mhpA:Gene Product(s): Difference between revisions
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|{{Sub}}[[#Localization |Localization]] | |{{Sub}}[[#Localization |Localization]] | ||
|{{Sub}}[[#Sequence|Sequence]] | |{{Sub}}[[#Sequence|Sequence]] | ||
|{{Sub}}[[#Domains/Motifs/Modification Sites|Domains]] | |||
|{{Sub}}[[#Structure|Structure]] | |{{Sub}}[[#Structure|Structure]] | ||
|{{Sub}}[[#Gene Product Resources|Resources]] | |{{Sub}}[[#Gene Product Resources|Resources]] | ||
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!{{table heading style}} |Standard name | !align=left {{table heading style}} |Standard name | ||
| | || | ||
MhpA | MhpA | ||
|- | |- | ||
!{{table heading style}} |Synonyms | !align=left {{table heading style}} |Synonyms | ||
| | || | ||
3-(3-hydroxyphenyl)propionate hydroxylase | ''3-(3-hydroxyphenyl)propionate hydroxylase<ref name='LIB:Riley_2006'/>, B0347<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, MhpA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/> , ECK0344, JW0338, b0347'' | ||
|- | |- | ||
!{{table heading style}} |Product description | !align=left {{table heading style}} |Product description | ||
| | || | ||
|- | |- | ||
!{{table heading style}} |EC number (for enzymes) | !align=left {{table heading style}} |EC number (for enzymes) | ||
| | || | ||
* [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.- 1.14.13.-]<ref name='LIB:Riley_2006'/> | |||
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<protect><!--Nomenclature_notes--></protect> | <protect><!--Nomenclature_notes--></protect> | ||
===Notes=== | ===Notes=== | ||
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{{BacktoTop}} | {{BacktoTop}} | ||
<protect> | <protect> | ||
<big>'''Gene Ontology'''</big><br /> | <big>'''Gene Ontology'''</big><br /><!--box uid=421aa90e079fa326b6494f812ad13e79.20306.W46aa2a4bb54d3--> | ||
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{| | {| border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;" id="W46aa2a4bb54d3" class=" tableEdit GO_table_product dataTable" | ||
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!|Qualifier!!GO ID!!GO term name!!Reference | !|Qualifier!!GO ID!!GO term name!!Reference!!Evidence Code!!with/from!!Aspect!!Notes!!Status | ||
|- | |||
| | |||
| | |||
GO:0005737 | |||
| | |||
cytoplasm | |||
| | |||
| | |||
| | |||
| | |||
C | |||
| | |||
Seeded from Riley et al 2006 <ref name='LIB:Riley_2006'/>. | |||
| | |||
Missing: evidence, reference | |||
|- | |- | ||
| | | | ||
| | | | ||
GO:0004497 | |||
| | | | ||
monooxygenase activity | monooxygenase activity | ||
| | | | ||
GO_REF:0000002 | GOA:interpro<br />GO_REF:0000002 | ||
| | | | ||
IEA: Inferred from Electronic Annotation | IEA: Inferred from Electronic Annotation | ||
| Line 90: | Line 111: | ||
F | F | ||
| | | | ||
Seeded from EcoCyc | Seeded from [[EcoCyc]] (v14.0) | ||
| | | | ||
complete | complete | ||
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| | | | ||
GO:0008152 | |||
| | | | ||
metabolic process | |||
| | | | ||
GO_REF:0000002 | GOA:interpro<br />GO_REF:0000002 | ||
| | | | ||
IEA: Inferred from Electronic Annotation | IEA: Inferred from Electronic Annotation | ||
| | | | ||
InterPro: | InterPro:IPR003042 | ||
| | | | ||
P | P | ||
| | | | ||
Seeded from EcoCyc | Seeded from [[EcoCyc]] (v14.0) | ||
| | | | ||
complete | complete | ||
| Line 116: | Line 137: | ||
| | | | ||
GO:0008688 | |||
| | | | ||
3-(3-hydroxy-phenyl)propionate hydroxylase activity | |||
| | | | ||
GO_REF: | GOA:hamap<br />GO_REF:0000020 | ||
| | | | ||
IEA: Inferred from Electronic Annotation | IEA: Inferred from Electronic Annotation | ||
| | | | ||
HAMAP:MF_01652 | |||
| | | | ||
F | F | ||
| | | | ||
Seeded from EcoCyc | Seeded from [[EcoCyc]] (v14.0) | ||
| | | | ||
complete | complete | ||
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| | | | ||
GO:0016491 | |||
| | | | ||
oxidoreductase activity | oxidoreductase activity | ||
| | | | ||
GO_REF:0000002 | GOA:interpro<br />GO_REF:0000002 | ||
| | | | ||
IEA: Inferred from Electronic Annotation | IEA: Inferred from Electronic Annotation | ||
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F | F | ||
| | | | ||
Seeded from EcoCyc | Seeded from [[EcoCyc]] (v14.0) | ||
| | | | ||
complete | complete | ||
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| | | | ||
GO:0016491 | |||
| | | | ||
oxidoreductase activity | oxidoreductase activity | ||
| | | | ||
GO_REF:0000004 | GOA:spkw<br />SP_KW:GO_REF:0000004 | ||
| | | | ||
IEA: Inferred from Electronic Annotation | IEA: Inferred from Electronic Annotation | ||
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F | F | ||
| | | | ||
Seeded from EcoCyc | Seeded from [[EcoCyc]] (v14.0) | ||
| | | | ||
complete | complete | ||
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| | | | ||
GO:0016709 | |||
| | |||
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen | |||
| | |||
GOA:spec<br />GO_REF:0000003 | |||
| | |||
IEA: Inferred from Electronic Annotation | |||
| | |||
EC:1.14.13 | |||
| | |||
F | |||
| | |||
Seeded from [[EcoCyc]] (v14.0) | |||
| | |||
complete | |||
|- | |||
| | |||
| | |||
GO:0019439 | |||
| | | | ||
aromatic compound catabolic process | aromatic compound catabolic process | ||
| | | | ||
GO_REF:0000004 | GOA:spkw<br />SP_KW:GO_REF:0000004 | ||
| | | | ||
IEA: Inferred from Electronic Annotation | IEA: Inferred from Electronic Annotation | ||
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P | P | ||
| | | | ||
Seeded from EcoCyc | Seeded from [[EcoCyc]] (v14.0) | ||
| | | | ||
complete | complete | ||
|- | |- | ||
| | | | ||
| | | | ||
GO:0019622 | |||
| | | | ||
3-(3-hydroxy)phenylpropionate catabolic process | |||
| | | | ||
GOA:hamap<br />GO_REF:0000020 | |||
| | | | ||
IEA: Inferred from Electronic Annotation | |||
| | | | ||
HAMAP:MF_01652 | |||
| | | | ||
P | |||
| | | | ||
Seeded from | Seeded from [[EcoCyc]] (v14.0) | ||
| | | | ||
complete | |||
|- | |- | ||
| | | | ||
| | | | ||
GO:0055114 | |||
| | | | ||
oxidation reduction | |||
| | | | ||
GOA:interpro<br />GO_REF:0000002 | |||
| | | | ||
IEA: Inferred from Electronic Annotation | |||
| | | | ||
InterPro:IPR002938 | |||
| | | | ||
P | P | ||
| | | | ||
Seeded from EcoCyc | Seeded from [[EcoCyc]] (v14.0) | ||
| | | | ||
complete | |||
|- | |- | ||
| | | | ||
| | | | ||
GO:0055114 | |||
| | | | ||
oxidation reduction | |||
| | | | ||
GO_REF: | GOA:spkw<br />SP_KW:GO_REF:0000004 | ||
| | | | ||
IEA: Inferred from Electronic Annotation | IEA: Inferred from Electronic Annotation | ||
| | | | ||
SP_KW:KW-0560 | |||
| | | | ||
P | |||
| | | | ||
Seeded from EcoCyc | Seeded from [[EcoCyc]] (v14.0) | ||
| | | | ||
complete | complete | ||
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{| | {| border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;" id="O46aa2a52b49bc" class=" tableEdit Product_interactions_table dataTable" | ||
|- {{table heading style}} | |- {{table heading style}} | ||
!Partner Type!!Partner!!Notes | !|Partner Type!!Partner!!Notes!!References!!Evidence | ||
|-class= | |- | ||
|[{{SERVER}}{{SCRIPTPATH}} | | | ||
Protein | |||
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glpD<br /> | |||
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PMID:16606699 | |||
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Experiment(s):EBI-1136317<br /> | |||
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Protein | |||
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rsuA<br /> | |||
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PMID:16606699 | |||
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Experiment(s):EBI-1136317<br /> | |||
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<!--Function_notes--></protect> | <!--Function_notes--></protect> | ||
===Notes=== | ===Notes=== | ||
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!Compartment!!Description!!Evidence!!Notes | !|Compartment!!Description!!Evidence!!Reference/Source!!Notes | ||
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{|{{ | {| id="H46aa2a54726e3" class=" tableEdit Product_phys_prop_table" | ||
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!align=left {{table heading style}} |Name | |||
|| | |||
|- | |- | ||
!{{table heading style}} |Sequence | !align=left {{table heading style}} |Sequence | ||
| | || | ||
[http://biocyc.org/ECOLI/sequence-aa?object=MHPHYDROXY-MONOMER at EcoCyc] | [http://biocyc.org/ECOLI/sequence-aa?object=MHPHYDROXY-MONOMER at EcoCyc] | ||
<pre>MAIQHPDIQP AVNHSVQVAI AGAGPVGLMM ANYLGQMGID VLVVEKLDKL IDYPRAIGID | <pre>MAIQHPDIQP AVNHSVQVAI AGAGPVGLMM ANYLGQMGID VLVVEKLDKL IDYPRAIGID | ||
| Line 319: | Line 388: | ||
LTRPDADVSV EKVA</pre> | LTRPDADVSV EKVA</pre> | ||
|- | |- | ||
!{{table heading style}} | | !align=left {{table heading style}} |Length | ||
| | || | ||
554 | |||
|- | |- | ||
!{{table heading style}} | | !align=left {{table heading style}} |Mol. Wt | ||
| | || | ||
62.184 kDa | |||
|- | |- | ||
!{{table heading style}} | | !align=left {{table heading style}} |pI | ||
| | || | ||
7.9 (calculated) | |||
|- | |- | ||
| | !align=left {{table heading style}} |Extinction coefficient | ||
|| | |||
82,390 - 83,140 (calc based on 11 Y, 12 W, and 6 C residues) | |||
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= | |||
<!--box uid=421aa90e079fa326b6494f812ad13e79.20306.G46aa2a54cb640--> | <span id="Domains/Motifs/Modification Sites"><big>'''Domains/Motifs/Modification Sites'''</big></span><table> | ||
<tr align="left" valign="top"> | |||
<td><!--box uid=421aa90e079fa326b6494f812ad13e79.20306.G46aa2a54cb640--> | |||
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|- {{table heading style}} | |- {{table heading style}} | ||
!Type!!Residues!!Description!!Notes | !|Type!!Residues!!Description!!Notes!!References | ||
|-class= | |- | ||
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Domain | |||
| | |||
15..353 | |||
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[http://pfam.janelia.org/family/PF01494 PF01494 FAD binding domain] | |||
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PMID:19920124 | |||
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<td> | |||
<!-- motifs column 2--> | |||
<motif_map/> | |||
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<span id= | <table><tr valign='top'><td> | ||
<span id='Structure'></span><big>'''Structure'''</big><br /> | |||
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!align=left {{table heading style}} |Structures | !align=left {{table heading style}} |Structures | ||
|| | || | ||
<beststructure>mhpA | <beststructure> | ||
562</beststructure> | gene=mhpA | ||
taxon=562,83333 | |||
</beststructure> | |||
|- | |- | ||
!align=left {{table heading style}} |Models | !align=left {{table heading style}} |Models | ||
|| | || | ||
View models at: | View models at: | ||
* [http:// | * [http://www.proteinmodelportal.org/query/uniprot/P77397 Protein Model Portal] | ||
* [http://bioinf.cs.ucl.ac.uk/genome3d/read?uniprot_id=P77397 PSI-PRED (P77397)] | |||
* [http://bioinf.cs.ucl.ac.uk/ | * [http://spock.genes.nig.ac.jp/~genome/cgi-bin/gkeytext.pl.cgi?A&QUERY1=P77397 Genomes TO Protein (P77397)] (GTOP) | ||
* [http://spock.genes.nig.ac.jp/~genome/ | |||
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<!--Structure_notes--></protect> | </td><td></protect> | ||
==== Structure figures ==== | |||
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===Notes=== | ===Notes=== | ||
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!Resource type!!Source!!Notes/Reference | !|Resource type!!Source!!Notes/Reference | ||
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===Notes=== | ===Notes=== | ||
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{| | {| border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;" id="O46aa2a55b538a" class=" tableEdit Gene_accessions_table" | ||
|- {{table_heading_style}} | |- {{table_heading_style}} | ||
!Database!!Accession!!Notes | !|Database!!Accession!!Notes | ||
|- | |- | ||
| | |||
[http://www.ncbi.nlm.nih.gov/protein NCBI (Protein)] ([[NCBI (Protein)|EcoliWiki Page]]) | |||
| | |||
[http://www.ncbi.nlm.nih.gov/protein/16128332 GI:16128332] | |||
| | |||
Escherichia coli str. K-12 substr. MG1655 | |||
|- | |||
| | |||
[http://www.ncbi.nlm.nih.gov/protein NCBI (Protein)] ([[NCBI (Protein)|EcoliWiki Page]]) | |||
| | |||
[http://www.ncbi.nlm.nih.gov/protein/NP_414881.1 GeneID:945197] | |||
| | |||
Escherichia coli str. K-12 substr. MG1655 | |||
|- | |||
| | |||
[[ASAP]] | |||
| | |||
ASAP:ABE-0001196 | |||
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''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]] | |||
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[http://www.pir.uniprot.org/ UniProt] ([[UniProt|EcoliWiki Page]]) | |||
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[http://www.uniprot.org/uniprot/P77397 UniProtKB/Swiss-Prot:P77397] | |||
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Escherichia coli str. K-12 substr. MG1655 | |||
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[[EcoCyc]] | |||
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EcoCyc:M010 | |||
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''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]] | |||
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[[EcoGene]] | |||
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EcoGene:EG20273 | |||
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''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]] | |||
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[http:// | [http://www.ncbi.nlm.nih.gov/gene NCBI (Gene)] ([[NCBI (Gene)|EcoliWiki Page]]) | ||
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[http:// | [http://www.ncbi.nlm.nih.gov/gene?term=945197 GeneID:945197] | ||
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Escherichia coli str. K-12 substr. MG1655 | |||
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[[RegulonDB]] | |||
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RegulonDB:ECK120004469 | |||
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''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]] | |||
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[[EchoBASE]] | |||
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EchoBASE:EB4166 | |||
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''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]] | |||
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===Notes=== | ===Notes=== | ||
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<references/> | <references /> | ||
__NOTOC__ | __NOTOC__ | ||
===Categories=== | ===Categories=== | ||
{{BacktoTop}} | {{BacktoTop}} | ||
[[Category:Proteins]] | [[Category:Proteins]] | ||
Latest revision as of 20:24, 17 February 2015
{{#css:Suppresslinks.css}}<css>h1 .editsection { display:none;} h2 .editsection { display:none;}</css>
| Quickview | Gene | Gene Product(s) | Expression | Evolution | On One Page |
| Nomenclature | Function | Interactions | Localization | Sequence | Domains | Structure | Resources | Accessions | Links | References | Suggestions |
Nomenclature
See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.
| Standard name |
MhpA |
|---|---|
| Synonyms |
3-(3-hydroxyphenyl)propionate hydroxylase[1], B0347[2][1], MhpA[2][1] , ECK0344, JW0338, b0347 |
| Product description | |
| EC number (for enzymes) | |
| edit table |
Notes
Function
Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0005737 |
cytoplasm |
C |
Seeded from Riley et al 2006 [1]. |
Missing: evidence, reference | ||||
| GO:0004497 |
monooxygenase activity |
GOA:interpro |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0008152 |
metabolic process |
GOA:interpro |
IEA: Inferred from Electronic Annotation |
P |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0008688 |
3-(3-hydroxy-phenyl)propionate hydroxylase activity |
GOA:hamap |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0016491 |
oxidoreductase activity |
GOA:interpro |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0016491 |
oxidoreductase activity |
GOA:spkw |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0016709 |
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen |
GOA:spec |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0019439 |
aromatic compound catabolic process |
GOA:spkw |
IEA: Inferred from Electronic Annotation |
P |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0019622 |
3-(3-hydroxy)phenylpropionate catabolic process |
GOA:hamap |
IEA: Inferred from Electronic Annotation |
P |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0055114 |
oxidation reduction |
GOA:interpro |
IEA: Inferred from Electronic Annotation |
P |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0055114 |
oxidation reduction |
GOA:spkw |
IEA: Inferred from Electronic Annotation |
P |
Seeded from EcoCyc (v14.0) |
complete | ||
| edit table |
Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.
| Partner Type | Partner | Notes | References | Evidence |
|---|---|---|---|---|
|
Protein |
glpD |
Experiment(s):EBI-1136317 | ||
|
Protein |
rsuA |
Experiment(s):EBI-1136317 | ||
| edit table |
Notes
Localization
See Help:Product_localization for how to add or edit information in this section of EcoliWiki.
| Compartment | Description | Evidence | Reference/Source | Notes |
|---|---|---|---|---|
| edit table |
Notes
Structure and Physical Properties
Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.
| Name | |
|---|---|
| Sequence |
MAIQHPDIQP AVNHSVQVAI AGAGPVGLMM ANYLGQMGID VLVVEKLDKL IDYPRAIGID DEALRTMQSV GLVDDVLPHT TPWHAMRFLT PKGRCFADIQ PMTDEFGWPR RNAFIQPQVD AVMLEGVSRF PNVRCLFSRE LEAFSQQDDE VTLHLKTAEG QREIVKAQWL VACDGGASFV RRTLNVPFEG KTAPNQWIVV DIANDPLSTP HIYLCCDPVR PYVSAALPHA VRRFEFMVMP GETEEQLREP QNMRKLLSKV LPNPDNVELI RQRVYTHNAR LAQRFRIDRV LLAGDAAHIM PVWQGQGYNS GMRDAFNLAW KLALVIQGKA RDALLDTYQQ ERRDHAKAMI DLSVTAGNVL APPKRWQGTL RDGVSWLLNY LPPVKRYFLE MRFKPMPQYY GGALMREGEA KHSPVGKMFI QPKVTLENGD VTLLDNAIGA NFAVIGWGCN PLWGMSDEQI QQWRALGTRF IQVVPEVQIH TAQDNHDGVL RVGDTQGRLR SWFAQHNASL VVMRPDRFVA ATAIPQTLGK TLNKLASVMT LTRPDADVSV EKVA |
| Length |
554 |
| Mol. Wt |
62.184 kDa |
| pI |
7.9 (calculated) |
| Extinction coefficient |
82,390 - 83,140 (calc based on 11 Y, 12 W, and 6 C residues) |
| edit table |
Domains/Motifs/Modification Sites
|
See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.
|
<motif_map/> |
|
Structure
|
Structure figures
Notes
Gene Product Resources
See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.
| Resource type | Source | Notes/Reference |
|---|---|---|
| edit table |
Notes
Accessions in Other Databases
See Help:Gene_accessions for help with entering information into the Gene Accessions table.
| Database | Accession | Notes |
|---|---|---|
|
Escherichia coli str. K-12 substr. MG1655 | ||
|
Escherichia coli str. K-12 substr. MG1655 | ||
|
Escherichia coli str. K-12 substr. MG1655 | ||
|
Escherichia coli str. K-12 substr. MG1655 | ||
|
Escherichia coli str. K-12 substr. MG1655 | ||
|
Escherichia coli str. K-12 substr. MG1655 | ||
|
Escherichia coli str. K-12 substr. MG1655 | ||
|
Escherichia coli str. K-12 substr. MG1655 | ||
|
Escherichia coli str. K-12 substr. MG1655 | ||
| edit table |
Notes
Links
| Name | URL | Comments |
|---|---|---|
| edit table |
References
See Help:References for how to manage references in EcoliWiki.
- ↑ 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
- ↑ 2.0 2.1 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ 3.0 3.1 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
- ↑ Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed
Categories
- GO:0005737 ! cytoplasm
- GO:0004497 ! monooxygenase activity
- GO:0008152 ! metabolic process
- GO:0008688 ! 3-(3-hydroxyphenyl)propionate hydroxylase activity
- GO:0016491 ! oxidoreductase activity
- GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
- GO:0019439 ! aromatic compound catabolic process
- GO:0019622 ! 3-(3-hydroxy)phenylpropionate catabolic process
- GO:0055114 ! oxidation-reduction process
- Proteins