | GOA:spkw<br />SP_KW:GO_REF:0000004 | ||
| | | | ||
IEA: Inferred from Electronic Annotation | IEA: Inferred from Electronic Annotation | ||
| | | | ||
SP_KW:KW-0997 | |||
| | | | ||
C | |||
| | | | ||
Seeded from EcoCyc | Seeded from [[EcoCyc]] (v14.0) | ||
| | | | ||
complete | complete | ||
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| | | | ||
GO:0005886 | |||
| | | | ||
plasma membrane | |||
| | | | ||
GO_REF: | GOA:spkw<br />SP_KW:GO_REF:0000004 | ||
| | | | ||
IEA: Inferred from Electronic Annotation | IEA: Inferred from Electronic Annotation | ||
| | | | ||
SP_KW:KW-1003 | |||
| | | | ||
C | |||
| | | | ||
Seeded from EcoCyc | Seeded from [[EcoCyc]] (v14.0) | ||
| | | | ||
complete | complete | ||
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| | | | ||
GO:0008152 | |||
| | | | ||
metabolic process | |||
| | | | ||
GO_REF: | GOA:interpro<br />GO_REF:0000002 | ||
| | | | ||
IEA: Inferred from Electronic Annotation | IEA: Inferred from Electronic Annotation | ||
| | | | ||
InterPro:IPR001736 | |||
| | | | ||
P | P | ||
| | | | ||
Seeded from EcoCyc | Seeded from [[EcoCyc]] (v14.0) | ||
| | | | ||
complete | complete | ||
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| | | | ||
GO:0008654 | |||
| | | | ||
phospholipid biosynthetic process | |||
| | | | ||
GO_REF: | GOA:hamap<br />GO_REF:0000020 | ||
| | | | ||
IEA: Inferred from Electronic Annotation | IEA: Inferred from Electronic Annotation | ||
| | | | ||
HAMAP:MF_00190 | |||
| | | | ||
P | |||
| | | | ||
Seeded from EcoCyc | Seeded from [[EcoCyc]] (v14.0) | ||
| | | | ||
complete | complete | ||
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| | | | ||
GO:0008654 | |||
| | | | ||
phospholipid biosynthetic process | |||
| | | | ||
GO_REF:0000004 | GOA:spkw<br />SP_KW:GO_REF:0000004 | ||
| | | | ||
IEA: Inferred from Electronic Annotation | IEA: Inferred from Electronic Annotation | ||
| | | | ||
SP_KW:KW- | SP_KW:KW-0594 | ||
| | | | ||
P | |||
| | | | ||
Seeded from EcoCyc | Seeded from [[EcoCyc]] (v14.0) | ||
| | | | ||
complete | complete | ||
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| | | | ||
GO:0016020 | |||
| | | | ||
membrane | |||
| | | | ||
GO_REF:0000004 | GOA:spkw<br />SP_KW:GO_REF:0000004 | ||
| | | | ||
IEA: Inferred from Electronic Annotation | IEA: Inferred from Electronic Annotation | ||
| | | | ||
SP_KW:KW- | SP_KW:KW-0472 | ||
| | | | ||
C | C | ||
| | | | ||
Seeded from EcoCyc | Seeded from [[EcoCyc]] (v14.0) | ||
| | | | ||
complete | complete | ||
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| | | | ||
GO:0016021 | |||
| | | | ||
integral to membrane | |||
| | | | ||
GO_REF:0000004 | GOA:spkw<br />SP_KW:GO_REF:0000004 | ||
| | | | ||
IEA: Inferred from Electronic Annotation | IEA: Inferred from Electronic Annotation | ||
| | | | ||
SP_KW:KW- | SP_KW:KW-0812 | ||
| | | | ||
C | |||
| | | | ||
Seeded from EcoCyc | Seeded from [[EcoCyc]] (v14.0) | ||
| | | | ||
complete | complete | ||
|- | |- | ||
| | | | ||
| | | | ||
GO:0016021 | |||
| | | | ||
integral to membrane | |||
| | | | ||
GO_REF:0000023 | |||
| | | | ||
IEA: Inferred from Electronic Annotation | |||
| | | | ||
SP_SL:SL-9909 | |||
| | | | ||
C | |||
| | | | ||
Seeded from EcoCyc | Seeded from [[EcoCyc]] (v14.0) | ||
| | | | ||
complete | |||
|- | |- | ||
| | | | ||
| | | | ||
GO:0008808 | |||
| | | | ||
cardiolipin synthase activity | |||
| | | | ||
PMID:353047 | |||
| | | | ||
IMP: Inferred from Mutant Phenotype | |||
| | | | ||
| | | | ||
F | F | ||
| | | | ||
| | | | ||
complete | complete | ||
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{| | {| border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;" id="O46aa5f85a6725" class=" tableEdit Product_interactions_table dataTable" | ||
|- {{table heading style}} | |- {{table heading style}} | ||
!Partner Type!!Partner!!Notes | !|Partner Type!!Partner!!Notes!!References!!Evidence | ||
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===Notes=== | ===Notes=== | ||
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{| | {| border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;" id="D46aa5f865b450" class=" tableEdit Product_localization_table" | ||
|- {{table heading style}} | |- {{table heading style}} | ||
!Compartment!!Description!!Evidence!!Notes | !|Compartment!!Description!!Evidence!!Reference/Source!!Notes | ||
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plasma membrane | plasma membrane | ||
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From EcoCyc<ref name='LIB:EcoCyc11.1'/> | From EcoCyc<ref name='LIB:EcoCyc11.1'/> | ||
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{|{{ | {| id="C46aa5f87c8cd1" class=" tableEdit Product_phys_prop_table" | ||
|- | |||
!align=left {{table heading style}} |Name | |||
|| | |||
|- | |- | ||
!{{table heading style}} |Sequence | !align=left {{table heading style}} |Sequence | ||
| | || | ||
[http://biocyc.org/ECOLI/sequence-aa?object=CARDIOLIPSYN-MONOMER at EcoCyc] | [http://biocyc.org/ECOLI/sequence-aa?object=CARDIOLIPSYN-MONOMER at EcoCyc] | ||
<pre>MTTVYTLVSW LAILGYWLLI AGVTLRILMK RRAVPSAMAW LLIIYILPLV GIIAYLAVGE | <pre>MTTVYTLVSW LAILGYWLLI AGVTLRILMK RRAVPSAMAW LLIIYILPLV GIIAYLAVGE | ||
| Line 348: | Line 358: | ||
FFSPLL</pre> | FFSPLL</pre> | ||
|- | |- | ||
!{{table heading style}} | | !align=left {{table heading style}} |Length | ||
| | || | ||
486 | |||
|- | |- | ||
!{{table heading style}} | | !align=left {{table heading style}} |Mol. Wt | ||
| | || | ||
54.824 kDa | |||
|- | |- | ||
!{{table heading style}} | | !align=left {{table heading style}} |pI | ||
| | || | ||
8.4 (calculated) | |||
|- | |- | ||
| | !align=left {{table heading style}} |Extinction coefficient | ||
|| | |||
93,850 - 94,475 (calc based on 15 Y, 13 W, and 5 C residues) | |||
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<big>'''Domains/Motifs/Modification Sites'''</big> | |||
<span id="Domains/Motifs/Modification Sites"><big>'''Domains/Motifs/Modification Sites'''</big></span> | |||
<table> | <table> | ||
<tr align="left" valign="top"> | <tr align="left" valign="top"> | ||
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{| | {| border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;" id="A46aa5f88317e6" class=" tableEdit Product_motif_table dataTable" | ||
|- {{table heading style}} | |- {{table heading style}} | ||
!|Type!!Residues!!Description!!Notes | !|Type!!Residues!!Description!!Notes!!References | ||
|- | |- | ||
| | | | ||
Domain | Domain | ||
| | | | ||
219..246 | |||
| | | | ||
[http://pfam.janelia.org/family/PF00614 PF00614 Phospholipase D Active site motif] | |||
| | |||
| | | | ||
PMID:19920124 | |||
|- | |- | ||
| | | | ||
Domain | Domain | ||
| | | | ||
399..426 | |||
| | |||
[http://pfam.janelia.org/family/PF00614 PF00614 Phospholipase D Active site motif] | |||
| | | | ||
| | | | ||
PMID:19920124 | |||
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</td> | </td> | ||
<td> | <td> | ||
<!-- motifs column 2--> | |||
<motif_map/> | |||
{{TMHMM Picture|cls}} | {{TMHMM Picture|cls}} | ||
</td> | </td> | ||
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<span id= | <table><tr valign='top'><td> | ||
<span id='Structure'></span><big>'''Structure'''</big><br /> | |||
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!align=left {{table heading style}} |Structures | !align=left {{table heading style}} |Structures | ||
|| | || | ||
<beststructure>cls | <beststructure> | ||
562</beststructure> | gene=cls | ||
taxon=562,83333 | |||
</beststructure> | |||
|- | |- | ||
!align=left {{table heading style}} |Models | !align=left {{table heading style}} |Models | ||
|| | || | ||
View models at: | View models at: | ||
* [http:// | * [http://www.proteinmodelportal.org/query/uniprot/P0A6H8 Protein Model Portal] | ||
* [http://bioinf.cs.ucl.ac.uk/genome3d/read?uniprot_id=P0A6H8 PSI-PRED (P0A6H8)] | |||
* [http://bioinf.cs.ucl.ac.uk/ | * [http://spock.genes.nig.ac.jp/~genome/cgi-bin/gkeytext.pl.cgi?A&QUERY1=P0A6H8 Genomes TO Protein (P0A6H8)] (GTOP) | ||
* [http://spock.genes.nig.ac.jp/~genome/ | |||
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==== Structure figures ==== | |||
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===Notes=== | ===Notes=== | ||
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!Resource type!!Source!!Notes/Reference | !|Resource type!!Source!!Notes/Reference | ||
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===Notes=== | ===Notes=== | ||
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{| | {| border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;" id="J46aa5f89259c0" class=" tableEdit Gene_accessions_table" | ||
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!Database!!Accession!!Notes | !|Database!!Accession!!Notes | ||
|- | |- | ||
| | |||
[http://www.ncbi.nlm.nih.gov/protein NCBI (Protein)] ([[NCBI (Protein)|EcoliWiki Page]]) | |||
| | |||
[http://www.ncbi.nlm.nih.gov/protein/16129210 GI:16129210] | |||
| | |||
Escherichia coli str. K-12 substr. MG1655 | |||
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[http:// | [http://www.ncbi.nlm.nih.gov/protein NCBI (Protein)] ([[NCBI (Protein)|EcoliWiki Page]]) | ||
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[http:// | [http://www.ncbi.nlm.nih.gov/protein/NP_415765.1 GeneID:945821] | ||
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Escherichia coli str. K-12 substr. MG1655 | |||
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[http://uniprot.org/ UniProt] ([[UniProt|EcoliWiki Page]]) | [http://www.pir.uniprot.org/ UniProt] ([[UniProt|EcoliWiki Page]]) | ||
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[ | [http://www.uniprot.org/uniprot/P0A6H8 UniProtKB/Swiss-Prot:P0A6H8] | ||
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Escherichia coli str. K-12 substr. MG1655 | |||
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[http:// | [http://www.ncbi.nlm.nih.gov/gene NCBI (Gene)] ([[NCBI (Gene)|EcoliWiki Page]]) | ||
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[http:// | [http://www.ncbi.nlm.nih.gov/gene?term=945821 GeneID:945821] | ||
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Escherichia coli str. K-12 substr. MG1655 | |||
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[[RegulonDB]] | |||
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RegulonDB: | |||
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''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]] | |||
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[[EchoBASE]] | |||
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EchoBASE: | |||
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''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]] | |||
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[[Category:Proteins]] | [[Category:Proteins]] | ||
Latest revision as of 20:36, 17 February 2015
{{#css:Suppresslinks.css}}<css>h1 .editsection { display:none;} h2 .editsection { display:none;}</css>
| Quickview | Gene | Gene Product(s) | Expression | Evolution | On One Page |
| Nomenclature | Function | Interactions | Localization | Sequence | Domains | Structure | Resources | Accessions | Links | References | Suggestions |
Nomenclature
See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.
| Standard name |
Cls |
|---|---|
| Synonyms |
cardiolipin synthase 1[1], B1249[2][1], YciJ[2][1], Nov[2][1], Cls[2][1] , ECK1243, JW1241, nov, yciJ, b1249 |
| Product description |
Cardiolipin synthase; mutants dihydroxybutylphosphonate resistant; novobiocin sensitivity[3] |
| EC number (for enzymes) |
2.7.8.-[1] |
| edit table |
Notes
Function
Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0005886 |
plasma membrane |
GOA:hamap |
IEA: Inferred from Electronic Annotation |
C |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0005886 |
plasma membrane |
GOA:spkw |
IEA: Inferred from Electronic Annotation |
C |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0005886 |
plasma membrane |
GOA:spkw |
IEA: Inferred from Electronic Annotation |
C |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0008152 |
metabolic process |
GOA:interpro |
IEA: Inferred from Electronic Annotation |
P |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0008654 |
phospholipid biosynthetic process |
GOA:hamap |
IEA: Inferred from Electronic Annotation |
P |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0008654 |
phospholipid biosynthetic process |
GOA:spkw |
IEA: Inferred from Electronic Annotation |
P |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0016020 |
membrane |
GOA:spkw |
IEA: Inferred from Electronic Annotation |
C |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0016021 |
integral to membrane |
GOA:spkw |
IEA: Inferred from Electronic Annotation |
C |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0016021 |
integral to membrane |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-9909 |
C |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0008808 |
cardiolipin synthase activity |
IMP: Inferred from Mutant Phenotype |
F |
complete | ||||
| edit table |
Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.
| Partner Type | Partner | Notes | References | Evidence |
|---|---|---|---|---|
| edit table |
Notes
Required for synthesis of cardiolipin.
Localization
See Help:Product_localization for how to add or edit information in this section of EcoliWiki.
| Compartment | Description | Evidence | Reference/Source | Notes |
|---|---|---|---|---|
|
plasma membrane |
From EcoCyc[5] |
| ||
| edit table |
Notes
Structure and Physical Properties
Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.
| Name | |
|---|---|
| Sequence |
MTTVYTLVSW LAILGYWLLI AGVTLRILMK RRAVPSAMAW LLIIYILPLV GIIAYLAVGE LHLGKRRAER ARAMWPSTAK WLNDLKACKH IFAEENSSVA APLFKLCERR QGIAGVKGNQ LQLMTESDDV MQALIRDIQL ARHNIEMVFY IWQPGGMADQ VAESLMAAAR RGIHCRLMLD SAGSVAFFRS PWPELMRNAG IEVVEALKVN LMRVFLRRMD LRQHRKMIMI DNYIAYTGSM NMVDPRYFKQ DAGVGQWIDL MARMEGPIAT AMGIIYSCDW EIETGKRILP PPPDVNIMPF EQASGHTIHT IASGPGFPED LIHQALLTAA YSAREYLIMT TPYFVPSDDL LHAICTAAQR GVDVSIILPR KNDSMLVGWA SRAFFTELLA AGVKIYQFEG GLLHTKSVLV DGELSLVGTV NLDMRSLWLN FEITLAIDDK GFGADLAAVQ DDYISRSRLL DARLWLKRPL WQRVAERLFY FFSPLL |
| Length |
486 |
| Mol. Wt |
54.824 kDa |
| pI |
8.4 (calculated) |
| Extinction coefficient |
93,850 - 94,475 (calc based on 15 Y, 13 W, and 5 C residues) |
| edit table |
Domains/Motifs/Modification Sites
|
See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.
|
<motif_map/> |
|
Structure
|
Structure figures
Notes
Gene Product Resources
See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.
| Resource type | Source | Notes/Reference |
|---|---|---|
| edit table |
Notes
Accessions in Other Databases
See Help:Gene_accessions for help with entering information into the Gene Accessions table.
| Database | Accession | Notes |
|---|---|---|
|
Escherichia coli str. K-12 substr. MG1655 | ||
|
Escherichia coli str. K-12 substr. MG1655 | ||
|
Escherichia coli str. K-12 substr. MG1655 | ||
|
Escherichia coli str. K-12 substr. MG1655 | ||
|
RegulonDB: |
Escherichia coli str. K-12 substr. MG1655 | |
|
EchoBASE: |
Escherichia coli str. K-12 substr. MG1655 | |
| edit table |
Notes
Links
| Name | URL | Comments |
|---|---|---|
| edit table |
References
See Help:References for how to manage references in EcoliWiki.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
- ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
- ↑ Pluschke, G et al. (1978) Function of phospholipids in Escherichia coli. Characterization of a mutant deficient in cardiolipin synthesis. J. Biol. Chem. 253 5048-55 PubMed
- ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ 6.0 6.1 Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed
Categories
