mtn:Gene Product(s): Difference between revisions

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!align=left {{table heading style}} |Synonyms
!align=left {{table heading style}} |Synonyms
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5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase<ref name='LIB:Riley_2006'/>, B0159<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, Mtn<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, YadA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, Pfs<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>  
''5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase<ref name='LIB:Riley_2006'/>, B0159<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, Mtn<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, YadA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, Pfs<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/> , ECK0158, JW0155, mtnN, pfs, yadA, b0159''
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!align=left {{table heading style}} |Product description
!align=left {{table heading style}} |Product description
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!|Qualifier!!GO ID!!GO term name!!Reference(s)!!Evidence Code!!with/from!!Aspect!!Notes!!Status
!|Qualifier!!GO ID!!GO term name!!Reference!!Evidence Code!!with/from!!Aspect!!Notes!!Status
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!|Partner Type!!Partner!!Notes!!References!!Evidence
!|Partner Type!!Partner!!Notes!!References!!Evidence
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{| border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;"  id="H46a7b12545887"  class=" tableEdit Product_localization_table"   
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!|Compartment!!Description!!Evidence!!Source!!Notes
!|Compartment!!Description!!Evidence!!Reference/Source!!Notes


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!align=left {{table heading style}} |Name
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!align=left {{table heading style}} |Extinction coefficient
!align=left {{table heading style}} |Extinction coefficient
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5,960 - 6,585 (calc based on 4 Y, W, and 5 C residues)
5,960 - 6,585 (calc based on 4 Y, 0 W, and 5 C residues)
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5,960 - 6,585 (calc based on 4 Y, W, and 5 C residues)
5,960 - 6,585 (calc based on 4 Y, 0 W, and 5 C residues)


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!|Type!!Residues!!Description!!Notes!!References
!|Type!!Residues!!Description!!Notes!!References
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Domain
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2..227
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[http://pfam.janelia.org/family/PF01048 PF01048  Phosphorylase superfamily]
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PMID:19920124


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View models at:
View models at:
* [http://dragon.bio.purdue.edu/ecolpredict2/localsearch/cgi-bin/search3.cgi?q=recA EcoliPredict]
* [http://www.proteinmodelportal.org/query/uniprot/P0AF12 Protein Model Portal]
* [http://modbase.compbio.ucsf.edu/modbase-cgi/model_search.cgi?searchmode=default&displaymode=moddetail&searchproperties=ALL&searchvalue=recA&organism=562&organismtext= ModBase]
* [http://bioinf.cs.ucl.ac.uk/genome3d/read?uniprot_id=P0AF12 PSI-PRED (P0AF12)]
* [http://bioinf.cs.ucl.ac.uk/psipred/ PSI-PRED]
* [http://spock.genes.nig.ac.jp/~genome/cgi-bin/gkeytext.pl.cgi?A&QUERY1=P0AF12 Genomes TO Protein (P0AF12)] (GTOP)
* [http://www.ebi.ac.uk/msd-srv/pqs/ Protein Quaternary Structure] (PQS)
* [http://spock.genes.nig.ac.jp/~genome/search.html Genomes TO Protein] (GTOP)


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!|Resource type!!Source!!Notes/Reference
!|Resource type!!Source!!Notes/Reference
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!|Database!!Accession!!Notes
!|Database!!Accession!!Notes
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[http://ecocyc.org EcoCyc] ([[EcoCyc|EcoliWiki Page]])  
[http://www.ncbi.nlm.nih.gov/protein NCBI (Protein)] ([[NCBI (Protein)|EcoliWiki Page]])
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[http://www.ncbi.nlm.nih.gov/protein/16128152 GI:16128152]
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Escherichia coli str. K-12 substr. MG1655
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[http://www.ncbi.nlm.nih.gov/protein NCBI (Protein)] ([[NCBI (Protein)|EcoliWiki Page]])
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[http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=EG11090-MONOMER EcoCyc:EG11090-MONOMER]
[http://www.ncbi.nlm.nih.gov/protein/NP_414701.1 GeneID:948542]
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Escherichia coli str. K-12 substr. MG1655
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[[ASAP]]
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ASAP:ABE-0000545
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''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]]
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[http://www.pir.uniprot.org/ UniProt] ([[UniProt|EcoliWiki Page]])
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[http://www.uniprot.org/uniprot/P0AF12 UniProtKB/Swiss-Prot:P0AF12]
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Escherichia coli str. K-12 substr. MG1655
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[[EcoCyc]]
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EcoCyc:EG11090
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''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]]
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[http://swissmodel.expasy.org/repository/ SwissModel] ([[SwissModel|EcoliWiki Page]])
[[EcoGene]]
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[http://swissmodel.expasy.org/repository/smr.php?job=2&sptr_ac=P0AF12 SwissModel:P0AF12]
EcoGene:EG11090
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''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]]
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[http://uniprot.org/ UniProt] ([[UniProt|EcoliWiki Page]])  
[http://www.ncbi.nlm.nih.gov/gene NCBI (Gene)] ([[NCBI (Gene)|EcoliWiki Page]])
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[[uniprot:P0AF12|UniProt:P0AF12]]
[http://www.ncbi.nlm.nih.gov/gene?term=948542 GeneID:948542]
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Escherichia coli str. K-12 substr. MG1655
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[http://pfam.sanger.ac.uk/ PFAM] ([[PFAM|EcoliWiki Page]])
[[RegulonDB]]
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[http://pfam.sanger.ac.uk/family?acc=PF01048 PFAM:PF01048]
RegulonDB:ECK120001078
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''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]]
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[http://www.ncbi.nlm.nih.gov/RefSeq/ RefSeq] ([[RefSeq|EcoliWiki Page]])
[[EchoBASE]]
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[http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=NP_414701 RefSeq:NP_414701]
EchoBASE:EB1082
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''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]]


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!|Name!!URL!!Comments
!|Name!!URL!!Comments
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===Categories===
===Categories===
{{BacktoTop}}
{{BacktoTop}}
[[Category:GO:0005737_!_cytoplasm]][[Category:GO:0015949_!_nucleobase, nucleoside and nucleotide interconversion]][[Category:Complex:5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase]][[Category:Products with structures in PDB]]
[[Category:Proteins]]

Latest revision as of 20:21, 17 February 2015

{{#css:Suppresslinks.css}}<css>h1 .editsection { display:none;} h2 .editsection { display:none;}</css>

Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

Pfs

Synonyms

5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase[1], B0159[2][1], Mtn[2][1], YadA[2][1], Pfs[2][1] , ECK0158, JW0155, mtnN, pfs, yadA, b0159

Product description

5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase[2][3];

Component of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase[3]

5'-Methylthioadenosine nucleosidase; S-adenosylhomocysteine and 5'-deoxyadenosine are also substrates[4]

EC number (for enzymes) 
3.2.2.9[1]
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Notes

Function

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Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0008782

adenosylhomocysteine nucleosidase activity

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_01684

F

Seeded from EcoCyc (v14.0)

complete

GO:0008782

adenosylhomocysteine nucleosidase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR010049

F

Seeded from EcoCyc (v14.0)

complete

GO:0008782

adenosylhomocysteine nucleosidase activity

GOA:spec
GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:3.2.2.9

F

Seeded from EcoCyc (v14.0)

complete

GO:0008930

methylthioadenosine nucleosidase activity

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_01684

F

Seeded from EcoCyc (v14.0)

complete

GO:0008930

methylthioadenosine nucleosidase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR010049

F

Seeded from EcoCyc (v14.0)

complete

GO:0009164

nucleoside catabolic process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR010049

P

Seeded from EcoCyc (v14.0)

complete

GO:0019284

L-methionine biosynthetic process from S-adenosylmethionine

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_01684

P

Seeded from EcoCyc (v14.0)

complete

GO:0019509

L-methionine salvage from methylthioadenosine

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR010049

P

Seeded from EcoCyc (v14.0)

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

Subunits of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase

could be indirect

Protein

Subunits of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase

could be indirect


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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes
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Notes

Structure and Physical Properties

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Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MKIGIIGAME EEVTLLRDKI ENRQTISLGG CEIYTGQLNG TEVALLKSGI GKVAAALGAT
LLLEHCKPDV IINTGSAGGL APTLKVGDIV VSDEARYHDA DVTAFGYEYG QLPGCPAGFK
ADDKLIAAAE ACIAELNLNA VRGLIVSGDA FINGSVGLAK IRHNFPQAIA VEMEATAIAH
VCHNFNVPFV VVRAISDVAD QQSHLSFDEF LAVAAKQSSL MVESLVQKLA HG

at EcoCyc 

MKIGIIGAME EEVTLLRDKI ENRQTISLGG CEIYTGQLNG TEVALLKSGI GKVAAALGAT
LLLEHCKPDV IINTGSAGGL APTLKVGDIV VSDEARYHDA DVTAFGYEYG QLPGCPAGFK
ADDKLIAAAE ACIAELNLNA VRGLIVSGDA FINGSVGLAK IRHNFPQAIA VEMEATAIAH
VCHNFNVPFV VVRAISDVAD QQSHLSFDEF LAVAAKQSSL MVESLVQKLA HG
Length

232

232

Mol. Wt

24.353 kDa

24.353 kDa

pI

4.9 (calculated)

4.9 (calculated)

Extinction coefficient

5,960 - 6,585 (calc based on 4 Y, 0 W, and 5 C residues)

5,960 - 6,585 (calc based on 4 Y, 0 W, and 5 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Domain

2..227

PF01048 Phosphorylase superfamily

PMID:19920124[5]

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<motif_map/>

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=mtn taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16128152

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:948542

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0000545

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P0AF12

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG11090

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG11090

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:948542

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120001078

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB1082

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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